PMID- 33537891
OWN - NLM
STAT- MEDLINE
DCOM- 20211117
LR  - 20211117
IS  - 1437-2320 (Electronic)
IS  - 0344-5607 (Linking)
VI  - 44
IP  - 6
DP  - 2021 Dec
TI  - Mucosal thickening of the maxillary sinus is frequently associated with diffuse 
      glioma patients and correlates with poor survival prognosis of GBM patients: 
      comparative analysis to meningioma patients.
PG  - 3249-3258
LID - 10.1007/s10143-021-01490-9 [doi]
AB  - Glioma patients were frequently associated with mucosal thickening of the 
      maxillary sinus (MTMS), which reflects mucosal inflammation. We suspected that 
      MTMS is associated with impaired mucosal immune response and correlated with 
      dysfunction in the anti-tumor immune response in diffuse glioma patients. 
      Therefore, the aim of this study was to determine whether the occurrence of 
      diffuse glioma is correlated with MTMS compared to meningioma and control groups. 
      Furthermore, we investigated whether MTMS is associated with overall survival 
      (OS) in glioblastoma (GBM) patients. This study included 343 patients with newly 
      diagnosed diffuse gliomas and 218 patients with meningioma treated at our 
      institution between 2015 and 2018. As control, 201 patients with headache who did 
      not have an intracranial organic lesion were included. Using three-axis MR 
      images, we evaluated the incidence of MTMS in all patients. Additionally, we 
      investigated the relationship between MTMS and OS. The incidence of MTMS in 
      patients with diffuse glioma was significantly higher than that in the meningioma 
      (p < .0001) and control groups (p < .0001). In 128 patients with GBM, MTMS status 
      correlated significantly with OS (p = .0064). We revealed that the incidence of 
      MTMS is significantly associated with patients with diffuse glioma. This suggests 
      that MTMS is indirectly involved in the occurrence of diffuse gliomas. 
      Furthermore, the presence of MTMS correlated significantly with shorter OS in GBM 
      patients, indicating that MTMS is involved in suppression of anti-tumor immune 
      response. Preoperative recognition of MTMS might be useful for improving the 
      clinical management of GBM patients.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part 
      of Springer Nature.
FAU - Saito, Taiichi
AU  - Saito T
AUID- ORCID: 0000-0002-5016-9619
AD  - Department of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho, 
      Shinjuku-ku, Tokyo, 162-8666, Japan. taiichis@gmail.com.
AD  - Faculty of Advanced Techno-Surgery, Tokyo Women's Medical University, Tokyo, 
      Japan. taiichis@gmail.com.
FAU - Muragaki, Yoshihiro
AU  - Muragaki Y
AD  - Department of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho, 
      Shinjuku-ku, Tokyo, 162-8666, Japan.
AD  - Faculty of Advanced Techno-Surgery, Tokyo Women's Medical University, Tokyo, 
      Japan.
FAU - Maruyama, Takashi
AU  - Maruyama T
AD  - Department of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho, 
      Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Abe, Kayoko
AU  - Abe K
AD  - Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical 
      University, Tokyo, Japan.
FAU - Komori, Takashi
AU  - Komori T
AD  - Department of Laboratory Medicine and Pathology (Neuropathology), Tokyo 
      Metropolitan Neurological Hospital, Tokyo, Japan.
FAU - Amano, Kosaku
AU  - Amano K
AD  - Department of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho, 
      Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Eguchi, Seiichiro
AU  - Eguchi S
AD  - Department of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho, 
      Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Nitta, Masayuki
AU  - Nitta M
AD  - Department of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho, 
      Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Tsuzuki, Shunsuke
AU  - Tsuzuki S
AD  - Department of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho, 
      Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Fukui, Atsushi
AU  - Fukui A
AD  - Department of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho, 
      Shinjuku-ku, Tokyo, 162-8666, Japan.
FAU - Kawamata, Takakazu
AU  - Kawamata T
AD  - Department of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho, 
      Shinjuku-ku, Tokyo, 162-8666, Japan.
LA  - eng
GR  - 18K09006/Japan Society for the Promotion of Science (JSPS) KAKENHI/
PT  - Journal Article
DEP - 20210203
PL  - Germany
TA  - Neurosurg Rev
JT  - Neurosurgical review
JID - 7908181
SB  - IM
MH  - *Brain Neoplasms
MH  - *Glioblastoma
MH  - *Glioma
MH  - Humans
MH  - Maxillary Sinus
MH  - *Meningeal Neoplasms
MH  - *Meningioma/surgery
MH  - Prognosis
OTO - NOTNLM
OT  - Etiology
OT  - Glioma
OT  - Maxillary sinus
OT  - Meningioma
OT  - Mucosal thickening
EDAT- 2021/02/05 06:00
MHDA- 2021/11/18 06:00
CRDT- 2021/02/04 05:55
PHST- 2020/12/03 00:00 [received]
PHST- 2021/01/26 00:00 [accepted]
PHST- 2021/01/06 00:00 [revised]
PHST- 2021/02/05 06:00 [pubmed]
PHST- 2021/11/18 06:00 [medline]
PHST- 2021/02/04 05:55 [entrez]
AID - 10.1007/s10143-021-01490-9 [pii]
AID - 10.1007/s10143-021-01490-9 [doi]
PST - ppublish
SO  - Neurosurg Rev. 2021 Dec;44(6):3249-3258. doi: 10.1007/s10143-021-01490-9. Epub 
      2021 Feb 3.