PMID- 33532626
OWN - NLM
STAT- MEDLINE
DCOM- 20211019
LR  - 20240330
IS  - 2398-9238 (Electronic)
IS  - 2398-9238 (Linking)
VI  - 4
IP  - 1
DP  - 2021 Jan
TI  - Magnesium dietary intake and physical activity in Type 2 diabetes by gender in 
      White, African-American and Mexican American: NHANES 2011-2014.
PG  - e00203
LID - 10.1002/edm2.203 [doi]
LID - e00203
AB  - AIMS: To analyse the causal relationships of nutrition intake and physical 
      activity on haemoglobin A1c (HbA1C) in patients diagnosed with type 2 diabetes 
      mellitus (T2DM) stratified by gender and ethnicity. MATERIALS AND METHODS: An 
      historical cohort of patients with diagnosed T2DM (n = 2831) was extracted from 
      the National Health and Nutrition Examination Survey (NHANES) 2011-2014 public 
      database, including but not limited to, measurements of physical activity, 
      nutrition, body mass index (BMI) and HbA1c. Multivariate analyses and path 
      analyses were employed to estimate the regression coefficients and path 
      coefficients (rho) of causal path models of physical activity and nutrition intake 
      on HbA1c stratified by gender and three ethnicity groups (ie non-Hispanic white, 
      non-Hispanic black and Mexican American). RESULTS: A significant causal path from 
      increased physical activity to increased magnesium (Mg) intake to decreased HbA1c 
      was found. In addition, increased physical activity significantly decreased BMI, 
      which further decreased HbA1c. These results varied by gender and ethnicity but 
      were directionally consistent. Physical activity decreased HbA1c through BMI for 
      males and through Mg intake for females. Mexican American decreased HbA1c through 
      Mg intake, while non-Hispanic black had an increased HbA1c due to its ethnicity 
      and through increased BMI. CONCLUSIONS: The beneficial effects of physical 
      activity on decreased HbA1c were mediated through the increased Mg intake and 
      decreased BMI. This aligned with recent investigations of the inverse causal 
      association of Mg intake with insulin resistance and with decreased inflammation.
CI  - (c) 2020 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley 
      & Sons Ltd.
FAU - Wu, You
AU  - Wu Y
AUID- ORCID: 0000-0003-4537-6530
AD  - Global Biostatistics Science Center for Design and Analysis Amgen Inc. Thousand 
      Oaks CA USA.
AD  - Department of Bioinformatics and Biostatistics School of Public Health and 
      Information Sciences University of Louisville Louisville KY USA.
FAU - Datta, Susmita
AU  - Datta S
AUID- ORCID: 0000-0002-7408-699X
AD  - Department of Biostatistics, College of Public Health & Health Professions and 
      College of Medicine University of Florida 2004 Mowry Rd Gainesville United States 
      FL 32611-7450 USA.
FAU - Little, Bert B
AU  - Little BB
AUID- ORCID: 0000-0002-6485-4641
AD  - Department of Health Management and Systems Sciences School of Public Health and 
      Information Sciences University of Louisville Louisville KY USA.
FAU - Kong, Maiying
AU  - Kong M
AUID- ORCID: 0000-0002-7313-9084
AD  - Department of Bioinformatics and Biostatistics School of Public Health and 
      Information Sciences University of Louisville Louisville KY USA.
LA  - eng
PT  - Journal Article
DEP - 20201120
PL  - England
TA  - Endocrinol Diabetes Metab
JT  - Endocrinology, diabetes & metabolism
JID - 101732442
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Magnesium Compounds)
RN  - 0 (hemoglobin A1c protein, human)
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - Cohort Studies
MH  - *Datasets as Topic
MH  - Diabetes Mellitus, Type 2/blood/*ethnology/metabolism/*physiopathology
MH  - Eating/*physiology
MH  - Exercise/*physiology
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Insulin Resistance
MH  - Magnesium Compounds/*administration & dosage
MH  - Male
MH  - Middle Aged
MH  - *Racial Groups
MH  - *Sex Characteristics
MH  - Young Adult
PMC - PMC7831210
OTO - NOTNLM
OT  - NHANES
OT  - T2DM
OT  - magnesium intake
OT  - path analysis
OT  - physical activity
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/02/04 06:00
MHDA- 2021/02/04 06:01
PMCR- 2020/11/20
CRDT- 2021/02/03 06:00
PHST- 2020/06/05 00:00 [received]
PHST- 2020/09/17 00:00 [revised]
PHST- 2020/10/24 00:00 [accepted]
PHST- 2021/02/03 06:00 [entrez]
PHST- 2021/02/04 06:00 [pubmed]
PHST- 2021/02/04 06:01 [medline]
PHST- 2020/11/20 00:00 [pmc-release]
AID - EDM2203 [pii]
AID - 10.1002/edm2.203 [doi]
PST - epublish
SO  - Endocrinol Diabetes Metab. 2020 Nov 20;4(1):e00203. doi: 10.1002/edm2.203. 
      eCollection 2021 Jan.