PMID- 33540340 OWN - NLM STAT- MEDLINE DCOM- 20211008 LR - 20211008 IS - 1532-3064 (Electronic) IS - 0954-6111 (Linking) VI - 178 DP - 2021 Mar TI - Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry. PG - 106220 LID - S0954-6111(20)30360-7 [pii] LID - 10.1016/j.rmed.2020.106220 [doi] AB - OBJECTIVE: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase 3 randomized trials. The EXPosurE Registry RiociguaT in patients with pulmonary hypertension (EXPERT) study was designed to monitor the long-term safety of riociguat in clinical practice. METHODS: EXPERT was an international, multicenter, prospective, uncontrolled, non-interventional cohort study of patients treated with riociguat. Patients were followed for at least 1 year and up to 4 years from enrollment or until 30 days after stopping riociguat treatment. Primary safety outcomes were adverse events (AEs) and serious adverse events (SAEs) coded using Medical Dictionary for Regulatory Activities preferred terms and System Organ Classes version 21.0, collected during routine clinic visits and collated via case report forms. RESULTS: In total, 956 patients with CTEPH were included in the analysis. The most common AEs in these patients were peripheral edema/edema (11.7%), dizziness (7.5%), right ventricular (RV)/cardiac failure (7.7%), and pneumonia (5.0%). The most common SAEs were RV/cardiac failure (7.4%), pneumonia (4.1%), dyspnea (3.6%), and syncope (2.5%). Exposure-adjusted rates of hemoptysis/pulmonary hemorrhage and hypotension were low and comparable to those in the long-term extension study of riociguat (Chronic Thromboembolic Pulmonary Hypertension Soluble Guanylate Cyclase-Stimulator Trial [CHEST-2]). CONCLUSION: Data from EXPERT show that in patients with CTEPH, the safety of riociguat in routine practice was consistent with the known safety profile of the drug, and no new safety concerns were identified. CI - Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Ghofrani, Hossein-Ardeschir AU - Ghofrani HA AD - University of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany; Member of the German Center for Lung Research (DZL), Giessen, Germany. Electronic address: Ardeschir.Ghofrani@innere.med.uni-giessen.de. FAU - Gomez Sanchez, Miguel-Angel AU - Gomez Sanchez MA AD - Respiratory Department, Ramon y Cajal University Hospital (IRYCIS), Madrid, Spain; Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Spain. FAU - Humbert, Marc AU - Humbert M AD - Universite Paris-Saclay, Inserm U999, Service de Pneumologie et Soins Intensifs Respiratoires, Hopital Bicetre, Le Kremlin-Bicetre, France. FAU - Pittrow, David AU - Pittrow D AD - Institute for Clinical Pharmacology, Technical University, Dresden, Germany. FAU - Simonneau, Gerald AU - Simonneau G AD - Universite Paris-Sud, Le Kremlin-Bicetre, Service de Pneumologie, Centre de Reference de l'Hypertension Pulmonaire Severe, DHU Thorax Innovation, Hopital Bicetre, Le Kremlin-Bicetre, Paris, France. FAU - Gall, Henning AU - Gall H AD - University of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany; Member of the German Center for Lung Research (DZL), Giessen, Germany. FAU - Grunig, Ekkehard AU - Grunig E AD - Centre for Pulmonary Hypertension, Thoraxclinic at Heidelberg University Hospital, Heidelberg, Germany. FAU - Klose, Hans AU - Klose H AD - Department of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FAU - Halank, Michael AU - Halank M AD - Medical Clinic I, Department of Pneumology, University Hospital Carl Gustav Carus, Dresden, Germany. FAU - Langleben, David AU - Langleben D AD - Center for Pulmonary Vascular Disease, Jewish General Hospital, McGill University, Montreal, Quebec, Canada. FAU - Snijder, Repke J AU - Snijder RJ AD - Department of Pulmonology, St Antonius Ziekenhuis, Nieuwegein, the Netherlands. FAU - Escribano Subias, Pilar AU - Escribano Subias P AD - Department of Cardiology, Hospital 12 de Octubre, Madrid, Spain; CIBER-CV (CIBER of Cardiovascular