PMID- 33534599
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20210223
LR  - 20210223
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 37
IP  - 6
DP  - 2021 Feb 16
TI  - Effect of Detergents on Morphology, Size Distribution, and Concentration of 
      Copolymer-Based Polymersomes.
PG  - 2079-2090
LID - 10.1021/acs.langmuir.0c03044 [doi]
AB  - Polymersomes made of amphiphilic diblock copolymers are generally regarded as 
      having higher physical and chemical stability than liposomes composed of 
      phospholipids. This enhanced stability arises from the higher molecular weight of 
      polymer constituents. Despite their increased stability, polymer bilayers are 
      solubilized by detergents in a similar manner to lipid bilayers. In this work, we 
      evaluated the stability of poly(ethylene glycol)-block-poly(epsilon-caprolactone) 
      (PEG-PCL)-based polymersomes exposed to three different detergents: 
      N-octyl-beta-d-glucopyranoside (OG), lauryldimethylamine N-oxide (LDAO), and Triton 
      X-100 (TX-100). Changes in morphology, particle size distribution, and 
      concentrations of the polymersomes were evaluated during the titration of the 
      detergents into the polymersome solutions. Furthermore, we discussed the effect 
      of detergent features on the solubilization of the polymeric bilayer and compared 
      it to the results reported in the literature for liposomes and polymersomes. This 
      information can be used for tuning the properties of PEG-PCL polymersomes for use 
      in applications such as drug delivery or protein reconstitution studies.
FAU - Gorecki, Radoslaw
AU  - Gorecki R
AUID- ORCID: 0000-0003-0149-6880
AD  - Department of Environmental Engineering, Technical University of Denmark, 
      Bygningstorvet 115, 2800 Kongens Lyngby, Denmark.
AD  - Aquaporin A/S, Nymollevej 78, 2800 Kongens Lyngby, Denmark.
FAU - Antenucci, Fabio
AU  - Antenucci F
AD  - Department of Veterinary and Animal Sciences, University of Copenhagen, 
      Dyrlaegevej 88, 1870 Frederiksberg C, Denmark.
FAU - Norinkevicius, Karolis
AU  - Norinkevicius K
AD  - Aquaporin A/S, Nymollevej 78, 2800 Kongens Lyngby, Denmark.
AD  - Department of Chemical and Biochemical Engineering, Technical University of 
      Denmark, Soltofts Plads 228A, 2800 Kongens Lyngby, Denmark.
FAU - Elmstrom Christiansen, Line
AU  - Elmstrom Christiansen L
AD  - Aquaporin A/S, Nymollevej 78, 2800 Kongens Lyngby, Denmark.
FAU - Myers, Scott Treven
AU  - Myers ST
AD  - Aquaporin A/S, Nymollevej 78, 2800 Kongens Lyngby, Denmark.
FAU - Trzaskus, Krzysztof
AU  - Trzaskus K
AD  - Aquaporin A/S, Nymollevej 78, 2800 Kongens Lyngby, Denmark.
FAU - Helix-Nielsen, Claus
AU  - Helix-Nielsen C
AD  - Department of Environmental Engineering, Technical University of Denmark, 
      Bygningstorvet 115, 2800 Kongens Lyngby, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210203
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
SB  - IM
EDAT- 2021/02/04 06:00
MHDA- 2021/02/04 06:01
CRDT- 2021/02/03 17:10
PHST- 2021/02/04 06:00 [pubmed]
PHST- 2021/02/04 06:01 [medline]
PHST- 2021/02/03 17:10 [entrez]
AID - 10.1021/acs.langmuir.0c03044 [doi]
PST - ppublish
SO  - Langmuir. 2021 Feb 16;37(6):2079-2090. doi: 10.1021/acs.langmuir.0c03044. Epub 
      2021 Feb 3.