PMID- 33529479
OWN - NLM
STAT- MEDLINE
DCOM- 20210929
LR  - 20210929
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 11
IP  - 7
DP  - 2021 Jul
TI  - Clinical characteristics and cytokine profiles of central-compartment-type 
      chronic rhinosinusitis.
PG  - 1064-1073
LID - 10.1002/alr.22759 [doi]
AB  - BACKGROUND: The clinical characteristics of central-compartment-type chronic 
      rhinosinusitis (CRS) in East Asian individuals are not clear. We sought to 
      investigate the clinical features and the cytokine profiles of 
      central-compartment-type CRS in our patient group. METHODS: Adult patients 
      diagnosed with bilateral CRS were recruited, and patients who had previously 
      undergone sinus surgery and pansinusitis (Lund-Mackay scores >23) were excluded. 
      Central-compartment-type CRS was defined by both endoscopic and radiological 
      features. The symptoms, inhalant allergen sensitization status, endoscopic 
      findings, and radiological assessments were recorded and compared between 
      patients with central-compartment-type CRS and other types of CRS. We also 
      examined the extent of tissue eosinophilia and specific cytokine protein levels 
      (eosinophil cationic protein [ECP], myeloperoxidase [MPO], immunoglobulin E 
      [IgE], interleukin [IL]-4, IL-5, and IL-13) in the sinonasal tissues. RESULTS: 
      Central-compartment-type CRS was found in 16 (23.9%) patients, and 
      non-central-compartment-type CRS was found in 51 (76.1%) patients. Hyposmia or 
      anosmia as the major symptom was more common in the central-compartment-type CRS 
      group. The numbers of eosinophils in tissue and serum were significantly higher 
      in the central-compartment-type CRS patients. The presence of allergen 
      sensitization was not significantly different between groups. The levels of IL-5 
      and IL-13 were increased in middle turbinate tissues of patients with 
      central-compartment-type CRS. CONCLUSION: Central-compartment-type CRS was 
      associated with hyposmia or anosmia, eosinophilic subtypes, and elevated levels 
      of IL-5 and IL-13 in middle turbinate tissues but not necessarily correlated with 
      allergic disease in our patients.
CI  - (c) 2021 ARS-AAOA, LLC.
FAU - Lin, Yi-Tsen
AU  - Lin YT
AUID- ORCID: 0000-0002-3696-2661
AD  - Department of Otolaryngology, National Taiwan University Hospital, Taipei, 
      Taiwan.
AD  - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
FAU - Lin, Chih-Feng
AU  - Lin CF
AD  - Department of Otolaryngology, National Taiwan University Hospital, Taipei, 
      Taiwan.
FAU - Liao, Chun-Kang
AU  - Liao CK
AUID- ORCID: 0000-0002-0037-1421
AD  - Department of Otolaryngology, National Taiwan University Hospital, Taipei, 
      Taiwan.
FAU - Chiang, Bor-Luen
AU  - Chiang BL
AD  - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
FAU - Yeh, Te-Huei
AU  - Yeh TH
AD  - Department of Otolaryngology, National Taiwan University Hospital, Taipei, 
      Taiwan.
AD  - College of Medicine, National Taiwan University, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210202
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-13)
SB  - IM
MH  - Adult
MH  - Chronic Disease
MH  - Cytokines
MH  - Humans
MH  - Interleukin-13
MH  - *Nasal Polyps
MH  - *Rhinitis
MH  - *Sinusitis
OTO - NOTNLM
OT  - aeroallergens
OT  - allergic rhinitis
OT  - chronic rhinosinusitis
OT  - computed tomography
EDAT- 2021/02/03 06:00
MHDA- 2021/09/30 06:00
CRDT- 2021/02/02 17:16
PHST- 2020/11/25 00:00 [revised]
PHST- 2020/07/25 00:00 [received]
PHST- 2020/12/06 00:00 [accepted]
PHST- 2021/02/03 06:00 [pubmed]
PHST- 2021/09/30 06:00 [medline]
PHST- 2021/02/02 17:16 [entrez]
AID - 10.1002/alr.22759 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2021 Jul;11(7):1064-1073. doi: 10.1002/alr.22759. Epub 
      2021 Feb 2.