PMID- 33537005
OWN - NLM
STAT- MEDLINE
DCOM- 20210525
LR  - 20220416
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 11
DP  - 2020
TI  - Hypogonadism, Type-2 Diabetes Mellitus, and Bone Health: A Narrative Review.
PG  - 607240
LID - 10.3389/fendo.2020.607240 [doi]
LID - 607240
AB  - One of the complications from chronic hyperglycemia and insulin resistance due to 
      type 2 diabetes mellitus (T2DM) on the hypothalamic-pituitary-gonadal axis in men 
      is the high prevalence of hypogonadotropic hypogonadism (HH). Both T2DM and 
      hypogonadism are associated with impaired bone health and increased fracture risk 
      but whether the combination results in even worse bone disease than either one 
      alone is not well-studied. It is possible that having both conditions predisposes 
      men to an even greater risk for fracture than either one alone. Given the common 
      occurrence of HH or hypogonadism in general in T2DM, a significant number of men 
      could be at risk. To date, there is very little information on the bone health 
      men with both hypogonadism and T2DM. Insulin resistance, which is the primary 
      defect in T2DM, is associated with low testosterone (T) levels in men and may 
      play a role in the bidirectional relationship between these two conditions, which 
      together may portend a worse outcome for bone. The present manuscript aims to 
      review the available evidences on the effect of the combination of hypogonadism 
      and T2DM on bone health and metabolic profile, highlights the possible metabolic 
      role of the skeleton, and examines the pathways involved in the interplay between 
      bone, insulin resistance, and gonadal steroids.
CI  - Copyright (c) 2021 Russo, Chen and Armamento-Villareal.
FAU - Russo, Vittoria
AU  - Russo V
AD  - Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, 
      Baylor College of Medicine, Houston, TX, United States.
AD  - Department of Medicine, Michael E. DeBakey VA Medical Center, Houston, TX, United 
      States.
FAU - Chen, Rui
AU  - Chen R
AD  - Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, 
      Baylor College of Medicine, Houston, TX, United States.
AD  - Department of Medicine, Michael E. DeBakey VA Medical Center, Houston, TX, United 
      States.
FAU - Armamento-Villareal, Reina
AU  - Armamento-Villareal R
AD  - Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, 
      Baylor College of Medicine, Houston, TX, United States.
AD  - Department of Medicine, Michael E. DeBakey VA Medical Center, Houston, TX, United 
      States.
LA  - eng
GR  - I01 CX001665/CX/CSRD VA/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210118
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Gonadotropins)
SB  - IM
MH  - Adult
MH  - Bone Density
MH  - Bone and Bones/*pathology
MH  - Diabetes Mellitus, Type 2/*complications/pathology
MH  - Gonadotropins/deficiency
MH  - Health Status
MH  - Humans
MH  - Hypogonadism/*complications/pathology
MH  - Insulin Resistance
MH  - Male
MH  - Osteoporosis/etiology/pathology
PMC - PMC7848021
OTO - NOTNLM
OT  - hypogonadotropic hypogonadism
OT  - hypothalamic-pituitary-gonadal axis
OT  - insulin resistance
OT  - osteoporosis
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/02/05 06:00
MHDA- 2021/05/26 06:00
PMCR- 2020/01/01
CRDT- 2021/02/04 05:51
PHST- 2020/09/16 00:00 [received]
PHST- 2020/11/30 00:00 [accepted]
PHST- 2021/02/04 05:51 [entrez]
PHST- 2021/02/05 06:00 [pubmed]
PHST- 2021/05/26 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2020.607240 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2021 Jan 18;11:607240. doi: 
      10.3389/fendo.2020.607240. eCollection 2020.