PMID- 33533549
OWN - NLM
STAT- MEDLINE
DCOM- 20210610
LR  - 20210610
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 63
IP  - 5
DP  - 2021 May
TI  - Investigating the possible association between NLRP3 gene polymorphisms and 
      myasthenia gravis.
PG  - 730-736
LID - 10.1002/mus.27193 [doi]
AB  - INTRODUCTION: In this case-control study, we investigated the association between 
      nucleotide oligomerization domain-like receptor family pyrin domain containing 3 
      (NLRP3) single-nucleotide polymorphisms (SNPs) rs10754558, rs3806265, rs4612666, 
      and rs35829419 and myasthenia gravis (MG). METHODS: Samples from MG patients were 
      selected from a previous study conducted in our neuromuscular clinic, which 
      investigated the association between human leukocyte antigen (HLA) class II genes 
      and MG. Genetic data of controls were also available from another study. The 
      NLRP3 SNPs genotyping was performed using the TaqMan method. RESULTS: A total of 
      93 blood samples from eligible Iranian patients with MG and 56 samples from 
      healthy controls were obtained. The NLRP3 rs3806265 "C" allele was significantly 
      more frequent in MG patients (P < .001; odd ratio [OR] = 2.33, 95% confidence 
      interval [CI]: 1.4-4.0) than controls. The "CC" genotype of this SNP was found in 
      18.27% of patients, but none of the controls (P < .001). The distribution of 
      other SNPs was similar between the groups. DISCUSSION: These preliminary results 
      suggest that there might be some associations between the NLRP3 gene polymorphism 
      and MG.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Agah, Elmira
AU  - Agah E
AD  - Iranian Center of Neurological Research, Neuroscience Institute, Tehran 
      University of Medical Sciences, Tehran, Iran.
AD  - Students' Scientific Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
AD  - NeuroImmunology Research Association (NIRA), Universal Scientific Education and 
      Research Network (USERN), Tehran, Iran.
FAU - Nafissi, Shahriar
AU  - Nafissi S
AUID- ORCID: 0000-0003-4763-4310
AD  - Iranian Center for Neurological Research, Department of Neurology, Shariati 
      Hospital, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Saleh, Fatemeh
AU  - Saleh F
AD  - Iranian Center of Neurological Research, Neuroscience Institute, Tehran 
      University of Medical Sciences, Tehran, Iran.
AD  - Students' Scientific Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
AD  - NeuroImmunology Research Association (NIRA), Universal Scientific Education and 
      Research Network (USERN), Tehran, Iran.
FAU - Sarraf, Payam
AU  - Sarraf P
AD  - Iranian Center of Neurological Research, Neuroscience Institute, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Tafakhori, Abbas
AU  - Tafakhori A
AD  - Iranian Center of Neurological Research, Neuroscience Institute, Tehran 
      University of Medical Sciences, Tehran, Iran.
AD  - NeuroImmunology Research Association (NIRA), Universal Scientific Education and 
      Research Network (USERN), Tehran, Iran.
FAU - Mousavi, Seyed Vahid
AU  - Mousavi SV
AD  - Students' Scientific Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
AD  - NeuroImmunology Research Association (NIRA), Universal Scientific Education and 
      Research Network (USERN), Tehran, Iran.
FAU - Saghazadeh, Amene
AU  - Saghazadeh A
AD  - Students' Scientific Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
AD  - Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific 
      Education and Research Network (USERN), Tehran, Iran.
FAU - Sadr, Maryam
AU  - Sadr M
AD  - Molecular Immunology Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Sinaei, Farnaz
AU  - Sinaei F
AD  - Department of Neurology, Shariati Hospital, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Mohebbi, Bahareh
AU  - Mohebbi B
AUID- ORCID: 0000-0002-7219-9923
AD  - Molecular Immunology Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Mahmoudi, Mahdi
AU  - Mahmoudi M
AD  - Rheumatology Research Center (RRC), Shariati Hospital, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Shadi, Hamideh
AU  - Shadi H
AD  - Iranian Center of Neurological Research, Neuroscience Institute, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Rezaei, Nima
AU  - Rezaei N
AD  - Research Center for Immunodeficiencies, Children's Medical Center, Tehran 
      University of Medical Sciences, Tehran, Iran.
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
AD  - Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal 
      Scientific Education and Research Network (USERN), Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210218
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myasthenia Gravis/*genetics
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/*genetics
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - NLRP3
OT  - inflammasome
OT  - myasthenia gravis
OT  - single-nucleotide polymorphisms
EDAT- 2021/02/04 06:00
MHDA- 2021/06/11 06:00
CRDT- 2021/02/03 08:39
PHST- 2021/01/26 00:00 [revised]
PHST- 2019/08/08 00:00 [received]
PHST- 2021/01/31 00:00 [accepted]
PHST- 2021/02/04 06:00 [pubmed]
PHST- 2021/06/11 06:00 [medline]
PHST- 2021/02/03 08:39 [entrez]
AID - 10.1002/mus.27193 [doi]
PST - ppublish
SO  - Muscle Nerve. 2021 May;63(5):730-736. doi: 10.1002/mus.27193. Epub 2021 Feb 18.