PMID- 33538508
OWN - NLM
STAT- MEDLINE
DCOM- 20210512
LR  - 20210520
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 134
IP  - 7
DP  - 2021 Feb 3
TI  - Relationship of serum vitamin D levels with diabetic microvascular complications 
      in patients with type 2 diabetes mellitus.
PG  - 814-820
LID - 10.1097/CM9.0000000000001364 [doi]
AB  - BACKGROUND: Vitamin D deficiency has been reported to be associated with diabetic 
      microvascular complications, but previous studies have only focused on the 
      relationship between vitamin D and specific complications. Therefore, we aimed to 
      explore the relationship between vitamin D level and diabetic microvascular 
      complications in general, including diabetic retinopathy (DR), diabetic 
      nephropathy (DN), and diabetic peripheral neuropathy (DPN). METHODS: This was a 
      cross-sectional study of 815 patients with type 2 diabetes mellitus (T2DM). 
      Clinical information and laboratory results were collected from the medical 
      records. The relationship between vitamin D and the three diabetic microvascular 
      complications was investigated. RESULTS: The serum 25-hydroxyvitamin D (25 [OH] 
      D) level of patients with DPN and/or DN was significantly lower than that of T2DM 
      patients without any microvascular complications (P < 0.01). Univariate analysis 
      showed that the 25 (OH) D level was related to DPN and DN, but not DR. After 
      adjustment, the 25 (OH) D level was confirmed to be an independent protective 
      factor for DPN (odds ratio [OR]: 0.968, P = 0.004]) and DN (OR: 0.962, 
      P = 0.006). The prevalence of DPN and DN increased significantly as the serum 25 
      (OH) D levels decreased. Furthermore, patients with both DPN and DN had the 
      lowest concentration of serum 25 (OH) D (P < 0.001), and the prevalence of 
      macroalbuminuria increased more abruptly than that of microalbuminuria across the 
      25 (OH) D tertiles. Among the patients with vitamin D insufficiency, those with 
      DPN presented more comorbid macroalbuminuria than those without DPN (15.32% vs. 
      4.91%; P = 0.001). CONCLUSIONS: Vitamin D deficiency is independently associated 
      with higher risk of DPN and DN, but not DR, in T2DM patients. Further, it may be 
      a potential predictor for both the occurrence and severity of DPN and DN.
CI  - Copyright (c) 2021 The Chinese Medical Association, produced by Wolters Kluwer, 
      Inc. under the CC-BY-NC-ND license.
FAU - Zhao, Wei-Jing
AU  - Zhao WJ
AD  - Department of Endocrinology and Metabolism, Shanghai Clinical Center for 
      Metabolic Diseases, Shanghai Diabetes Institute, Shanghai Key Laboratory of 
      Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, Shanghai, 200233, China.
FAU - Xia, Xin-Yi
AU  - Xia XY
AD  - Shanghai Clinical Center for Metabolic Diseases, Shanghai Key Laboratory of 
      Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University 
      Affiliated Sixth People's Hospital, Shanghai 200233, China.
FAU - Yin, Jun
AU  - Yin J
AD  - Department of Endocrinology and Metabolism, Shanghai Clinical Center for 
      Metabolic Diseases, Shanghai Diabetes Institute, Shanghai Key Laboratory of 
      Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, Shanghai, 200233, China.
AD  - Department of Endocrinology and Metabolism, Shanghai Eighth People's Hospital, 
      Shanghai 200235, China.
LA  - eng
PT  - Journal Article
DEP - 20210203
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Diabetic Nephropathies
MH  - *Diabetic Neuropathies
MH  - Humans
MH  - Risk Factors
MH  - Vitamin D
PMC - PMC8104216
COIS- None.
EDAT- 2021/02/05 06:00
MHDA- 2021/05/13 06:00
PMCR- 2021/04/05
CRDT- 2021/02/04 11:07
PHST- 2021/02/05 06:00 [pubmed]
PHST- 2021/05/13 06:00 [medline]
PHST- 2021/02/04 11:07 [entrez]
PHST- 2021/04/05 00:00 [pmc-release]
AID - 00029330-202104050-00009 [pii]
AID - CMJ-2020-2592 [pii]
AID - 10.1097/CM9.0000000000001364 [doi]
PST - epublish
SO  - Chin Med J (Engl). 2021 Feb 3;134(7):814-820. doi: 10.1097/CM9.0000000000001364.