Disease), Hospital 12 de Octubre, Madrid, Spain. FAU - Mielniczuk, Lisa M AU - Mielniczuk LM AD - Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. FAU - Lange, Tobias J AU - Lange TJ AD - Department of Internal Medicine II, Division of Pneumology, University Medical Center, Regensburg, Germany. FAU - Vachiery, Jean-Luc AU - Vachiery JL AD - Departement de Cardiologie, Cliniques Universitaires de Bruxelles, Hopital Erasme, Brussels, Belgium. FAU - Wirtz, Hubert AU - Wirtz H AD - Department of Respiratory Medicine, University of Leipzig, Leipzig, Germany. FAU - Helmersen, Douglas S AU - Helmersen DS AD - Alberta Health Services, University of Calgary, Calgary, Alberta, Canada. FAU - Tsangaris, Iraklis AU - Tsangaris I AD - Second Department of Critical Care, University Hospital Attikon, National and Kapodistrian University of Athens, Athens, Greece. FAU - Barbera, Joan A AU - Barbera JA AD - Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain; Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Madrid, Spain. FAU - Pepke-Zaba, Joanna AU - Pepke-Zaba J AD - Pulmonary Vascular Disease Unit, Royal Papworth Hospital, Cambridge, UK. FAU - Boonstra, Anco AU - Boonstra A AD - VU Medisch Centrum, Amsterdam, the Netherlands. FAU - Rosenkranz, Stephan AU - Rosenkranz S AD - Department III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center, Cologne, Germany. FAU - Ulrich, Silvia AU - Ulrich S AD - Clinic of Pulmonology, University Hospital Zurich, Zurich, Switzerland. FAU - Steringer-Mascherbauer, Regina AU - Steringer-Mascherbauer R AD - Servicestelle fur klinische Studien, Krankenhaus der Elisabethinen Linz GmbH, Linz, Austria. FAU - Delcroix, Marion AU - Delcroix M AD - Department of Respiratory Diseases, University Hospitals of Leuven, and Respiratory Division, Department CHROMETA, KU Leuven - University of Leuven, Leuven, Belgium. FAU - Jansa, Pavel AU - Jansa P AD - 2(nd) Department of Medicine, Department of Cardiovascular Medicine, Charles University in Prague, Prague, Czech Republic. FAU - Simkova, Iveta AU - Simkova I AD - Department of Cardiology and Angiology, Faculty of Medicine, Slovak Medical University & National Institute of Cardiovascular Diseases, Bratislava, Slovak Republic. FAU - Giannakoulas, George AU - Giannakoulas G AD - Department of Cardiology I, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Klotsche, Jens AU - Klotsche J AD - German Rheumatism Research Center Berlin, Leibniz Institute, Berlin, Germany. FAU - Williams, Evgenia AU - Williams E AD - Bayer AG, Global Development, Global Medical Affairs, Berlin, Germany. FAU - Meier, Christian AU - Meier C AD - Bayer AG, Global Development, Global Medical Affairs, Berlin, Germany. FAU - Hoeper, Marius M AU - Hoeper MM AD - Department of Respiratory Medicine and the German Center for Lung Research, Hannover Medical School, Hannover, Germany. CN - NEW COLLABORATORS LIST LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20201112 PL - England TA - Respir Med JT - Respiratory medicine JID - 8908438 RN - 0 (Pyrazoles) RN - 0 (Pyrimidines) RN - RU3FE2Y4XI (riociguat) SB - IM MH - Aged MH - Chronic Disease MH - *Data Analysis MH - Female MH - Humans MH - Hypertension, Pulmonary/*drug therapy/*etiology MH - Male MH - Middle Aged MH - Multicenter Studies as Topic MH - Prospective Studies MH - Pulmonary Embolism/*complications/*drug therapy MH - Pyrazoles/adverse effects/*therapeutic use MH - Pyrimidines/adverse effects/*therapeutic use MH - Randomized Controlled Trials as Topic MH - Recurrence MH - *Registries MH - Safety MH - Time Factors MH - Treatment Outcome OTO - NOTNLM OT - Chronic thromboembolic pulmonary hypertension OT - Clinical practice OT - Real-world OT - Registry OT - Riociguat OT - Safety FIR - Caneva, Jorge IR - Caneva J IRAD- Pneumonology Service, Hospital Universitario Fundacion Favaloro, Buenos Aires, Argentina. FIR - Tuhay, Graciela IR - Tuhay G IRAD- Pneumonology Service, Hospital Universitario