PMID- 33536424
OWN - NLM
STAT- MEDLINE
DCOM- 20210222
LR  - 20221207
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 12
IP  - 1
DP  - 2021 Feb 3
TI  - Identification of 38 novel loci for systemic lupus erythematosus and genetic 
      heterogeneity between ancestral groups.
PG  - 772
LID - 10.1038/s41467-021-21049-y [doi]
LID - 772
AB  - Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high 
      heritability, shows differences in prevalence, severity and age of onset among 
      different ancestral groups. Previous genetic studies have focused more on 
      European populations, which appear to be the least affected. Consequently, the 
      genetic variations that underlie the commonalities, differences and treatment 
      options in SLE among ancestral groups have not been well elucidated. To address 
      this, we undertake a genome-wide association study, increasing the sample size of 
      Chinese populations to the level of existing European studies. Thirty-eight novel 
      SLE-associated loci and incomplete sharing of genetic architecture are 
      identified. In addition to the human leukocyte antigen (HLA) region, nine disease 
      loci show clear ancestral differences and implicate antibody production as a 
      potential mechanism for differences in disease manifestation. Polygenic risk 
      scores perform significantly better when trained on ancestry-matched data sets. 
      These analyses help to reveal the genetic basis for disparities in SLE among 
      ancestral groups.
FAU - Wang, Yong-Fei
AU  - Wang YF
AUID- ORCID: 0000-0002-1260-6291
AD  - Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, 
      Hong Kong, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong 
      Provincial Key Laboratory of Research in Structural Birth Defect Disease, 
      Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Lin, Zhiming
AU  - Lin Z
AUID- ORCID: 0000-0002-9341-4303
AD  - Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen 
      University, Guangzhou, China.
FAU - Zhang, Huoru
AU  - Zhang H
AD  - Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, 
      Hong Kong, China.
FAU - Wang, Ting-You
AU  - Wang TY
AD  - Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, 
      Hong Kong, China.
AD  - The Hormel Institute, University of Minnesota, Austin, USA.
FAU - Cao, Yujie
AU  - Cao Y
AD  - Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, 
      Hong Kong, China.
FAU - Morris, David L
AU  - Morris DL
AUID- ORCID: 0000-0002-1754-8932
AD  - Division of Genetics and Molecular Medicine, King's College London, London, UK.
FAU - Sheng, Yujun
AU  - Sheng Y
AD  - Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, China.
FAU - Yin, Xianyong
AU  - Yin X
AUID- ORCID: 0000-0001-6454-2384
AD  - Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, China.
FAU - Zhong, Shi-Long
AU  - Zhong SL
AD  - Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, 
      Guangdong Provincial People's Hospital, Guangzhou, China.
FAU - Gu, Xiaoqiong
AU  - Gu X
AD  - Department of Clinical Biological Resource Bank, Guangzhou Institute of 
      Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou, China.
FAU - Lei, Yao
AU  - Lei Y
AD  - Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, 
      Hong Kong, China.
FAU - He, Jing
AU  - He J
AD  - Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong 
      Provincial Key Laboratory of Research in Structural Birth Defect Disease, 
      Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Wu, Qi
AU  - Wu Q
AD  - Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong 
      Provincial Key Laboratory of Research in Structural Birth Defect Disease, 
      Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 
      Guangzhou, China.
FAU - Shen, Jiangshan Jane
AU  - Shen JJ
AD  - Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, 
      Hong Kong, China.
FAU - Yang, Jing
AU  - Yang J
AD  - Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, 
      Hong Kong, China.
FAU - Lam, Tai-Hing
AU  - Lam TH
AD  - School of Public Health, The University of Hong Kong, Hong Kong, China.
FAU - Lin, Jia-Huang
AU  - Lin JH
AD  - School of Public Health, The University of Hong Kong, Hong Kong, China.
