PMID- 33532028
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210206
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 14
IP  - 1
DP  - 2021
TI  - Role of HPV status and PD-L1 expression in prognosis of laryngeal squamous cell 
      carcinoma.
PG  - 107-115
AB  - PURPOSE: Human papillomavirus (HPV) infection has been recognized as a cause of 
      head and neck squamous cell carcinomas (HNSCC). Laryngeal squamous cell carcinoma 
      (LSCC) is one of the most common pathologic types of HNSCC. Clinical trials show 
      that there are differences in response to immunotherapy according to HPV status. 
      It was reported that a high level of programmed cell death-ligand 1 (PD-L1) is 
      correlated with better survival in HPV-positive head and neck cancer. In this 
      study, we investigated the expression of PD-L1 in HPV-positive and HPV-negative 
      LSCC to determine its prevalence and prognostic value. METHODS: 52 cases of LSCC 
      were collected from Tangshan Head and Neck Disease Pathology Research Base. 
      PCR-reverse dot blot hybridization and RNAscope in situ hybridization were used 
      to detect HPV status. PD-L1 expression was evaluated by immunohistochemistry and 
      all cases were followed up for survival. SPSS24.0 was used for data entry and 
      statistical analysis. Kaplan-Meier method and Log-rank time series analysis were 
      used for single factor analysis. Multivariate analysis was performed using Cox 
      proportional hazard regression model, and HR and 95% CI were calculated. RESULTS: 
      Of the 52 LSCC patients, 32.7% (17/52) were HPV-positive by RNAscope in situ 
      hybridization, and 51.9% (27/52) of patients were positive for PD-L1 expression 
      by immunohistochemistry. Regression analysis showed that with a median follow-up 
      period of 69 months, smoking and late stage were associated with poor overall 
      survival (OS), whereas HPV positivity and PD-L1 expression showed a better 
      overall survival outcome. CONCLUSION: Smoking status, tumor stage, HPV status, 
      and PD-L1 expression in tumor cells may represent useful prognostic biomarkers in 
      patients with LSCC.
CI  - IJCEP Copyright (c) 2021.
FAU - Yang, Su-Mei
AU  - Yang SM
AD  - Department of Pneumology, Tangshan People's Hospital Tangshan, P. R. China.
FAU - Wu, Meng
AU  - Wu M
AD  - Department of Pathology, Division of Basic Medicine, Tangshan Vocational and 
      Technical College Tangshan, P. R. China.
FAU - Han, Feng-Yan
AU  - Han FY
AD  - Department of Pathology, Tangshan Union Hospital Tangshan, P. R. China.
FAU - Sun, Yu-Man
AU  - Sun YM
AD  - Department of Pathology, Tangshan Union Hospital Tangshan, P. R. China.
FAU - Yang, Jun-Quan
AU  - Yang JQ
AD  - Department of Radio-chemotherapy Oncology, Tangshan People's Hospital Tangshan, 
      P. R. China.
FAU - Liu, Hong-Xia
AU  - Liu HX
AD  - Department of Pathology, Tangshan Union Hospital Tangshan, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20210101
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC7847499
OTO - NOTNLM
OT  - Human papillomavirus
OT  - Laryngeal squamous cell carcinoma
OT  - prognosis
OT  - programmed death ligand 1
COIS- None.
EDAT- 2021/02/04 06:00
MHDA- 2021/02/04 06:01
PMCR- 2021/01/01
CRDT- 2021/02/03 05:58
PHST- 2020/11/05 00:00 [received]
PHST- 2020/11/26 00:00 [accepted]
PHST- 2021/02/03 05:58 [entrez]
PHST- 2021/02/04 06:00 [pubmed]
PHST- 2021/02/04 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2021 Jan 1;14(1):107-115. eCollection 2021.