Fundacion Favaloro, Buenos Aires, Argentina. FIR - Diez, Mirta IR - Diez M IRAD- Clinical Cardiology Service, ICBA - Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina. FIR - Talavera, Maria Lujan IR - Talavera ML IRAD- Clinical Cardiology Service, ICBA - Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina. FIR - Acosta, Adriana IR - Acosta A IRAD- Clinical Cardiology Service, ICBA - Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina. FIR - Vulcano, Norberto IR - Vulcano N IRAD- Department of Cardiology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. FIR - Bosio, Martin IR - Bosio M IRAD- Center for Respiratory Medicine, Hospital Britanico, Buenos Aires, Argentina. FIR - Maldonado, Lorena IR - Maldonado L IRAD- Center for Respiratory Medicine, Hospital Britanico, Buenos Aires, Argentina. FIR - Deleo, Sabino IR - Deleo S IRAD- Pneumonology, Cen Asma Centro de Enfermedades Respiratorias, Buenos Aires, Argentina. FIR - Melatini, Luciano IR - Melatini L IRAD- Pneumonology, Instituto Diagnostico, Buenos Aires, Argentina. FIR - Keogh, Anne IR - Keogh A IRAD- Heart Lung Clinic, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia. FIR - Kotlyar, Eugene IR - Kotlyar E IRAD- Heart Lung Clinic, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia. FIR - Feenstra, John IR - Feenstra J IRAD- Queensland Lung Transplant Service (QLTS), Prince Charles Hospital, Chermside, QLD, Australia. FIR - Dwyer, Nathan IR - Dwyer N IRAD- Department of Cardiology, Royal Hobart Hospital, Hobart, Tasmania, Australia. FIR - Adams, Heath IR - Adams H IRAD- Department of Cardiology, Royal Hobart Hospital, Hobart, Tasmania, Australia. FIR - Stevens, Wendy IR - Stevens W IRAD- Rheumatology Department, St Vincent's Hospital, Melbourne, Victoria, Australia. FIR - Steele, Peter IR - Steele P IRAD- Clinical Trials Centre, Cardiology Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia. FIR - Proudman, Susanna IR - Proudman S IRAD- Clinical Trials Centre, Cardiology Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia. FIR - Minson, Robert IR - Minson R IRAD- Flinders Cardiac Clinic, Flinders Medical Centre, Bedford Park, South Australia, Australia. FIR - Reeves, Glenn IR - Reeves G IRAD- Immunology Department, John Hunter Hospital, Newcastle, New South Wales, Australia. FIR - Lavender, Melanie IR - Lavender M IRAD- Advanced Lung Disease Unit, Fiona Stanley Hospital, Murdoch, Western Australia, Australia. FIR - Ng, Benjamin IR - Ng B IRAD- Nepean Hospital, Kingswood, New South Wales, Australia. FIR - Mackenzie, Michele IR - Mackenzie M IRAD- Nepean Hospital, Kingswood, New South Wales, Australia. FIR - Barry, Lisa IR - Barry L IRAD- Nepean Hospital, Kingswood, New South Wales, Australia. FIR - Gruenberger, Margarethe IR - Gruenberger M IRAD- Servicestelle fur klinische Studien, Krankenhaus der Elisabethinen Linz GmbH, Linz, Austria. FIR - Huber, Charlotte IR - Huber C IRAD- Servicestelle fur klinische Studien, Krankenhaus der Elisabethinen Linz GmbH, Linz, Austria. FIR - Lang, Irene IR - Lang I IRAD- Clinical Department of Cardiology, Medical University of Vienna, Vienna, Austria. FIR - Tilea, Ioana IR - Tilea I IRAD- Clinical Department of Cardiology, Medical University of Vienna, Vienna, Austria. FIR - Sadushi-Kolici, Roela IR - Sadushi-Kolici R IRAD- Clinical Department of Cardiology, Medical University of Vienna, Vienna, Austria. FIR - Loffler-Ragg, Judith IR - Loffler-Ragg J IRAD- Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria. FIR - Feistmantl, Lisa-Theresa IR - Feistmantl LT IRAD- Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria. FIR - Evrard, Patrick IR - Evrard P IRAD- Department of Intensive Care, Centre Hospitalier Universite Dinant-Mont-Godinne, Yvoir, Belgium. FIR - Louis, Renaud IR - Louis R IRAD- Department of Pulmonary Medicine, Centre Hospitalier Universite Liege, Liege, Belgium. FIR - Guiot, Julien IR - Guiot J IRAD- Department of Pulmonary Medicine, Centre