PMID- 33535619
OWN - NLM
STAT- MEDLINE
DCOM- 20210913
LR  - 20240330
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 3
DP  - 2021 Feb 1
TI  - Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under 
      Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations.
LID - 10.3390/ijms22031453 [doi]
LID - 1453
AB  - Environmental factors such as maternal high-fat diet (HFD) intake can increase 
      the risk of age-related cognitive decline in adult offspring. Epigenetic 
      mechanisms are a possible link between diet effect and neurodegeneration across 
      generations. Here, we found a significant decrease in triglyceride levels in a 
      high-fat diet with resveratrol (RSV) HFD + RSV group and the offspring. Firstly, 
      we obtained better cognitive performance in HFD+RSV groups and their offspring. 
      Molecularly, a significant increase in DNA methylation (5-mC) levels, as well as 
      increased gene expression of DNA methyltransferase 1 (Dnmt1) and Dnmt3a in HFD + 
      RSV F1 group, were found. Furthermore, a significant increase of 
      N(6)-Methyladenosine methylation (m(6)A) levels in HFD+RSV F1, as well as changes 
      in gene expression of its enzymes Methyltransferase like 3 (Mettl3) and FTO 
      alpha-ketoglutarate dependent dioxygenase (Fto) were found. Moreover, we found a 
      decrease in gene expression levels of pro-inflammatory markers such as 
      Interleukin 1beta (Il1-beta), Interleukin 6 (Il-6), Tumor necrosis factor-alpha (Tnf-alpha), 
      C-X-C motif chemokine ligand 10 (Cxcl-10), the pro-inflammatory factors monocyte 
      chemoattractant protein 1 (Mcp-1) and Tumor growth factor-beta1 (Tgf-beta1) in HFD+RSV 
      and HFD+RSV F1 groups. Moreover, there was increased gene expression of 
      neurotrophins such as Neural growth factor (Ngf), Neurotrophin-3 (Nt3), and its 
      receptors Tropomyosin receptor kinase TrkA and TrkB. Likewise, an increase in 
      protein levels of brain-derived neurotrophic factor (BDNF) and phospho-protein 
      kinase B (p-Akt) in HFD+RSV F1 was found. These results suggest that maternal RSV 
      supplementation under HFD intake prevents cognitive decline in 
      senescence-accelerated mice prone 8 (SAMP8) adult offspring, promoting a 
      reduction in triglycerides and leptin plasma levels, changes in the 
      pro-inflammatory profile, and restoring the epigenetic landscape as well as 
      synaptic plasticity.
FAU - Izquierdo, Vanesa
AU  - Izquierdo V
AD  - Department of Pharmacology and Therapeutic Chemistry, Institut de 
      Neurociencies-Universitat de Barcelona, Avda. Joan XXIII, 27., 08028 Barcelona, 
      Spain.
FAU - Palomera-Avalos, Veronica
AU  - Palomera-Avalos V
AD  - Department of Cellular and Molecular Biology, University Center of Biological and 
      Agricultural Sciences, University of Guadalajara, km 15.5 Guadalajara-Nogales 
      Highway, Zapopan 45110, Jalisco, Mexico.
FAU - Pallas, Merce
AU  - Pallas M
AUID- ORCID: 0000-0003-3095-4254
AD  - Department of Pharmacology and Therapeutic Chemistry, Institut de 
      Neurociencies-Universitat de Barcelona, Avda. Joan XXIII, 27., 08028 Barcelona, 
      Spain.
FAU - Grinan-Ferre, Christian
AU  - Grinan-Ferre C
AUID- ORCID: 0000-0002-5424-9130
AD  - Department of Pharmacology and Therapeutic Chemistry, Institut de 
      Neurociencies-Universitat de Barcelona, Avda. Joan XXIII, 27., 08028 Barcelona, 
      Spain.
LA  - eng
GR  - 2017SGR106/Agaur/
PT  - Journal Article
DEP - 20210201
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Leptin)
RN  - 0 (Triglycerides)
RN  - CLE6G00625 (N-methyladenosine)
RN  - K72T3FS567 (Adenosine)
RN  - Q369O8926L (Resveratrol)
SB  - IM
EIN - Int J Mol Sci. 2021 Aug 25;22(17):. PMID: 34502568
MH  - Adenosine/analogs & derivatives/chemistry
MH  - Animals
MH  - Body Weight
MH  - Brain/physiology
MH  - Cognition
MH  - DNA Methylation
MH  - *Diet, High-Fat
MH  - *Dietary Supplements
MH  - *Epigenesis, Genetic
MH  - Epigenomics
MH  - Female
MH  - Inflammation
MH  - Leptin/blood
MH  - Male
MH  - *Maternal Exposure
MH  - Maze Learning
MH  - Methylation
MH  - Mice
MH  - Neurodegenerative Diseases
MH  - Neuronal Plasticity
MH  - Obesity/metabolism
MH  - Pregnancy
MH  - Pregnancy, Animal
MH  - *Prenatal Exposure Delayed Effects
MH  - Resveratrol/*pharmacology
MH  - Triglycerides/blood/metabolism
PMC - PMC7867164
OTO - NOTNLM
OT  - -Methyladenosine methylation
OT  - /sup&gt
OT  - 6&lt
OT  - N&lt
OT  - SAMP8
OT  - aging
OT  - cognitive decline
OT  - epigenetics
OT  - high-fat diet
OT  - multigenerational inheritance
OT  - resveratrol
OT  - sup&gt
COIS- The authors of this manuscript have no conflict of interest to declare.
EDAT- 2021/02/05 06:00
MHDA- 2021/09/14 06:00
PMCR- 2021/02/01
CRDT- 2021/02/04 01:01
PHST- 2020/12/04 00:00 [received]
PHST- 2021/01/20 00:00 [revised]
PHST- 2021/01/27 00:00 [accepted]
PHST- 2021/02/04 01:01 [entrez]
PHST- 2021/02/05 06:00 [pubmed]
PHST- 2021/09/14 06:00 [medline]
PHST- 2021/02/01 00:00 [pmc-release]
AID - ijms22031453 [pii]
AID - ijms-22-01453 [pii]
AID - 10.3390/ijms22031453 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Feb 1;22(3):1453. doi: 10.3390/ijms22031453.