PMID- 33526272
OWN - NLM
STAT- MEDLINE
DCOM- 20211111
LR  - 20211204
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 82
IP  - 4
DP  - 2021 Apr
TI  - Diversities of HLA-A, -B, -C, -DRB1 and -DQB1 loci in Chinese Kazak population 
      and its genetic relatedness dissection with multiple populations: a comparative 
      study.
PG  - 215-225
LID - S0198-8859(20)30341-4 [pii]
LID - 10.1016/j.humimm.2020.06.006 [doi]
AB  - Studying the allele and haplotype distributions of human leukocyte antigen (HLA) 
      loci at 2nd-field level in different populations was important. Allele and 
      haplotype frequencies of HLA-A, -B, -C, -DRB1 and -DQB1 loci in 110 unrelated 
      healthy Kazak individuals living in Xinjiang (China) were analyzed using 
      polymerase chain reaction sequence based typing. Thirty HLA-A, 48 HLA-B, 24 
      HLA-C, 34 HLA-DRB1 and 18 HLA-DQB1 alleles were detected at the 2nd-field level 
      in the Kazak population. Frequencies of HLA alleles, genotypes, and haplotypes 
      were calculated, and some exhibited significantly different distributions among 
      different populations. A neighbor-joining (NJ) tree, heatmap, multidimensional 
      scaling (MDS) and principal component analysis (PCA) were used to explore the 
      genetic relationships between the Kazak population and 32 reference populations 
      distributed in Asia, Africa, America and Europe using frequency data of HLA-A, 
      -B, -C and -DRB1 loci. The NJ tree, heatmap, and MDS of the 33 populations were 
      constructed based on pairwise D(A) values of populations obtained by the HLA-A, 
      -B, -C and -DRB1 allele frequencies. Different PCA plots were constructed based 
      on the allele frequencies of HLA-A, -B, -C and -DRB1 or estimated haplotypic 
      frequencies of HLA-A, -B, -C loci. The data obtained in the present research can 
      be used for research on HLA-related diseases or paternity relationships, and aid 
      to finding the best matched donors in stem cell transplantation for Kazak 
      individuals.
CI  - Copyright (c) 2020. Published by Elsevier Inc.
FAU - Wang, Hong-Dan
AU  - Wang HD
AD  - Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, 
      College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, PR China; 
      Medical Genetics Institute of Henan Province, Henan Provincial People's Hospital, 
      Zhengzhou University People's Hospital, Zhengzhou 450003, PR China; National 
      Health Commission Key Laboratory of Birth Defects Prevention, Henan Key 
      Laboratory of Population Defects Prevention, Henan Institute of Reproduction 
      Health Science and Technology, Zhengzhou 450014, PR China.
FAU - Jin, Xiao-Ye
AU  - Jin XY
AD  - Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, 
      College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, PR China; 
      Clinical Research Center of Shaanxi Province for Dental and Maxillofacial 
      Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, PR 
      China; College of Forensic Science, Xi'an Jiaotong University Health Science 
      Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, PR China.
FAU - Yin, Shan-Shan
AU  - Yin SS
AD  - Henan Academy of Medical Sciences, Zhengzhou 450000, PR China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Medical Genetics Institute of Henan Province, Henan Provincial People's Hospital, 
      Zhengzhou University People's Hospital, Zhengzhou 450003, PR China.
FAU - Su, Jun-Xiang
AU  - Su JX
AD  - Medical Genetics Institute of Henan Province, Henan Provincial People's Hospital, 
      Zhengzhou University People's Hospital, Zhengzhou 450003, PR China.
FAU - Shen, Chun-Mei
AU  - Shen CM
AD  - Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi 
      Normal University, Xi'an 710062, PR China. Electronic address: 
      cmshen2004@126.com.
FAU - Zhu, Bo-Feng
AU  - Zhu BF
AD  - Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, 
      College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, PR China; 
      Clinical Research Center of Shaanxi Province for Dental and Maxillofacial 
      Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, PR 
      China. Electronic address: zhubofeng7372@126.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20210129
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - China
MH  - *Ethnicity
MH  - Gene Frequency
MH  - Genetic Variation
MH  - *Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Principal Component Analysis
MH  - Tissue Donors
MH  - Transplantation
OTO - NOTNLM
OT  - Allele frequency
OT  - Haplotype frequency
OT  - Human leukocyte antigen
OT  - Kazak population
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/02/03 06:00
MHDA- 2021/11/12 06:00
CRDT- 2021/02/02 05:49
PHST- 2019/11/04 00:00 [received]
PHST- 2020/06/12 00:00 [revised]
PHST- 2020/06/12 00:00 [accepted]
PHST- 2021/02/03 06:00 [pubmed]
PHST- 2021/11/12 06:00 [medline]
PHST- 2021/02/02 05:49 [entrez]
AID - S0198-8859(20)30341-4 [pii]
AID - 10.1016/j.humimm.2020.06.006 [doi]
PST - ppublish
SO  - Hum Immunol. 2021 Apr;82(4):215-225. doi: 10.1016/j.humimm.2020.06.006. Epub 2021 
      Jan 29.