Hospitalier Universite Liege, Liege, Belgium. FIR - Naldi, Marco IR - Naldi M IRAD- Department of Pulmonary Medicine, Centre Hospitalier Universite Liege, Liege, Belgium. FIR - De Pauw, Michel IR - De Pauw M IRAD- Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, Belgium. FIR - Mehta, Sanjay IR - Mehta S IRAD- Centre for Critical Illness Research, Lawson Health Research Institute, London, Ontario, Canada. FIR - Camacho, Rafael Conde IR - Camacho RC IRAD- Internal Medicine and Pneumonology, Fundacion Neumologica, Bogota, Colombia. FIR - Tovar, Patricia Parada IR - Tovar PP IRAD- Internal Medicine and Pneumonology, Fundacion Neumologica, Bogota, Colombia. FIR - Londono, Alejandro IR - Londono A IRAD- Pneumonology Department, Clinica Cardio, VID, Medellin, Colombia. FIR - Campo, Felipe IR - Campo F IRAD- Pneumonology Department, Clinica Cardio, VID, Medellin, Colombia. FIR - Garcia, Paula IR - Garcia P IRAD- Pneumonology Department, Clinica Cardio, VID, Medellin, Colombia. FIR - Lema, Camila IR - Lema C IRAD- Pneumonology Department, Clinica Cardio, VID, Medellin, Colombia. FIR - Orozco-Levi, Mauricio IR - Orozco-Levi M IRAD- Pneumonology Service, Fundacion Cardiovascular de Colombia, Floridablanca, Santander, Colombia. FIR - Martinez, William IR - Martinez W IRAD- Valle de Lili Foundation, Cali, Colombia. FIR - Gomez, Juan Esteban IR - Gomez JE IRAD- Valle de Lili Foundation, Cali, Colombia. FIR - Nielsen-Kudsk, Jens Erik IR - Nielsen-Kudsk JE IRAD- Department of Clinical Medicine, Aarhus University Hospital Skejby, Aarhus, Denmark. FIR - Mellemkjaer, Soren IR - Mellemkjaer S IRAD- Department of Clinical Medicine, Aarhus University Hospital Skejby, Aarhus, Denmark. FIR - Anton, Ly IR - Anton L IRAD- Centre of Cardiology, North Estonia Medical Centre Foundation, Tallinn, Estonia. FIR - Altraja, Alan IR - Altraja A IRAD- Department of Pulmonology, Tartu University Hospital, Tartu, Estonia. FIR - Vihinen, Tapani IR - Vihinen T IRAD- Heart Center, Sydankeskus Turku University Hospital, Turku, Finland. FIR - Vasankari, Tuija IR - Vasankari T IRAD- Heart Center, Sydankeskus Turku University Hospital, Turku, Finland. FIR - Sitbon, Olivier IR - Sitbon O IRAD- Hopital Bicetre, Le Kremlin-Bicetre, France. FIR - Cottin, Vincent IR - Cottin V IRAD- National Reference Centre for Rare Pulmonary Diseases, Hopital Louis Pradel, Lyon, France. FIR - Tetu, Laurent IR - Tetu L IRAD- Pneumonology Service, Hopital Larrey, Toulouse, France. FIR - Noel-Savina, Elise IR - Noel-Savina E IRAD- Pneumonology Service, Hopital Larrey, Toulouse, France. FIR - Shearman, Nicole IR - Shearman N IRAD- Department of Respiratory Medicine and the German Center for Lung Research, Hannover Medical School, Hannover, Germany. FIR - Tayler, Susanne IR - Tayler S IRAD- Department of Respiratory Medicine and the German Center for Lung Research, Hannover Medical School, Hannover, Germany. FIR - Olzik, Ilona IR - Olzik I IRAD- Department of Respiratory Medicine and the German Center for Lung Research, Hannover Medical School, Hannover, Germany. FIR - Kulka, Christine IR - Kulka C IRAD- Department of Pneumology, University Hospital Carl Gustav Carus, Dresden, Germany. FIR - Grimminger, Jan IR - Grimminger J IRAD- Department of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FIR - Simon, Marcel IR - Simon M IRAD- Department of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FIR - Nolde, Anna IR - Nolde A IRAD- Department of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FIR - Oqueka, Tim IR - Oqueka T IRAD- Department of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FIR - Harbaum, Lars IR - Harbaum L IRAD- Department of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FIR - Egenlauf, Benjamin IR - Egenlauf B IRAD- Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany. FIR - Ewert, Ralf IR - Ewert R IRAD- Department of Internal Medicine, Clinic and Polyclinic for Internal Medicine B, Greifswald, Germany. FIR - Schulz, Christian