PMID- 33528933
OWN - NLM
STAT- MEDLINE
DCOM- 20210930
LR  - 20220420
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 49
IP  - 1
DP  - 2021
TI  - Specific IgE levels as an outcome predictor in egg-allergic children.
PG  - 79-86
LID - 10.15586/aei.v49i1.22 [doi]
AB  - BACKGROUND: Diagnosis of immunoglobulin E (IgE)-mediated egg allergy is often 
      based on both a compatible clinical history and either elevated IgE levels or a 
      positive skin prick test. However, the gold standard is the oral food challenge 
      (OFC). Previous studies have pointed to a correlation between IgE levels and OFC 
      outcomes. OBJECTIVE: This study aimed to determine the relationship between IgE 
      levels and the outcome of OFC, seeking to establish cut-off OFC values that 
      indicate a high likelihood of positive OFC results. METHODS: A total of 198 
      patients who underwent OFC (and a serological IgE antibody assay within the three 
      preceding months) were reviewed and divided by OFC type (i.e., baked, cooked, or 
      raw egg). IgE-specific levels were assessed against the challenge outcome as well 
      as cut-offs proposed by other authors. RESULTS: Receiver-operating characteristic 
      (ROC) curve analysis yielded a potentially useful ovomucoid IgE-specific cutoff 
      used in OFC with cooked egg and several egg white and ovalbumin IgE-specific 
      cut-offs for OFC with raw egg. We found no significant relationship between other 
      specific IgE concentrations and the challenge threshold level with baked eggs. 
      CONCLUSIONS: IgE-specific concentrations are useful as predictors of OFC outcome 
      and should be considered when selecting patients challenge testing with boiled or 
      raw egg. However, patients should undergo OFC with baked egg regardless of IgE 
      levels.
FAU - Rodriguez-Catalan, Jesus
AU  - Rodriguez-Catalan J
AD  - Pediatrics Department, Hospital Universitario Fundacion Jimenez Diaz, Madrid, 
      Spain; jesusrodricatalan@gmail.com.
FAU - Gonzalez-Arias, Alba Manasa
AU  - Gonzalez-Arias AM
AD  - Pediatrics Department, Hospital Universitario Fundacion Jimenez Diaz, Madrid, 
      Spain.
FAU - Casas, Almudena Vallespin
AU  - Casas AV
AD  - Pediatrics Department, Hospital Universitario Fundacion Jimenez Diaz, Madrid, 
      Spain.
FAU - Camacho, Genoveva Del Rio
AU  - Camacho GDR
AD  - Pediatrics Department, Hospital Universitario Fundacion Jimenez Diaz, Madrid, 
      Spain.
LA  - eng
PT  - Journal Article
DEP - 20210102
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Egg Hypersensitivity/blood/*diagnosis
MH  - Eggs/adverse effects
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Longitudinal Studies
MH  - Male
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Retrospective Studies
OTO - NOTNLM
OT  - IgE levels
OT  - children
OT  - cut-off value
OT  - egg allergy
OT  - oral food challenge
OT  - positive predictive value
COIS- The authors have no conflicts of interest to declare.
EDAT- 2021/02/03 06:00
MHDA- 2021/10/01 06:00
CRDT- 2021/02/02 12:17
PHST- 2020/04/03 00:00 [received]
PHST- 2020/09/13 00:00 [accepted]
PHST- 2021/02/02 12:17 [entrez]
PHST- 2021/02/03 06:00 [pubmed]
PHST- 2021/10/01 06:00 [medline]
AID - 10.15586/aei.v49i1.22 [doi]
PST - epublish
SO  - Allergol Immunopathol (Madr). 2021 Jan 2;49(1):79-86. doi: 10.15586/aei.v49i1.22. 
      eCollection 2021.