PMID- 33529682
OWN - NLM
STAT- MEDLINE
DCOM- 20211119
LR  - 20220402
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Print)
IS  - 0047-6374 (Linking)
VI  - 195
DP  - 2021 Apr
TI  - Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal 
      muscle.
PG  - 111443
LID - S0047-6374(21)00015-4 [pii]
LID - 10.1016/j.mad.2021.111443 [doi]
AB  - Caloric restriction (CR) can prolong aged skeletal muscle function, yet the 
      molecular mechanisms are not completely understood. We performed phosphoproteomic 
      analysis on muscle from young and old mice fed an ad libitum diet, and old mice 
      fed a CR diet. CR promoted a youthful phosphoproteomic signature, suppressing 
      several known "pro-aging" pathways including Protein kinase A (PKA). This study 
      validates global signaling changes in skeletal muscle during CR.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Bareja, Akshay
AU  - Bareja A
AD  - Duke Molecular Physiology Institute, Duke University Medical School, Durham, NC, 
      USA.
FAU - Draper, James A
AU  - Draper JA
AD  - Duke Molecular Physiology Institute, Duke University Medical School, Durham, NC, 
      USA.
FAU - Katz, Lauren H
AU  - Katz LH
AD  - Duke Molecular Physiology Institute, Duke University Medical School, Durham, NC, 
      USA; Adams School of Dentistry, University of North Carolina Chapel Hill, Chapel 
      Hill, NC, USA.
FAU - Lee, David E
AU  - Lee DE
AD  - Duke Molecular Physiology Institute, Duke University Medical School, Durham, NC, 
      USA.
FAU - Grimsrud, Paul A
AU  - Grimsrud PA
AD  - Duke Molecular Physiology Institute, Duke University Medical School, Durham, NC, 
      USA; Department of Medicine, Division of Endocrinology, Metabolism, and 
      Nutrition, Duke University School of Medicine, Durham, NC, USA.
FAU - White, James P
AU  - White JP
AD  - Duke Molecular Physiology Institute, Duke University Medical School, Durham, NC, 
      USA; Department of Medicine, Division of Hematology, Duke University School of 
      Medicine, Durham, NC, USA; Duke Center for Aging and Human Development, Duke 
      University School of Medicine, Durham, NC, USA. Electronic address: 
      james.white@duke.edu.
LA  - eng
GR  - K01 AG056664/AG/NIA NIH HHS/United States
GR  - P30 AG028716/AG/NIA NIH HHS/United States
GR  - T32 HL007057/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210130
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (Phosphoproteins)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Caloric Restriction/*methods
MH  - Cyclic AMP-Dependent Protein Kinases/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Muscle, Skeletal/physiology/physiopathology
MH  - Phosphoproteins/*metabolism
MH  - Principal Component Analysis/methods
MH  - Proteomics/*methods
MH  - Regeneration/physiology
MH  - Rejuvenation/*physiology
MH  - Signal Transduction
MH  - Time
PMC - PMC8035222
MID - NIHMS1674318
OTO - NOTNLM
OT  - Aging
OT  - Caloric restriction
OT  - Mice
OT  - PKA
OT  - Phosphoproteome
COIS- Conflict of interest The authors report no conflict of interest, financial or 
      otherwise.
EDAT- 2021/02/03 06:00
MHDA- 2021/11/20 06:00
PMCR- 2022/04/01
CRDT- 2021/02/02 20:09
PHST- 2020/12/02 00:00 [received]
PHST- 2021/01/22 00:00 [revised]
PHST- 2021/01/26 00:00 [accepted]
PHST- 2021/02/03 06:00 [pubmed]
PHST- 2021/11/20 06:00 [medline]
PHST- 2021/02/02 20:09 [entrez]
PHST- 2022/04/01 00:00 [pmc-release]
AID - S0047-6374(21)00015-4 [pii]
AID - 10.1016/j.mad.2021.111443 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2021 Apr;195:111443. doi: 10.1016/j.mad.2021.111443. Epub 2021 
      Jan 30.