PMID- 33539818
OWN - NLM
STAT- MEDLINE
DCOM- 20210519
LR  - 20210519
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 896
DP  - 2021 Apr 5
TI  - HDAC1 regulates the chemosensitivity of laryngeal carcinoma cells via modulation 
      of interleukin-8 expression.
PG  - 173923
LID - S0014-2999(21)00076-5 [pii]
LID - 10.1016/j.ejphar.2021.173923 [doi]
AB  - Chemotherapies such as 5-fluorouracil (5-FU) and cisplatin (CDDP) have been 
      widely used to treat laryngeal squamous cell carcinoma (LSCC), the second most 
      common head and neck squamous cell carcinoma. However, chemoresistance seriously 
      impairs chemotherapeutic efficacy. Our present study reveals that 5-FU and CDDP 
      treatment increase the expression of histone deacetylase 1 (HDAC1) in LSCC cells. 
      Consistently, increased levels of HDAC1 are observed in chemoresistant cells. 
      Knockdown of HDAC1 significantly restores the sensitivity of LSCC cells, as HDAC1 
      increases the expression of interleukin-8 (IL-8), which is essential for LSCC 
      chemoresistance. Mechanistically, HDAC1 directly initiates the transcription of 
      IL-8 though binding to its promoter. Simultaneously, si-HDAC1 increases the 
      levels of miR-93, which binds to the 3'UTR of IL-8 mRNA to trigger its 
      degradation. In summary, the HDAC1/IL-8 axis can confer chemotherapeutic 
      resistance to LSCC cells.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Ding, Sijuan
AU  - Ding S
AD  - Department of Oncology, The Central Hospital of Yongzhou, Yongzhou, 425000, 
      China. Electronic address: 874663807@qq.com.
FAU - Tang, Zhaohui
AU  - Tang Z
AD  - Department of Oncology, The Central Hospital of Yongzhou, Yongzhou, 425000, 
      China. Electronic address: drzhaohuitang@126.com.
FAU - Jiang, Yongjun
AU  - Jiang Y
AD  - Department of Oncology, The Central Hospital of Yongzhou, Yongzhou, 425000, 
      China. Electronic address: jiangyongjun@csco.org.cn.
FAU - Luo, Pengfei
AU  - Luo P
AD  - Department of Oncology, The Central Hospital of Yongzhou, Yongzhou, 425000, 
      China. Electronic address: 76756518@qq.com.
FAU - Qing, Bohua
AU  - Qing B
AD  - Department of Oncology, The Central Hospital of Yongzhou, Yongzhou, 425000, 
      China. Electronic address: 1535557236@qq.com.
FAU - Wei, Yanhong
AU  - Wei Y
AD  - Department of Oncology, The Central Hospital of Yongzhou, Yongzhou, 425000, 
      China. Electronic address: 651134792@qq.com.
FAU - Zhang, Siyuan
AU  - Zhang S
AD  - Department of Oncology, The Central Hospital of Yongzhou, Yongzhou, 425000, 
      China. Electronic address: siyuan@163.com.
FAU - Tang, Ruoting
AU  - Tang R
AD  - Department of Oncology, The Central Hospital of Yongzhou, Yongzhou, 425000, 
      China. Electronic address: 1156639421@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20210202
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Interleukin-8)
RN  - EC 3.5.1.98 (HDAC1 protein, human)
RN  - EC 3.5.1.98 (Histone Deacetylase 1)
RN  - Q20Q21Q62J (Cisplatin)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Antineoplastic Agents/*pharmacology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Cisplatin/*pharmacology
MH  - Drug Resistance, Neoplasm
MH  - Fluorouracil/*pharmacology
MH  - Gene Expression Regulation, Neoplastic
MH  - Histone Deacetylase 1/genetics/*metabolism
MH  - Humans
MH  - Interleukin-8/genetics/*metabolism
MH  - Laryngeal Neoplasms/*drug therapy/enzymology/pathology
MH  - Signal Transduction
MH  - Squamous Cell Carcinoma of Head and Neck/*drug therapy/enzymology/pathology
OTO - NOTNLM
OT  - HDAC1
OT  - IL-8
OT  - Laryngeal carcinoma
OT  - miR-93
EDAT- 2021/02/05 06:00
MHDA- 2021/05/20 06:00
CRDT- 2021/02/04 20:12
PHST- 2020/07/20 00:00 [received]
PHST- 2021/01/14 00:00 [revised]
PHST- 2021/01/29 00:00 [accepted]
PHST- 2021/02/05 06:00 [pubmed]
PHST- 2021/05/20 06:00 [medline]
PHST- 2021/02/04 20:12 [entrez]
AID - S0014-2999(21)00076-5 [pii]
AID - 10.1016/j.ejphar.2021.173923 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2021 Apr 5;896:173923. doi: 10.1016/j.ejphar.2021.173923. Epub 
      2021 Feb 2.