IR - Schulz C IRAD- Department of Internal Medicine II, Division of Pneumology, University Medical Center, Regensburg, Germany. FIR - Regotta, Sabine IR - Regotta S IRAD- Department of Internal Medicine II, Division of Pneumology, University Medical Center, Regensburg, Germany. FIR - Kramer, Tilmann IR - Kramer T IRAD- Department III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center, Cologne, Germany. FIR - Knoop-Busch, Susanne IR - Knoop-Busch S IRAD- Department III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center, Cologne, Germany. FIR - Gerhardt, Felix IR - Gerhardt F IRAD- Department III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center, Cologne, Germany. FIR - Konstantinides, Stavros IR - Konstantinides S IRAD- Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany. FIR - Pitsiou, Georgia IR - Pitsiou G IRAD- Respiratory Insufficiency Unit, "G. Papanikolaou" General Hospital of Thessaloniki, Thessaloniki, Greece. FIR - Stanopoulos, Ioannis IR - Stanopoulos I IRAD- Respiratory Insufficiency Unit, "G. Papanikolaou" General Hospital of Thessaloniki, Thessaloniki, Greece. FIR - Sourla, Evdokia IR - Sourla E IRAD- Respiratory Insufficiency Unit, "G. Papanikolaou" General Hospital of Thessaloniki, Thessaloniki, Greece. FIR - Mouratoglou, Sofia IR - Mouratoglou S IRAD- Department of Cardiology I, Aristotle University of Thessaloniki, Thessaloniki, Greece. FIR - Karvounis, Haralambos IR - Karvounis H IRAD- Department of Cardiology I, Aristotle University of Thessaloniki, Thessaloniki, Greece. FIR - Pappas, Athanasios IR - Pappas A IRAD- Second Department of Critical Care, University Hospital Attikon, National and Kapodistrian University of Athens, Athens, Greece. FIR - Georgopoulos, Dimitrios IR - Georgopoulos D IRAD- Department of Intensive Care Medicine, University Hospital of Heraklion, Heraklion, Greece. FIR - Fanaridis, Michail IR - Fanaridis M IRAD- Department of Intensive Care Medicine, University Hospital of Heraklion, Heraklion, Greece. FIR - Mitrouska, Ioanna IR - Mitrouska I IRAD- Department of Intensive Care Medicine, University Hospital of Heraklion, Heraklion, Greece. FIR - Michalis, Lampros IR - Michalis L IRAD- 2nd Department of Cardiology, University Hospital of Ioannina, Ioannina, Greece. FIR - Pappas, Konstantinos IR - Pappas K IRAD- Division of Cardiology, University Hospital of Ioannina, Ioannina, Greece. FIR - Kotsia, Anna IR - Kotsia A IRAD- Division of Cardiology, University Hospital of Ioannina, Ioannina, Greece. FIR - Gaine, Sean IR - Gaine S IRAD- National Pulmonary Hypertension Unit, Mater Misericordiae University Hospital, Dublin, Ireland. FIR - Vizza, Carmine Dario IR - Vizza CD IRAD- Policlinico Umberto I, Department of Cardiovascular, Respiratory, Nephrological, Anaesthesiological, and Geriatric Sciences, La Sapienza Hospital, Rome, Italy. FIR - Manzi, Giovanna IR - Manzi G IRAD- Policlinico Umberto I, Department of Cardiovascular, Respiratory, Nephrological, Anaesthesiological, and Geriatric Sciences, La Sapienza Hospital, Rome, Italy. FIR - Poscia, Roberto IR - Poscia R IRAD- Policlinico Umberto I, Department of Cardiovascular, Respiratory, Nephrological, Anaesthesiological, and Geriatric Sciences, La Sapienza Hospital, Rome, Italy. FIR - Badagliacca, Roberto IR - Badagliacca R IRAD- Policlinico Umberto I, Department of Cardiovascular, Respiratory, Nephrological, Anaesthesiological, and Geriatric Sciences, La Sapienza Hospital, Rome, Italy. FIR - Agostoni, Piergiuseppe IR - Agostoni P IRAD- Monzino Cardiology Center Hospital, Milan, Italy. FIR - Bruno, Noemi IR - Bruno N IRAD- Monzino Cardiology Center Hospital, Milan, Italy. FIR - Farina, Stefania IR - Farina S IRAD- Monzino Cardiology Center Hospital, Milan, Italy. FIR - D'Alto, Michele IR - D'Alto M IRAD- Department of Cardiology, Monaldi Hospital, Naples, Italy. FIR - Argiento, Paola IR - Argiento P IRAD- Department of Cardiology, Monaldi Hospital, Naples, Italy. FIR - Correra, Anna IR - Correra A IRAD- Department of Cardiology, Monaldi Hospital, Naples, Italy. FIR - Di Marco, Giovanni Maria IR - Di Marco GM IRAD- Department of Cardiology, Monaldi Hospital, Naples, Italy. FIR - Cresci, Chiara IR - Cresci C IRAD- Pneumology Unit, Careggi University Hospital, Florence, Italy. FIR - Vannucchi, Vieri IR - Vannucchi V IRAD- Pneumology Unit, Careggi University Hospital, Florence, Italy. FIR - Torricelli, Elena IR - Torricelli E IRAD- Pneumology Unit, Careggi University Hospital, Florence, Italy. FIR - Garcea, Alessio IR - Garcea A IRAD- Pneumology Unit, Careggi University Hospital, Florence, Italy. FIR - Pesci, Alberto IR - Pesci A IRAD- Pneumology Clinic, Cardiothoracic and Vascular Department, San Gerardo Hospital, Monza, Italy. FIR - Sardella, Luca IR - Sardella L IRAD- Pneumology Clinic, Cardiothoracic and Vascular Department, San Gerardo Hospital, Monza, Italy. FIR - Paciocco, Giuseppe IR - Paciocco G IRAD- Pneumology Clinic, Cardiothoracic and Vascular Department, San Gerardo Hospital, Monza, Italy. FIR - Pane, Federico IR - Pane F IRAD- Pneumology Clinic, Cardiothoracic and Vascular Department, San Gerardo Hospital, Monza, Italy. FIR - D'Armini, Andrea Maria IR - D'Armini AM IRAD- Cardiothoracic and Vascular Department, Policlinico San Matteo, Pavia, Italy. FIR - Pin, Maurizio IR - Pin M IRAD- Cardiothoracic and Vascular Department, Policlinico San Matteo, Pavia, Italy. FIR - Grazioli, Valentina IR - Grazioli V IRAD- Cardiothoracic and Vascular Department, Policlinico San Matteo, Pavia, Italy. FIR - Massola, Giulia IR - Massola G IRAD- Cardiothoracic and Vascular Department, Policlinico San Matteo, Pavia, Italy. FIR - Sciortino, Antonio IR - Sciortino A IRAD- Cardiothoracic and Vascular Department, Policlinico San Matteo, Pavia, Italy. FIR - Prediletto, Renato IR - Prediletto R IRAD- Institute of Clinical Physiology, Toscana Gabriele Monasterio Foundation, CNR Research Area, Pisa, Italy. FIR - Bauleo, Carolina IR - Bauleo C IRAD- Institute of Clinical Physiology, Toscana Gabriele Monasterio Foundation, CNR Research Area, Pisa, Italy. FIR - Airo, Edoardo IR - Airo E IRAD- Institute of Clinical Physiology, Toscana Gabriele Monasterio Foundation, CNR Research Area, Pisa, Italy. FIR - Ndreu, Rudina IR - Ndreu R IRAD- Institute of Clinical Physiology, Toscana Gabriele Monasterio Foundation, CNR Research Area, Pisa, Italy. FIR - Pavlickova, Ivana IR - Pavlickova I IRAD- Institute of Clinical Physiology, Toscana Gabriele Monasterio Foundation, CNR Research Area, Pisa, Italy. FIR - Lunardi, Claudio IR - Lunardi C IRAD- Department of Medicine, Integrated University Hospital Verona, Verona, Italy. FIR - Mule, Massimiliano IR - Mule M IRAD- Department of Cardiology, Policlinico Vittorio Emanuele, Catania, Italy. FIR - Farruggio, Silvia IR - Farruggio S IRAD- Department of Cardiology, Policlinico Vittorio Emanuele, Catania, Italy. FIR - Costa, Serena IR - Costa S IRAD- Department of Cardiology, Policlinico Vittorio Emanuele, Catania, Italy. FIR - Galgano, Giuseppe IR - Galgano G IRAD- Division of Cardiology, Miulli General Hospital, Fonti-Bari, Italy. FIR - Petruzzi, Mario IR - Petruzzi M IRAD- Division of Cardiology, Miulli General Hospital, Fonti-Bari, Italy. FIR - De Luca, Anna IR - De Luca A IRAD- Division of Cardiology, Miulli General Hospital, Fonti-Bari, Italy. FIR - Lombardi, Francesco IR - Lombardi F IRAD- Division of Cardiology, Miulli General Hospital, Fonti-Bari, Italy. FIR - Roncon, Loris IR - Roncon L IRAD- Department of Cardiology, Hospital Santa Maria della Misericordia, Rovigo, Italy. FIR - Conte, Luca IR - Conte L IRAD- Department of Cardiology, Hospital Santa Maria della Misericordia, Rovigo, Italy. FIR - Picariello, Claudio IR - Picariello C IRAD- Department of Cardiology, Hospital Santa Maria della Misericordia, Rovigo, Italy. FIR - Wirtz, Gil IR - Wirtz G IRAD- Pneumology Service, Centre Hospitalier de Luxembourg, Luxembourg. FIR - Alexandre, Myriam