PMID- 33533285
OWN - NLM
STAT- MEDLINE
DCOM- 20211124
LR  - 20211124
IS  - 1541-2563 (Electronic)
IS  - 1541-2563 (Linking)
VI  - 18
IP  - 1
DP  - 2021 Feb
TI  - Minimal Clinically Important Difference for Quadriceps Muscle Strength in People 
      with COPD following Pulmonary Rehabilitation.
PG  - 35-44
LID - 10.1080/15412555.2021.1874897 [doi]
AB  - Quadriceps strength training is a key component of pulmonary rehabilitation (PR). 
      Clinical interpretability of changes in muscle strength following PR is however 
      limited due to the lack of cut-off values to define clinical improvement. This 
      study estimated the minimal clinically important difference (MCID) for the 
      isotonic and isometric quadriceps muscle strength assessed with the 
      one-repetition maximum (1RM) and hand-held dynamometry (HHD) in people with 
      chronic obstructive pulmonary disease (COPD) following PR.A secondary analysis of 
      a real life non-randomised controlled study was conducted in people with COPD 
      enrolled in a 12-week community-based PR programme. Anchor and distribution-based 
      methods were used to compute the MCIDs. The anchors explored were the St. 
      George's respiratory questionnaire (SGRQ) and the six-minute walk test (6MWT) 
      using Pearson's correlations. Pooled MCIDs were computed using the arithmetic 
      weighted mean (2/3 anchor, 1/3 distribution-based methods) and reported as 
      absolute and/or percentage of change values.Eighty-nine people with COPD (84% 
      male, 69.9 +/- 7.9 years, FEV(1) 49.9 +/- 18.9% predicted) were included. No 
      correlations were found between changes in 1RM and the SGRQ neither between 
      changes in HHD and the SGRQ and 6MWT (p > 0.05). Thus, anchor-based methods were 
      used only in the MCID of the 1RM with the 6MWT as the anchor. The pooled MCIDs 
      were 5.7Kg and 26.9% of change for the isotonic quadriceps muscle strength with 
      1RM and 5.2KgF for isometric quadriceps muscle strength assessed with HHD.The 
      MCIDs found are estimates to improve interpretability of community-based PR 
      effects on quadriceps muscle strength and may contribute to guide interventions.
FAU - Oliveira, Ana
AU  - Oliveira A
AUID- ORCID: 0000-0003-4516-6904
AD  - School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
AD  - Respiratory Medicine, West Park Healthcare Centre, Toronto, ON, Canada.
AD  - Lab3R - Respiratory Research and Rehabilitation Laboratory, School of Health 
      Sciences, University of Aveiro (ESSUA), Aveiro, Portugal.
FAU - Rebelo, Patricia
AU  - Rebelo P
AUID- ORCID: 0000-0002-1042-8356
AD  - Lab3R - Respiratory Research and Rehabilitation Laboratory, School of Health 
      Sciences, University of Aveiro (ESSUA), Aveiro, Portugal.
AD  - iBiMED - Institute of Biomedicine, Department of Medical Sciences, University of 
      Aveiro, Aveiro, Portugal.
FAU - Paixao, Catia
AU  - Paixao C
AUID- ORCID: 0000-0002-5896-6209
AD  - Lab3R - Respiratory Research and Rehabilitation Laboratory, School of Health 
      Sciences, University of Aveiro (ESSUA), Aveiro, Portugal.
AD  - iBiMED - Institute of Biomedicine, Department of Medical Sciences, University of 
      Aveiro, Aveiro, Portugal.
FAU - Jacome, Cristina
AU  - Jacome C
AUID- ORCID: 0000-0002-1151-8791
AD  - CINTESIS -Center for Health Technology and Services Research, Faculty of 
      Medicine, University of Porto, Porto, Portugal.
AD  - Department of Community Medicine, Information and Health Decision Sciences 
      (MEDCIDS), Faculty of Medicine, University of Porto, Porto, Portugal.
FAU - Cruz, Joana
AU  - Cruz J
AUID- ORCID: 0000-0002-4911-4469
AD  - School of Health Sciences, Polytechnic Institute of Leiria, Leiria, Portugal; 
      Centre for Innovative Care and Health Technology (ciTechCare), School of Health 
      Sciences (ESSLei), Polytechnic of Leiria, Leiria, Portugal.
FAU - Martins, Vitoria
AU  - Martins V
AD  - Pulmonology Department, Hospital Distrital da Figueira da Foz, Figueira da Foz, 
      Portugal.
FAU - Simao, Paula
AU  - Simao P
AUID- ORCID: 0000-0003-0070-2793
AD  - Pulmonology Department, Unidade Local de Saude de Matosinhos, Matosinhos, 
      Portugal.
FAU - Brooks, Dina
AU  - Brooks D
AUID- ORCID: 0000-0001-6080-5052
AD  - School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
AD  - Respiratory Medicine, West Park Healthcare Centre, Toronto, ON, Canada.
FAU - Marques, Alda
AU  - Marques A
AUID- ORCID: 0000-0003-4980-6200
AD  - Lab3R - Respiratory Research and Rehabilitation Laboratory, School of Health 
      Sciences, University of Aveiro (ESSUA), Aveiro, Portugal.
AD  - iBiMED - Institute of Biomedicine, Department of Medical Sciences, University of 
      Aveiro, Aveiro, Portugal.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210203
PL  - England
TA  - COPD
JT  - COPD
JID - 101211769
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - *Minimal Clinically Important Difference
MH  - Muscle Strength
MH  - *Pulmonary Disease, Chronic Obstructive
MH  - Quadriceps Muscle
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - 1-repetition maximum
OT  - Quadriceps muscle strength
OT  - hand held dynamometry
OT  - minimal important difference
EDAT- 2021/02/04 06:00
MHDA- 2021/11/25 06:00
CRDT- 2021/02/03 08:37
PHST- 2021/02/04 06:00 [pubmed]
PHST- 2021/11/25 06:00 [medline]
PHST- 2021/02/03 08:37 [entrez]
AID - 10.1080/15412555.2021.1874897 [doi]
PST - ppublish
SO  - COPD. 2021 Feb;18(1):35-44. doi: 10.1080/15412555.2021.1874897. Epub 2021 Feb 3.