PMID- 33528926
OWN - NLM
STAT- MEDLINE
DCOM- 20210930
LR  - 20210930
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 49
IP  - 1
DP  - 2021
TI  - The association between seropositivity to human toxocariasis and childhood asthma 
      in northern Iran: a case-control study.
PG  - 25-31
LID - 10.15586/aei.v49i1.15 [doi]
AB  - BACKGROUND: Besides the well-known risk factors, Toxocara infection is thought to 
      play a significant etiological role in the development of childhood asthma. To 
      further explore this association, the prevalence of Toxocara infection in sera of 
      asthmatic children and healthy controls in northern Iran was investigated. 
      METHODS: In this case-control study, cases were 145 physician-confirmed asthmatic 
      children diagnosed according to the Global Initiative for Asthma (GINA) 
      guidelines. Controls were 115 age-sex-residence-matched children who did not have 
      physician-diagnosed asthma. The presence of anti-Toxocara immunoglobulin G (IgG) 
      was tested using enzyme-linked immunosorbent assay. Univariate and multivariate 
      logistic regression methods were used for case-control comparisons. RESULTS: 
      Seropositivity rate was 4.1% (95% CI, 3.4-4.7%) in asthmatic children and 0.86% 
      (95% CI, 0.71-1.0%) in controls, suggesting a strong association (P-value < 
      0.02). Moreover, Toxocara infection was not significantly more prevalent (P-value 
      = 0.12) in children with moderate sustainable asthma (9.3%, 3/32) than in 
      children with mild sustainable asthma (2.3%, 3/113). Mean total immunoglobulin E 
      (IgE) level was significantly higher in Toxocara-infected children (222.3 +/- 
      367.1) than in non-infected children (143.19 +/- 218.05) in the case group (P-value 
      < 0.05). CONCLUSIONS: Our findings indicated that Toxocara infection can play an 
      important role in childhood asthma. Further experimental and epidemiological 
      studies are needed to clarify this hypothesis.
FAU - Darvish, Sorena
AU  - Darvish S
AD  - Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
FAU - Mohammadzadeh, Iraj
AU  - Mohammadzadeh I
AD  - Non-Communicable Pediatric Diseases Research Center, Health Research Institute, 
      Babol University of Medical Sciences, Babol, Iran.
FAU - Mehravar, Saeed
AU  - Mehravar S
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tehran 
      University of Medical Science, Tehran, Iran.
FAU - Spotin, Adel
AU  - Spotin A
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Rostami, Ali
AU  - Rostami A
AD  - Infectious Diseases and Tropical Medicine Research Center, Health Research 
      Institute, Babol University of Medical Sciences, Babol, Iran; 
      a.rostami@mubabol.ac.ir; alirostami1984@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20210102
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 0 (Antibodies, Helminth)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Antibodies, Helminth/blood
MH  - Asthma/blood/*epidemiology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Iran/epidemiology
MH  - Male
MH  - Prevalence
MH  - Risk Factors
MH  - Toxocara/immunology
MH  - Toxocariasis/blood/*epidemiology
OTO - NOTNLM
OT  - ELISA
OT  - Iran
OT  - Toxocara infection
OT  - association
OT  - childhood asthma
COIS- None of the authors have any conflict of interest.
EDAT- 2021/02/03 06:00
MHDA- 2021/10/01 06:00
CRDT- 2021/02/02 12:17
PHST- 2020/05/03 00:00 [received]
PHST- 2020/10/07 00:00 [accepted]
PHST- 2021/02/02 12:17 [entrez]
PHST- 2021/02/03 06:00 [pubmed]
PHST- 2021/10/01 06:00 [medline]
AID - 10.15586/aei.v49i1.15 [doi]
PST - epublish
SO  - Allergol Immunopathol (Madr). 2021 Jan 2;49(1):25-31. doi: 10.15586/aei.v49i1.15. 
      eCollection 2021.