PMID- 33536867
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210206
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 14
DP  - 2020
TI  - White Matter Atrophy in Type 2 Diabetes Mellitus Patients With Mild Cognitive 
      Impairment.
PG  - 602501
LID - 10.3389/fnins.2020.602501 [doi]
LID - 602501
AB  - Type 2 diabetes mellitus (T2DM) patients are highly susceptible to developing 
      dementia, especially for those with mild cognitive impairment (MCI), but its 
      underlying cause is still unclear. In this study, we performed a battery of 
      neuropsychological tests and high-resolution sagittal T1-weighted structural 
      imaging to explore how T2DM affects white matter volume (WMV) and cognition in 30 
      T2DM-MCI patients, 30 T2DM with normal cognition (T2DM-NC) patients, and 30 age-, 
      sex-, and education-matched healthy control (HC) individuals. The WMV of the 
      whole brain was obtained with automated segmentation methods. Correlations 
      between the WMV of each brain region and neuropsychological tests were analyzed 
      in the T2DM patients. The T2DM-NC patients and HC individuals did not reveal any 
      significant differences in WMV. Compared with the T2DM-NC group, the T2DM-MCI 
      group showed statistically significant reduction in the WMV of seven brain 
      regions, mainly located in the frontotemporal lobe and limbic system, five of 
      which significantly correlated with Montreal Cognitive Assessment (MoCA) scores. 
      Subsequently, we evaluated the discriminative ability of these five regions for 
      MCI in T2DM patients. The WMV of four regions, including left posterior 
      cingulate, precuneus, insula, and right rostral middle frontal gyrus had high 
      diagnostic value for MCI detection in T2DM patients (AUC > 0.7). Among these four 
      regions, left precuneus WMV presented the best diagnostic value (AUC: 0.736; 
      sensitivity: 70.00%; specificity: 73.33%; Youden index: 0.4333), but with no 
      significant difference relative to the minimum AUC. In conclusion, T2DM could 
      give rise to the white matter atrophy of several brain regions. Each WMV of left 
      posterior cingulate, precuneus, insula, and right rostral middle frontal gyrus 
      could be an independent imaging biomarker to detect cognitive impairment at the 
      early stage in T2DM patients and play an important role in its pathophysiological 
      mechanism.
CI  - Copyright (c) 2021 Li, Jin, Liu, Li, Zuo, Tong, Zhang, Zhang, Guo, Lai, Sun, Wang, 
      Xiong and Chen.
FAU - Li, Chang
AU  - Li C
AD  - Department of Radiology, Daping Hospital, Army Medical University, Chongqing, 
      China.
AD  - Department of Radiology, Southwest Hospital, Army Medical University, Chongqing, 
      China.
FAU - Jin, Rongbing
AU  - Jin R
AD  - Department of Nuclear Medicine, Daping Hospital, Army Medical University, 
      Chongqing, China.
AD  - Chongqing Clinical Research Center for Imaging and Nuclear Medicine, Chongqing, 
      China.
FAU - Liu, Kaijun
AU  - Liu K
AD  - Department of Gastroenterology, Daping Hospital, Army Medical University, 
      Chongqing, China.
FAU - Li, Yang
AU  - Li Y
AD  - Department of Radiology, Daping Hospital, Army Medical University, Chongqing, 
      China.
FAU - Zuo, Zhiwei
AU  - Zuo Z
AD  - Department of Radiology, General Hospital of Western Theater Command, Chengdu, 
      China.
FAU - Tong, Haipeng
AU  - Tong H
AD  - Department of Radiology, Daping Hospital, Army Medical University, Chongqing, 
      China.
AD  - Chongqing Clinical Research Center for Imaging and Nuclear Medicine, Chongqing, 
      China.
FAU - Zhang, Jingna
AU  - Zhang J
AD  - Department of Medical Imaging, College of Biomedical Engineering, Army Medical 
      University, Chongqing, China.
FAU - Zhang, Junfeng
AU  - Zhang J
AD  - Department of Radiology, Daping Hospital, Army Medical University, Chongqing, 
      China.
AD  - Chongqing Clinical Research Center for Imaging and Nuclear Medicine, Chongqing, 
      China.
FAU - Guo, Yu
AU  - Guo Y
AD  - Department of Radiology, Daping Hospital, Army Medical University, Chongqing, 
      China.
FAU - Lai, Yuqi
AU  - Lai Y
AD  - School of Foreign Languages and Cultures, Chongqing University, Chongqing, China.
FAU - Sun, Jinju
AU  - Sun J
AD  - Department of Nuclear Medicine, Daping Hospital, Army Medical University, 
      Chongqing, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Radiology, Southwest Hospital, Army Medical University, Chongqing, 
      China.
FAU - Xiong, Kunlin
AU  - Xiong K
AD  - Department of Radiology, Daping Hospital, Army Medical University, Chongqing, 
      China.
AD  - Chongqing Clinical Research Center for Imaging and Nuclear Medicine, Chongqing, 
      China.
FAU - Chen, Xiao
AU  - Chen X
AD  - Department of Nuclear Medicine, Daping Hospital, Army Medical University, 
      Chongqing, China.
AD  - Chongqing Clinical Research Center for Imaging and Nuclear Medicine, Chongqing, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20210118
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC7848149
OTO - NOTNLM
OT  - biomarker
OT  - magnetic resonance imaging
OT  - mild cognitive impairment
OT  - type 2 diabetes mellitus
OT  - white matter volume
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The reviewer XY declared a past co-authorship with the 
      authors CL, ZZ, and JW to the handling editor.
EDAT- 2021/02/05 06:00
MHDA- 2021/02/05 06:01
PMCR- 2020/01/01
CRDT- 2021/02/04 05:50
PHST- 2020/09/03 00:00 [received]
PHST- 2020/12/21 00:00 [accepted]
PHST- 2021/02/04 05:50 [entrez]
PHST- 2021/02/05 06:00 [pubmed]
PHST- 2021/02/05 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2020.602501 [doi]
PST - epublish
SO  - Front Neurosci. 2021 Jan 18;14:602501. doi: 10.3389/fnins.2020.602501. 
      eCollection 2020.