PMID- 33533228
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 2411-2097 (Electronic)
IS  - 0507-4088 (Linking)
VI  - 65
IP  - 6
DP  - 2021 Jan 7
TI  - [The role of herpesviruses in development of diseases of the urogenital tract and 
      infertility in women].
PG  - 317-325
LID - 10.36233/0507-4088-2020-65-6-2 [doi]
AB  - This review presents the data on the spreading of all known human herpesviruses 
      (capital EN, CyrillicHVs) in female urogenital tract. According to the WHO almost 500 million people 
      worldwide suffer from genital infection caused by capital EN, CyrillicHVs. capital EN, CyrillicHVs were detected in 
      various inflammatory diseases of female upper and lower genital tract (vaginitis 
      and cervicitis), in extrauterine pregnancy (in fallopian tubes), in infertility 
      (cervical channel, endometrium and ovaries). Herpes simplex virus 1 (HSV‑1) was 
      identified for the first time in oocytes after failed in vitro fertilization 
      (IVF). capital EN, CyrillicHVs produce negative effect on the entire reproductive process from 
      conception to childbirth. It was established that HSV, cytomegalovirus (CMV) and 
      human herpesvirus 6 (HHV-6) markedly increase the risk of spontaneous abortion, 
      preterm birth and stillbirth. Intrauterine capital EN, CyrillicHV infection is a major cause of 
      congenital malformations. Data on humoral and cell immunity in genital 
      herpesvirus infections (capital EN, CyrillicHVI) are also reviewed. Intravaginal HSV‑2 infection 
      changes cell composition of vaginal mucosa, i.e., together with cells mobilized 
      from the blood, protective role is performed by resident memory T‑cells (TRM), 
      natural killer cells (NK‑cells) and regulatory T‑cells (Treg) whose function 
      consists in maintaining the balance of the activities of lymphocytes. Constant 
      capital EN, CyrillicHVI spreading is largely explained by transition of primary infection to 
      potentially reactivating latent form, since latent virus is unavailable to immune 
      recognition and medicines. The genome editing system CRISPR/Cas9 can recognize 
      and modify not only active but also latent viruses. The promising pilot results 
      with the use of this system offer the possibility of developing innovative 
      technologies for capital EN, CyrillicHV elimination and capital EN, CyrillicHVI eradication.
FAU - Kushch, A A
AU  - Kushch AA
AD  - Ivanovsky Institute of Virology of FSBI <<National Research Centre of Epidemiology 
      and Microbiology named after honorary academician N.F. Gamaleya>> of the Ministry 
      of Health of Russia.
FAU - Kisteneva, L B
AU  - Kisteneva LB
AD  - Ivanovsky Institute of Virology of FSBI <<National Research Centre of Epidemiology 
      and Microbiology named after honorary academician N.F. Gamaleya>> of the Ministry 
      of Health of Russia.
FAU - Klimova, R R
AU  - Klimova RR
AD  - Ivanovsky Institute of Virology of FSBI <<National Research Centre of Epidemiology 
      and Microbiology named after honorary academician N.F. Gamaleya>> of the Ministry 
      of Health of Russia.
FAU - Cheshik, S G
AU  - Cheshik SG
AD  - Ivanovsky Institute of Virology of FSBI <<National Research Centre of Epidemiology 
      and Microbiology named after honorary academician N.F. Gamaleya>> of the Ministry 
      of Health of Russia.
LA  - rus
PT  - Journal Article
PT  - Review
DEP - 20210107
PL  - Russia (Federation)
TA  - Vopr Virusol
JT  - Voprosy virusologii
JID - 0417337
SB  - IM
MH  - Female
MH  - Herpes Genitalis/epidemiology/*virology
MH  - Herpesviridae/classification/genetics/*pathogenicity
MH  - Herpesvirus 1, Human/pathogenicity
MH  - Herpesvirus 2, Human/pathogenicity
MH  - Herpesvirus 6, Human/pathogenicity
MH  - Humans
MH  - Infertility, Female/epidemiology/*virology
MH  - Pregnancy
MH  - Premature Birth/epidemiology/virology
MH  - Reproductive Tract Infections/epidemiology/*virology
EDAT- 2021/02/04 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/02/03 06:08
PHST- 2021/01/07 00:00 [received]
PHST- 2021/01/07 00:00 [accepted]
PHST- 2021/02/03 06:08 [entrez]
PHST- 2021/02/04 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
AID - 10.36233/0507-4088-2020-65-6-2 [doi]
PST - epublish
SO  - Vopr Virusol. 2021 Jan 7;65(6):317-325. doi: 10.36233/0507-4088-2020-65-6-2.