IR - Alexandre M IRAD- Pneumology Service, Centre Hospitalier de Luxembourg, Luxembourg. FIR - Vonk-Noordegraaf, A IR - Vonk-Noordegraaf A IRAD- VU Medisch Centrum, Amsterdam, the Netherlands. FIR - Boogaard, H IR - Boogaard H IRAD- VU Medisch Centrum, Amsterdam, the Netherlands. FIR - Mager, J IR - Mager J IRAD- Department of Pulmonology, St Antonius Ziekenhuis, Nieuwegein, the Netherlands. FIR - Reesink, H IR - Reesink H IRAD- Department of Pulmonology, St Antonius Ziekenhuis, Nieuwegein, the Netherlands. FIR - van den Toorn, Leon M IR - van den Toorn LM IRAD- Department of Pulmonary Diseases, Erasmus Medical Centre, Rotterdam, the Netherlands. FIR - Boomars, Karin IR - Boomars K IRAD- Department of Pulmonary Diseases, Erasmus Medical Centre, Rotterdam, the Netherlands. FIR - Andreassen, Arne K IR - Andreassen AK IRAD- Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway. FIR - Castro, Graca IR - Castro G IRAD- Department of Cardiology, Coimbra Hospital and University Center, Coimbra, Portugal. FIR - Tania, Goncalves IR - Tania G IRAD- Department of Cardiology, Coimbra Hospital and University Center, Coimbra, Portugal. FIR - Baptista, Rui IR - Baptista R IRAD- Department of Cardiology, Coimbra Hospital and University Center, Coimbra, Portugal. FIR - Marinho, Antonio IR - Marinho A IRAD- Department of Cardiology, Coimbra Hospital and University Center, Coimbra, Portugal. FIR - Shiang, Teresa IR - Shiang T IRAD- Department of Pneumology, Hospital Center Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal. FIR - Oliveira, Ana IR - Oliveira A IRAD- Department of Pneumology, Hospital Center Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal. FIR - Coutinho, Daniel IR - Coutinho D IRAD- Department of Pneumology, Hospital Center Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal. FIR - Sousa, Joana IR - Sousa J IRAD- Department of Pneumology, Hospital Center Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal. FIR - Loureiro, Maria Jose IR - Loureiro MJ IRAD- Cardiology Department, Hospital Garcia de Orta, E.P.E., Almada, Portugal. FIR - Repolho, Debora IR - Repolho D IRAD- Cardiology Department, Hospital Garcia de Orta, E.P.E., Almada, Portugal. FIR - Martins Jesus, Susana Maria IR - Martins Jesus SM IRAD- Department of Medicine I, North Lisbon Hospital Center, Lisbon, Portugal. FIR - Capinha, Marta IR - Capinha M IRAD- Department of Medicine I, North Lisbon Hospital Center, Lisbon, Portugal. FIR - Agostinho, Joao IR - Agostinho J IRAD- Department of Medicine I, North Lisbon Hospital Center, Lisbon, Portugal. FIR - Cardoso, Tania IR - Cardoso T IRAD- Department of Medicine I, North Lisbon Hospital Center, Lisbon, Portugal. FIR - Rocha, Andreia IR - Rocha A IRAD- Department of Medicine I, North Lisbon Hospital Center, Lisbon, Portugal. FIR - Espinha, Mafalda IR - Espinha M IRAD- Department of Medicine I, North Lisbon Hospital Center, Lisbon, Portugal. FIR - Ivanov, Kyundyul Ivanovich IR - Ivanov KI IRAD- State Budgetary Institution of the Republic of Sakha (Yakutia) "Republican Hospital numero sign1 - National Center for Medicine", Yakutsk, Russia. FIR - Alexeeva, Dalyana Eduardovna IR - Alexeeva DE IRAD- State Budgetary Institution of the Republic of Sakha (Yakutia) "Republican Hospital numero sign1 - National Center for Medicine", Yakutsk, Russia. FIR - Batalina, Marina Vadimovna IR - Batalina MV IRAD- State Educational Institution of Higher Professional Education "Orenburg State Medical University", Orenburg, Russia. FIR - Hegya, Daria Viktorovna IR - Hegya DV IRAD- State Budgetary Healthcare Institution "Primorskaya Regional Clinical Hospital numero sign1", Vladivostok, Russia. FIR - Zvereva, Tatyana Nikolaevna IR - Zvereva TN IRAD- Federal State Budgetary Scientific Institution "Research Institute for Complex Problems of Cardiovascular Diseases", Kemerovo, Russia. FIR - Avdeev, Sergey Nikolaevich IR - Avdeev SN IRAD- Federal State Budgetary Institution "Scientific Research