FAU - Mai, Zhi-Ming
AU  - Mai ZM
AUID- ORCID: 0000-0001-9772-0669
AD  - School of Public Health, The University of Hong Kong, Hong Kong, China.
AD  - Radiation Epidemiology Branch, Division of Epidemiology and Genetics, National 
      Cancer Institute, National Institutes of Health, Bethesda, USA.
FAU - Guo, Mengbiao
AU  - Guo M
AUID- ORCID: 0000-0002-1056-9837
AD  - Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, 
      Hong Kong, China.
FAU - Tang, Yuanjia
AU  - Tang Y
AD  - Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Chen, Yanhui
AU  - Chen Y
AD  - Department of Pediatrics, Union Hospital Affiliated to Fujian Medical University, 
      Fuzhou, China.
FAU - Song, Qin
AU  - Song Q
AD  - Department of Rheumatology, Affiliated Hospital of Jining Medical University, 
      Jining, China.
FAU - Ban, Bo
AU  - Ban B
AD  - Department of Endocrinology, Affiliated Hospital of Jining Medical University, 
      Jining, China.
FAU - Mok, Chi Chiu
AU  - Mok CC
AD  - Department of Medicine, Tuen Mun Hospital, Hong Kong, China.
FAU - Cui, Yong
AU  - Cui Y
AD  - Department of Dermatology, China-Japan Friendship Hospital, Chaoyang, China.
FAU - Lu, Liangjing
AU  - Lu L
AD  - Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Shen, Nan
AU  - Shen N
AUID- ORCID: 0000-0002-5875-4417
AD  - Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Sham, Pak C
AU  - Sham PC
AUID- ORCID: 0000-0002-2533-7270
AD  - Department of Psychiatry, The University of Hong Kong, Hong Kong, China.
FAU - Lau, Chak Sing
AU  - Lau CS
AUID- ORCID: 0000-0001-6698-8355
AD  - Department of Medicine, The University of Hong Kong, Hong Kong, China.
FAU - Smith, David K
AU  - Smith DK
AD  - School of Public Health, The University of Hong Kong, Hong Kong, China.
FAU - Vyse, Timothy J
AU  - Vyse TJ
AUID- ORCID: 0000-0003-1123-1464
AD  - Division of Genetics and Molecular Medicine, King's College London, London, UK.
FAU - Zhang, Xuejun
AU  - Zhang X
AD  - Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, China.
FAU - Lau, Yu Lung
AU  - Lau YL
AD  - Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, 
      Hong Kong, China. lauylung@hku.hk.
FAU - Yang, Wanling
AU  - Yang W
AUID- ORCID: 0000-0003-0063-6327
AD  - Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, 
      Hong Kong, China. yangwl@hku.hk.
AD  - Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong 
      Kong, China. yangwl@hku.hk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210203
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
SB  - IM
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - *Genetic Heterogeneity
MH  - Genetic Predisposition to Disease/ethnology/*genetics
MH  - Genome-Wide Association Study/*methods
MH  - Genotype
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Lupus Erythematosus, Systemic/ethnology/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - White People/genetics
PMC - PMC7858632
COIS- The authors declare no competing interests.
EDAT- 2021/02/05 06:00
MHDA- 2021/02/23 06:00
PMCR- 2021/02/03
CRDT- 2021/02/04 05:43
PHST- 2020/04/26 00:00 [received]
PHST- 2021/01/11 00:00 [accepted]
PHST- 2021/02/04 05:43 [entrez]
PHST- 2021/02/05 06:00 [pubmed]
PHST- 2021/02/23 06:00 [medline]
PHST- 2021/02/03 00:00 [pmc-release]
AID - 10.1038/s41467-021-21049-y [pii]
AID - 21049 [pii]
AID - 10.1038/s41467-021-21049-y [doi]
PST - epublish
SO  - Nat Commun. 2021 Feb 3;12(1):772. doi: 10.1038/s41467-021-21049-y.