PMID- 33532336 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210206 IS - 2223-4691 (Print) IS - 2223-4691 (Electronic) IS - 2223-4683 (Linking) VI - 10 IP - 1 DP - 2021 Jan TI - Comparison of single-use and reusable flexible ureteroscope for renal stone management: a pooled analysis of 772 patients. PG - 483-493 LID - 10.21037/tau-20-1009 [doi] AB - Flexible ureteroscopy is a common therapy for patients with renal calculi. In recent years, the prevalence of single-use flexible ureteroscope (FURS) use has been on the rise. Thus, several trials have been conducted to compare the efficacy between single-use and reusable FURS. The aim of this meta-analysis was to systematically assess the effectiveness and safety of single-use vs. reusable FURS in treating renal stones. PubMed, Web of Science, Cochrane Library and EMBASE were researched to identify relevant studies up to September 2019. Article selection was performed through the search strategy based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. The Newcastle-Ottawa Scale was applied to assess the methodological quality of non-randomized controlled trials, and the methodological quality of randomized controlled trials was evaluated using the Jadad scale. A total of five studies with 772 patients were included in the meta-analysis, including two randomized controlled trials, two single-centre prospective studies, and one prospective case-control trial. The pooled results showed that single-use FURS was associated with a higher stone-free rate (SFR) (OR: 1.50; 95% CI, 1.06-2.12; P=0.02) than reusable FURS. A significant difference was noted in operative time, and single-use FURS was associated with a longer operative duration (MD: 7.39 min; 95% CI, 1.75-13.03; P=0.01). No significant difference was noted in perioperative complications (OR: 0.97; 95% CI, 0.56-1.70; P=0.92). Subgroup analysis showed no significant difference in urinary tract infection (OR: 0.80; 95% CI, 0.44-1.46; P=0.46), stent migration (OR: 0.56; 95% CI, 0.19-1.65; P=0.30) or acute kidney injury (OR: 0.76; 95% CI, 0.16-3.57; P=0.73). Single-use FURS is an effective and safe alternative to reusable FURS for the management of renal stones. CI - 2021 Translational Andrology and Urology. All rights reserved. FAU - Li, Yongchao AU - Li Y AD - Department of Urology, Xiangya Hospital, Central South University, Changsha, China. FAU - Chen, Jinbo AU - Chen J AD - Department of Urology, Xiangya Hospital, Central South University, Changsha, China. FAU - Zhu, Zewu AU - Zhu Z AD - Department of Urology, Xiangya Hospital, Central South University, Changsha, China. FAU - Zeng, Huimin AU - Zeng H AD - Department of Urology, Xiangya Hospital, Central South University, Changsha, China. FAU - Zeng, Feng AU - Zeng F AD - Department of Urology, Xiangya Hospital, Central South University, Changsha, China. FAU - Chen, Zhiyong AU - Chen Z AD - Department of Urology, Xiangya Hospital, Central South University, Changsha, China. FAU - Yang, Zhongqing AU - Yang Z AD - Department of Urology, Xiangya Hospital, Central South University, Changsha, China. FAU - Cui, Yu AU - Cui Y AD - Department of Urology, Xiangya Hospital, Central South University, Changsha, China. FAU - Chen, Hequn AU - Chen H AD - Department of Urology, Xiangya Hospital, Central South University, Changsha, China. FAU - Li, Yang AU - Li Y AD - Department of Urology, Xiangya Hospital, Central South University, Changsha, China. LA - eng PT - Journal Article PT - Review PL - China TA - Transl Androl Urol JT - Translational andrology and urology JID - 101581119 PMC - PMC7844498 OTO - NOTNLM OT - Renal stones OT - reusable flexible ureteroscope OT - single-use flexible ureteroscope COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tau-20-1009). The authors have no other conflicts of interest to declare. EDAT- 2021/02/04 06:00 MHDA- 2021/02/04 06:01 PMCR- 2021/01/01 CRDT- 2021/02/03 05:59 PHST- 2021/02/03 05:59 [entrez] PHST- 2021/02/04 06:00 [pubmed] PHST- 2021/02/04 06:01 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - tau-10-01-483 [pii] AID - 10.21037/tau-20-1009 [doi] PST - ppublish SO - Transl Androl Urol. 2021 Jan;10(1):483-493. doi: 10.21037/tau-20-1009.