PMID- 33536518
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20211115
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Feb 3
TI  - Human leukocyte antigen B*0702 is protective against ocular Stevens-Johnson 
      syndrome/toxic epidermal necrolysis in the UK population.
PG  - 2928
LID - 10.1038/s41598-021-82400-3 [doi]
LID - 2928
AB  - Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) are part of a 
      disease continuum of vesiculobullous mucocutaneous reactions affecting the skin 
      and mucous membranes including the ocular surface. Manifestations of disease 
      range from mild dry eye to progressive conjunctival cicatrisation, limbal 
      epithelial stem cell failure and corneal blindness. In Far Eastern and South East 
      Asian populations where SJS/TEN is prevalent, numerous human leukocyte antigen 
      (HLA) gene variants at the A, B and C loci have been identified as risk factors 
      for developing SJS/TEN with severe ocular complications (SOC). By contrast, the 
      incidence of SJS/TEN with SOC in European countries is relatively low. To date, 
      ocular SJS/TEN risk altering alleles have not been widely investigated in 
      European populations. In this study, we analysed the association of HLA -A, -B 
      and -C alleles with SJS/TEN in 33 patients residing in the UK with age matched 
      controls. The data showed statistically significant novel negative allele 
      association with HLA-B*0702 and a trend with HLA-C*0702 in the patient group, 
      indicating these alleles are protective. Further characterisation of protective 
      and risk alleles in other ethnic groups is required to fully elucidate the 
      putative role of these alleles in the susceptibility of SJS/TEN with or without 
      severe ocular complications in patients in the UK.
FAU - Butt, Gibran F
AU  - Butt GF
AD  - Academic Unit of Ophthalmology, Birmingham and Midland Eye Centre, Institute of 
      Inflammation and Ageing, College of Medical and Dental Sciences, University of 
      Birmingham, Dudley Road, Birmingham, B18 7QU, UK.
AD  - Birmingham & Midland Eye Centre, Sandwell and West Birmingham Hospitals NHS 
      Trust, Birmingham, UK.
FAU - Hassan, Ali
AU  - Hassan A
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
AD  - Institute of Ophthalmology, University College London, London, UK.
FAU - Wallace, Graham R
AU  - Wallace GR
AD  - Academic Unit of Ophthalmology, Birmingham and Midland Eye Centre, Institute of 
      Inflammation and Ageing, College of Medical and Dental Sciences, University of 
      Birmingham, Dudley Road, Birmingham, B18 7QU, UK.
AD  - Birmingham & Midland Eye Centre, Sandwell and West Birmingham Hospitals NHS 
      Trust, Birmingham, UK.
FAU - Kinoshita, Shigeru
AU  - Kinoshita S
AD  - Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto 
      Prefectural University of Medicine, Kyoto, Japan.
FAU - Ahmad, Sajjad
AU  - Ahmad S
AD  - Moorfields Eye Hospital NHS Foundation Trust, London, UK.
AD  - Institute of Ophthalmology, University College London, London, UK.
AD  - St Paul's Eye Unit, The Royal Liverpool and Broadgreen University Hospitals NHS 
      Trust, Liverpool, UK.
FAU - Ueta, Mayumi
AU  - Ueta M
AD  - Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto 
      Prefectural University of Medicine, Kyoto, Japan.
FAU - Rauz, Saaeha
AU  - Rauz S
AD  - Academic Unit of Ophthalmology, Birmingham and Midland Eye Centre, Institute of 
      Inflammation and Ageing, College of Medical and Dental Sciences, University of 
      Birmingham, Dudley Road, Birmingham, B18 7QU, UK. s.rauz@bham.ac.uk.
AD  - Birmingham & Midland Eye Centre, Sandwell and West Birmingham Hospitals NHS 
      Trust, Birmingham, UK. s.rauz@bham.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210203
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (HLA-B*07:02 antigen)
RN  - 0 (HLA-B7 Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Child
MH  - Child, Preschool
MH  - Eye Diseases/epidemiology/*genetics/immunology
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-B7 Antigen/*genetics/immunology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Protective Factors
MH  - Stevens-Johnson Syndrome/epidemiology/*genetics/immunology
MH  - United Kingdom/epidemiology
MH  - Young Adult
PMC - PMC7859395
COIS- The authors declare no competing interests.
EDAT- 2021/02/05 06:00
MHDA- 2021/11/16 06:00
PMCR- 2021/02/03
CRDT- 2021/02/04 05:45
PHST- 2020/07/25 00:00 [received]
PHST- 2020/12/15 00:00 [accepted]
PHST- 2021/02/04 05:45 [entrez]
PHST- 2021/02/05 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/02/03 00:00 [pmc-release]
AID - 10.1038/s41598-021-82400-3 [pii]
AID - 82400 [pii]
AID - 10.1038/s41598-021-82400-3 [doi]
PST - epublish
SO  - Sci Rep. 2021 Feb 3;11(1):2928. doi: 10.1038/s41598-021-82400-3.