PMID- 33531615
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20211115
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Feb 2
TI  - Systematic review with network meta-analysis of antivascular endothelial growth 
      factor use in managing polypoidal choroidal vasculopathy.
PG  - 2735
LID - 10.1038/s41598-021-82316-y [doi]
LID - 2735
AB  - Polypoidal choroidal vasculopathy (PCV) is a vision-threatening disease common in 
      Asian populations. However, the optimal treatment for PCV remains under debate. 
      We searched the databases with optimal searching strategy. The study included 
      randomized clinical trials and prospective studies that recruited patients with 
      active PCV who had received interventions, including PDT, anti-VEGF, or a 
      combination of PDT and anti-VEGF. The Grading of Recommendations Assessment, 
      Development, and Evaluation methodology was used for rating the quality of 
      evidence. Our study included 11 studies involving 1277 patients. The network 
      meta-analysis of RCTs revealed the anti-VEGF group, early combination group, and 
      late combination group had significant BCVA changes compared with the PDT group. 
      Early combination therapy led to a significant decrease in CRT compared with PDT, 
      anti-VEGF, and late combination therapy. Additionally, the early combination 
      group had a significantly higher complete polyp regression rate than the 
      anti-VEGF group. No significant differences were detected in the analysis of the 
      number of anti-VEGF injections and safety profile. This network meta-analysis 
      revealed that early combination therapy exhibited better efficacy related to 
      anatomical outcomes than other therapies. Nonetheless, no significant differences 
      related to BCVA change could be detected between anti-VEGF and late combination 
      therapy.
FAU - Chi, Sheng-Chu
AU  - Chi SC
AD  - Department of Ophthalmology, Taiwan Faculty of Medicine, Taipei Veterans General 
      Hospital, Taipei, Taiwan.
FAU - Kang, Yi-No
AU  - Kang YN
AD  - Evidence-Based Medicine Center, Wan Fang Hospital, Taipei Medical University, 
      Taipei, Taiwan.
AD  - Research Center of Big Data and Meta-Analysis, Wan Fang Hospital, Taipei Medical 
      University, Taipei, Taiwan.
AD  - Cochrane Taiwan, Taipei Medical University, Taipei, Taiwan.
AD  - Institute of Health Policy and Management, College of Public Health, National 
      Taiwan University, Taipei, Taiwan.
FAU - Huang, Yi-Ming
AU  - Huang YM
AD  - Department of Ophthalmology, Taiwan Faculty of Medicine, Taipei Veterans General 
      Hospital, Taipei, Taiwan. nowaytokyo@yahoo.com.tw.
AD  - National Yang-Ming University School of Medicine, Taipei, Taiwan. 
      nowaytokyo@yahoo.com.tw.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Systematic Review
DEP - 20210202
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Photosensitizing Agents)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Angiogenesis Inhibitors/*administration & dosage/adverse effects
MH  - Choroid/blood supply/drug effects/pathology
MH  - Choroidal Neovascularization/*drug therapy/pathology
MH  - Humans
MH  - Intravitreal Injections
MH  - Network Meta-Analysis
MH  - Photochemotherapy/adverse effects/*methods
MH  - Photosensitizing Agents/administration & dosage/adverse effects
MH  - Polyps/*drug therapy/pathology
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
MH  - Vascular Endothelial Growth Factor A/*antagonists & inhibitors
PMC - PMC7854625
COIS- The authors declare no competing interests
EDAT- 2021/02/04 06:00
MHDA- 2021/11/16 06:00
PMCR- 2021/02/02
CRDT- 2021/02/03 05:54
PHST- 2020/10/08 00:00 [received]
PHST- 2021/01/19 00:00 [accepted]
PHST- 2021/02/03 05:54 [entrez]
PHST- 2021/02/04 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/02/02 00:00 [pmc-release]
AID - 10.1038/s41598-021-82316-y [pii]
AID - 82316 [pii]
AID - 10.1038/s41598-021-82316-y [doi]
PST - epublish
SO  - Sci Rep. 2021 Feb 2;11(1):2735. doi: 10.1038/s41598-021-82316-y.