PMID- 33537464
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210206
IS  - 2405-5808 (Electronic)
IS  - 2405-5808 (Linking)
VI  - 25
DP  - 2021 Mar
TI  - A high methionine and low folate diet alters glucose homeostasis and gut 
      microbiome.
PG  - 100921
LID - 10.1016/j.bbrep.2021.100921 [doi]
LID - 100921
AB  - Hyperhomocysteinemia (HHcy) is considered as a risk factor for several 
      complications, including cardiovascular and neurological disorders. A high 
      methionine low folate (HMLF) diet chronically causes HHcy by accumulating 
      homocysteine in the systemic circulation. Elevated Hcy level is also associated 
      with the incidence of diabetes mellitus. However, very few studies focus on the 
      impact of HMLF diet on glucose homeostasis, and that on gut microbiome profile. 
      HHcy was induced by feeding C57BL/6 mice a HMLF diet for 8 weeks. The HMLF diet 
      feeding resulted in a progressive body weight loss, and development of slight 
      glucose intolerance and insulin resistance in HHcy mice. Notably, the HMLF diet 
      alters the gut microbiome profile and increases the relative abundance of 
      porphyromonadaceae family of bacteria in HHcy mice. These findings provide new 
      insights into the roles of dysregulated glucose homeostasis and gut flora in the 
      pathogenesis of HHcy-related complications.
CI  - (c) 2021 Published by Elsevier B.V.
FAU - Cheng, Chak Kwong
AU  - Cheng CK
AD  - School of Biomedical Sciences and Li Ka Shing Institute of Health Science, The 
      Chinese University of Hong Kong, Hong Kong SAR, China.
AD  - Heart and Vascular Institute and Shenzhen Research Institute, The Chinese 
      University of Hong Kong, Hong Kong SAR, China.
FAU - Wang, Chenguang
AU  - Wang C
AD  - School of Biomedical Sciences and Li Ka Shing Institute of Health Science, The 
      Chinese University of Hong Kong, Hong Kong SAR, China.
AD  - Heart and Vascular Institute and Shenzhen Research Institute, The Chinese 
      University of Hong Kong, Hong Kong SAR, China.
AD  - Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 
      China.
FAU - Shang, Wenbin
AU  - Shang W
AD  - School of Biomedical Sciences and Li Ka Shing Institute of Health Science, The 
      Chinese University of Hong Kong, Hong Kong SAR, China.
AD  - Heart and Vascular Institute and Shenzhen Research Institute, The Chinese 
      University of Hong Kong, Hong Kong SAR, China.
FAU - Lau, Chi Wai
AU  - Lau CW
AD  - School of Biomedical Sciences and Li Ka Shing Institute of Health Science, The 
      Chinese University of Hong Kong, Hong Kong SAR, China.
AD  - Heart and Vascular Institute and Shenzhen Research Institute, The Chinese 
      University of Hong Kong, Hong Kong SAR, China.
FAU - Luo, Jiang-Yun
AU  - Luo JY
AD  - School of Biomedical Sciences and Li Ka Shing Institute of Health Science, The 
      Chinese University of Hong Kong, Hong Kong SAR, China.
AD  - Heart and Vascular Institute and Shenzhen Research Institute, The Chinese 
      University of Hong Kong, Hong Kong SAR, China.
FAU - Wang, Li
AU  - Wang L
AD  - School of Biomedical Sciences and Li Ka Shing Institute of Health Science, The 
      Chinese University of Hong Kong, Hong Kong SAR, China.
AD  - Heart and Vascular Institute and Shenzhen Research Institute, The Chinese 
      University of Hong Kong, Hong Kong SAR, China.
FAU - Huang, Yu
AU  - Huang Y
AD  - School of Biomedical Sciences and Li Ka Shing Institute of Health Science, The 
      Chinese University of Hong Kong, Hong Kong SAR, China.
AD  - Heart and Vascular Institute and Shenzhen Research Institute, The Chinese 
      University of Hong Kong, Hong Kong SAR, China.
LA  - eng
PT  - Journal Article
DEP - 20210122
PL  - Netherlands
TA  - Biochem Biophys Rep
JT  - Biochemistry and biophysics reports
JID - 101660999
PMC - PMC7838713
OTO - NOTNLM
OT  - 16S rRNA sequencing
OT  - Glucose homeostasis
OT  - Gut microbiome
OT  - HDL, high-density lipoprotein
OT  - HHcy, hyperhomocysteinemia
OT  - HMLF diet
OT  - HMLF, high methionine low folate
OT  - Hcy, homocysteine
OT  - Hyperhomocysteinemia
OT  - LEfSe, linear discriminant analysis effect size
OT  - NAFLD, non-alcoholic fatty liver disease
OT  - NMDS, non-metric multi-dimensional scaling
OT  - OTU, operational taxonomic unit
OT  - PCA, principal component analysis
OT  - Porphyromonadaceae
OT  - SCFA, short-chain fatty acids
OT  - TC, total cholesterol
OT  - TG, triglyceride
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2021/02/05 06:00
MHDA- 2021/02/05 06:01
PMCR- 2021/01/22
CRDT- 2021/02/04 05:52
PHST- 2020/11/10 00:00 [received]
PHST- 2021/01/10 00:00 [revised]
PHST- 2021/01/11 00:00 [accepted]
PHST- 2021/02/04 05:52 [entrez]
PHST- 2021/02/05 06:00 [pubmed]
PHST- 2021/02/05 06:01 [medline]
PHST- 2021/01/22 00:00 [pmc-release]
AID - S2405-5808(21)00015-7 [pii]
AID - 100921 [pii]
AID - 10.1016/j.bbrep.2021.100921 [doi]
PST - epublish
SO  - Biochem Biophys Rep. 2021 Jan 22;25:100921. doi: 10.1016/j.bbrep.2021.100921. 
      eCollection 2021 Mar.