PMID- 33536771
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220420
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 14
DP  - 2021
TI  - Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 
      Diabetes Patients.
PG  - 379-385
LID - 10.2147/DMSO.S290072 [doi]
AB  - OBJECTIVE: To investigate the plasma alarin level in newly diagnosed obese type 2 
      diabetes mellitus (T2DM) and its correlation with glucose and lipid metabolism 
      and insulin resistance. METHODS: From October 2018 to June 2020, 239 newly 
      diagnosed T2DM patients were collected. According to obesity, patients were 
      divided into T2DM obese group (n=135) and T2DM non-obese group (n =104). Gender, 
      age, body mass index (BMI), blood lipids, blood glucose, glycosylated hemoglobin 
      A1c (HbA1c), fasting insulin (FINS), plasma alarin concentration, homeostasis 
      model assessment for insulin resistance (HOMA-IR), homeostasis model assessment 
      for beta-cell function (HOMA-beta) and other clinical data were collected and analyzed. 
      RESULTS: BMI, triacylglycerol (TG), total cholesterol (TC), low-density 
      lipoprotein-cholesterol (LDL-C), fasting blood glucose (FPG), HbA1c, FINS, plasma 
      alarin levels and HOMA-IR in the control group, T2DM non-obese group and T2DM 
      obese group increased sequentially, and high-density lipoprotein-cholesterol 
      (HDL-L) and HOMA-beta decreased sequentially (P<0.05). Correlation analysis results 
      showed that plasma alarin levels in T2DM patients were positively correlated with 
      waistline, BMI, TC, LDL-C, FPG, HbA1c, FINS and HOMA-IR (P<0.05), and negatively 
      correlated with HDL-C and HOMA-beta (P <0.05), and the correlation coefficient of 
      T2DM obese group was significantly higher than that of T2DM non-obese group 
      (P<0.05). Multiple linear stepwise regression analysis showed that BMI, FPG, 
      HbA1c, HOMA-beta, and HOMA-IR were independent factors related to plasma alarin 
      levels in T2DM non-obese and T2DM obese patients, and the correlation coefficient 
      of the T2DM obese group was significantly higher than that of the T2DM non-obese 
      group (P <0.05). CONCLUSION: Plasma alarin levels increase in newly diagnosed 
      T2DM and obese T2DM patients, which are affected by TC, BMI, FPG, HbA1c, HOMA-beta 
      and HOMA-IR, and may be involved in development of T2DM.
CI  - (c) 2021 Zhou et al.
FAU - Zhou, Xin
AU  - Zhou X
AD  - Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, 
      Chongqing 400000, People's Republic of China.
FAU - Luo, Mei
AU  - Luo M
AD  - Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, 
      Chongqing 400000, People's Republic of China.
FAU - Zhou, Sha
AU  - Zhou S
AD  - Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, 
      Chongqing 400000, People's Republic of China.
FAU - Cheng, Zhiling
AU  - Cheng Z
AD  - Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, 
      Chongqing 400000, People's Republic of China.
FAU - Chen, Zhongpei
AU  - Chen Z
AD  - Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, 
      Chongqing 400000, People's Republic of China.
FAU - Yu, Xiaoxia
AU  - Yu X
AD  - Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, 
      Chongqing 400000, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210127
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC7850453
OTO - NOTNLM
OT  - blood lipids
OT  - blood sugar
OT  - insulin
OT  - insulin resistance
OT  - obesity
OT  - plasma alarin level
OT  - type 2 diabetes mellitus
COIS- The authors declare that they have no conflicts of interest for this work.
EDAT- 2021/02/05 06:00
MHDA- 2021/02/05 06:01
PMCR- 2021/01/27
CRDT- 2021/02/04 05:50
PHST- 2020/11/02 00:00 [received]
PHST- 2020/12/22 00:00 [accepted]
PHST- 2021/02/04 05:50 [entrez]
PHST- 2021/02/05 06:00 [pubmed]
PHST- 2021/02/05 06:01 [medline]
PHST- 2021/01/27 00:00 [pmc-release]
AID - 290072 [pii]
AID - 10.2147/DMSO.S290072 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2021 Jan 27;14:379-385. doi: 10.2147/DMSO.S290072. 
      eCollection 2021.