PMID- 33527018
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210206
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 13
IP  - 1
DP  - 2021
TI  - Effects of high-intensity training on prostate cancer-induced cardiac atrophy.
PG  - 197-209
AB  - BACKGROUND: Recent evidence suggests prostate cancer independent of treatment has 
      atrophic effects on whole heart and left ventricular (LV) masses, associated with 
      reduced endurance exercise capacity. In a pre-clinical model, we tested the 
      hypothesis that high-intensity training could prevent cardiac atrophy with 
      prostate cancer and alter cardiac protein degradation mechanisms. METHODS: 
      Dunning R-3327 AT-1 prostate cancer cells (1x10(5)) were injected into the 
      ventral prostate lobe of 5-6 mo immunocompetent Copenhagen rats (n=24). These 
      animals were randomized into two groups, tumor-bearing exercise (TBEX, n=15) or 
      tumor bearing sedentary (TBS, n=9). Five days after surgery, TBEX animals began 
      exercise on a treadmill (25 m/min, 15 degrees  incline) for 45-60 min/day for 18+/-2 days. 
      Pre-surgery (Pre), and post-exercise training (Post) echocardiographic evaluation 
      (Vivid S6, GE Health Care), using the parasternal short axis view, was used to 
      examine ventricle dimensions. Markers of protein degradation (muscle atrophy 
      F-box, Cathepsin B, Cathepsin L) in the left ventricle were semi-quantified via 
      Western Blot. RESULTS: There were no significant differences in tumor mass 
      between groups (TBEX 3.4+/-0.7, TBS 2.8+/-0.6 g, P=0.3), or body mass (TBEX 317+/-5, 
      TBS 333+/-7 g, P=0.2). Heart-to-body mass ratio was lower in TBS group compared to 
      TBEX (2.3+/-0.1 vs. 2.5+/-0.1 mg/g, P<0.05). LV/body mass ratio was also lower in the 
      TBS group (1.6+/-0.1 vs. 1.8+/-0.1 mg/g, P<0.05). From Pre-Post, TBEX had significant 
      increases in SV (~20% P<0.05) whereas TBS had no significant change. There were 
      no significant differences between groups for markers of protein degradation. 
      CONCLUSION: This study suggests that high-intensity exercise can improve LV 
      function and increase LV mass concurrent with prostate cancer development, versus 
      sedentary counterparts. Given cardiac dysfunction often manifests with 
      conventional anti-cancer treatments, a short-term high-intensity training 
      program, prior to treatment, may improve cardiac function and fatigue resistance 
      in cancer patients.
CI  - AJTR Copyright (c) 2021.
FAU - Baumfalk, Dryden R
AU  - Baumfalk DR
AD  - Department of Kinesiology, Kansas State University Manhattan 66506, Kansas, USA.
FAU - Opoku-Acheampong, Alexander B
AU  - Opoku-Acheampong AB
AD  - Department of Kinesiology, Kansas State University Manhattan 66506, Kansas, USA.
FAU - Caldwell, Jacob T
AU  - Caldwell JT
AD  - Department of Kinesiology, Kansas State University Manhattan 66506, Kansas, USA.
FAU - Butenas, Alec L E
AU  - Butenas ALE
AD  - Department of Kinesiology, Kansas State University Manhattan 66506, Kansas, USA.
FAU - Horn, Andrew G
AU  - Horn AG
AD  - Department of Kinesiology, Kansas State University Manhattan 66506, Kansas, USA.
FAU - Kunkel, Olivia N
AU  - Kunkel ON
AD  - Department of Kinesiology, Kansas State University Manhattan 66506, Kansas, USA.
FAU - Copp, Steven W
AU  - Copp SW
AD  - Department of Kinesiology, Kansas State University Manhattan 66506, Kansas, USA.
FAU - Ade, Carl J
AU  - Ade CJ
AD  - Department of Kinesiology, Kansas State University Manhattan 66506, Kansas, USA.
AD  - Johnson Cancer Research Center, Kansas State University Manhattan 66506, Kansas, 
      USA.
FAU - Musch, Timothy I
AU  - Musch TI
AD  - Department of Kinesiology, Kansas State University Manhattan 66506, Kansas, USA.
AD  - Department of Anatomy and Physiology, Kansas State University Manhattan 66506, 
      Kansas, USA.
FAU - Behnke, Bradley J
AU  - Behnke BJ
AD  - Department of Kinesiology, Kansas State University Manhattan 66506, Kansas, USA.
AD  - Johnson Cancer Research Center, Kansas State University Manhattan 66506, Kansas, 
      USA.
LA  - eng
GR  - R15 HL137156/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20210115
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC7847523
OTO - NOTNLM
OT  - Prostate cancer
OT  - cardiac atrophy
OT  - high-intensity exercise
COIS- None.
EDAT- 2021/02/03 06:00
MHDA- 2021/02/03 06:01
PMCR- 2021/01/15
CRDT- 2021/02/02 06:10
PHST- 2020/05/26 00:00 [received]
PHST- 2020/11/20 00:00 [accepted]
PHST- 2021/02/02 06:10 [entrez]
PHST- 2021/02/03 06:00 [pubmed]
PHST- 2021/02/03 06:01 [medline]
PHST- 2021/01/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2021 Jan 15;13(1):197-209. eCollection 2021.