PMID- 33530278 OWN - NLM STAT- MEDLINE DCOM- 20210212 LR - 20230103 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 100 IP - 4 DP - 2021 Jan 29 TI - Clinical features and outcome of pediatric acute lymphoblastic leukemia with low peripheral blood blast cell count at diagnosis. PG - e24518 LID - 10.1097/MD.0000000000024518 [doi] LID - e24518 AB - Peripheral blood (PB) blast cell count on day 8 of prednisone therapy has been considered one of the strongest predictors of outcome in children with acute lymphoblastic leukemia (ALL). However, little is known about the clinical features and prognostic impact of PB blast cell count at diagnosis in these patients. The aim of this study was to evaluate the relationship between initial PB blast cell count and clinical prognosis of pediatric ALL.The study comprised 367 patients with ALL, aged 0 to 14 years, enrolled and treated using the Chinese Children's Leukemia Group-ALL 2008 protocol between 2011 and 2015. The majority (91.6%) of patients were B-cell precursor ALL (BCP ALL), and 8.4% were T-cell ALL (T-ALL).Patients with BCP ALL in the low PB blast cell count group (<1 x 109/L) had significantly superior survival rates to those in the high count group (>/=30 x 109/L). In T-ALL, the low count group showed significantly inferior survival rates compared to both the intermediate count group (1-29.9 x 109/L) and high count group. Multivariate analysis revealed that the initial white blood cell count and minimal residual disease at the end of induction therapy were independently predictive of BCP ALL outcome, while risk stratification was shown to be an independent prognostic factor for T-ALL outcome.These results indicated that low blast cell count in PB at diagnosis was associated with different clinical outcomes in patients with BCP ALL and T-ALL, although it was not an independent outcome predictor by multivariate analysis. CI - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Dai, Qingkai AU - Dai Q AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - Zhang, Ge AU - Zhang G AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - Yang, Hui AU - Yang H AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - Wang, Yuefang AU - Wang Y AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - Ye, Lei AU - Ye L AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - Peng, Luyun AU - Peng L AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - Shi, Rui AU - Shi R AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - Guo, Siqi AU - Guo S AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - He, Jiajing AU - He J AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. FAU - Jiang, Yongmei AU - Jiang Y AUID- ORCID: 0000-0002-0487-1888 AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China. LA - eng PT - Journal Article PT - Observational Study PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Antineoplastic Agents, Hormonal) RN - VB0R961HZT (Prednisone) SB - IM MH - Adolescent MH - Antineoplastic Agents, Hormonal/therapeutic use MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Infant, Newborn MH - Leukocyte Count MH - Male MH - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*blood/drug therapy MH - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*blood/drug therapy/mortality MH - Prednisone/therapeutic use MH - Progression-Free Survival MH - Retrospective Studies MH - Risk Assessment MH - Time Factors PMC - PMC7850651 COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2021/02/04 06:00 MHDA- 2021/02/13 06:00 PMCR- 2021/01/29 CRDT- 2021/02/03 01:01 PHST- 2020/06/09 00:00 [received] PHST- 2021/01/08 00:00 [accepted] PHST- 2021/02/03 01:01 [entrez] PHST- 2021/02/04 06:00 [pubmed] PHST- 2021/02/13 06:00 [medline] PHST- 2021/01/29 00:00 [pmc-release] AID - 00005792-202101290-00128 [pii] AID - MD-D-20-05566 [pii] AID - 10.1097/MD.0000000000024518 [doi] PST - ppublish SO - Medicine (Baltimore). 2021 Jan 29;100(4):e24518. doi: 10.1097/MD.0000000000024518.