Institute of Pulmonology of the Federal Bio-Medical Agency", Moscow, Russia. FIR - Tsareva, Natalia Anatolievna IR - Tsareva NA IRAD- Federal State Budgetary Institution "Scientific Research Institute of Pulmonology of the Federal Bio-Medical Agency", Moscow, Russia. FIR - Galyavich, Albert Sarvatovich IR - Galyavich AS IRAD- State Budgetary Institution of High Professional Education "Kazan State Medical University", Kazan, Russia. FIR - Nikolaevich, Bykov Aleksander IR - Nikolaevich BA IRAD- State Budgetary Healthcare Institution "Sverdlovsk Regional Clinical Hospital No.1", Yekaterinburg, Russia. FIR - Filippov, Evgeny Vladimirovich IR - Filippov EV IRAD- State Budget Institution of the Ryazan Region "Regional Clinical Cardiology Dispensary", Ryazan, Russia. FIR - Yakovleva, Olga Eduardovna IR - Yakovleva OE IRAD- Chelyabinsk Regional Cardiology Clinic, Chelyabinsk, Russia. FIR - Pavlova, Olga Borisovna IR - Pavlova OB IRAD- Perm Regional State Budgetary Healthcare Institution "Clinical Cardiologic Dispensary", Perm, Russia. FIR - Skripkina, Elena Sergeevna IR - Skripkina ES IRAD- State Autonomous Healthcare Institution Amur Region "Amur Regional Clinical Hospital", Blagoveschensk, Russia. FIR - Martynyuk, Tamila Vitalievna IR - Martynyuk TV IRAD- Federal State Budget Institution "Russian Cardiology Research and Production Complex" of the Russian Federation, Moscow, Russia. FIR - Bukatova, Irina Fedorovna IR - Bukatova IF IRAD- Regional State Budgetary Healthcare Institution "Regional Clinical Hospital numero sign1", Khabarovsk, Russia. FIR - Tregubova, Anna Viktorovna IR - Tregubova AV IRAD- State Budgetary Healthcare Institution "Volgograd Regional Clinical Cardiology Center", Volgograd, Russia. FIR - Platonov, Dmitry Yurievich IR - Platonov DY IRAD- State Budgetary Healthcare Institution "Regional Clinical Hospital", Tver, Russia. FIR - Kolomeytseva, Tatyana Mikhaylovna IR - Kolomeytseva TM IRAD- State Healthcare Institution "City Hospital No.13 in Tula", Tula, Russia. FIR - Al Dalaan, Abdullah IR - Al Dalaan A IRAD- Pulmonary Medicine Section, Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. FIR - Abdelsayed, Abeer Abeer IR - Abdelsayed AA IRAD- Pulmonary Medicine Section, Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. FIR - Weheba, Ihab IR - Weheba I IRAD- Pulmonary Medicine Section, Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. FIR - Saleemi, Sarferaz IR - Saleemi S IRAD- Pulmonary Medicine Section, Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. FIR - Sakkijha, Hussam IR - Sakkijha H IRAD- Pulmonary Medicine, King Fahad Medical City, Riyadh, Saudi Arabia. FIR - Bohacekova, Marcela IR - Bohacekova M IRAD- Department of Cardiology and Angiology, Faculty of Medicine, Slovak Medical University & National Institute of Cardiovascular Diseases, Bratislava, Slovak Republic. FIR - Valkovicova, Tatiana IR - Valkovicova T IRAD- Department of Cardiology and Angiology, Faculty of Medicine, Slovak Medical University & National Institute of Cardiovascular Diseases, Bratislava, Slovak Republic. FIR - Farkasova, Iveta IR - Farkasova I IRAD- Department of Cardiology and Angiology, Faculty of Medicine, Slovak Medical University & National Institute of Cardiovascular Diseases, Bratislava, Slovak Republic. FIR - Quezada, Carlos Andres IR - Quezada CA IRAD- Department of Cardiology, Hospital 12 de Octubre, Madrid, Spain. FIR - Piccari, Lucilla IR - Piccari L IRAD- Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain. FIR - Blanco, Isabel IR - Blanco I IRAD- Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain. FIR - Sebastian, Laura IR - Sebastian L IRAD- Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain. FIR - Roman, Antonio IR - Roman A IRAD- Department of Medicine, Hospital Vall Hebron, Barcelona, Spain. FIR - Lopez, Manuel IR - Lopez M IRAD- Department of Medicine, Hospital Vall Hebron, Barcelona, Spain. FIR - Otero, Remedios IR - Otero R IRAD- Medical-Surgical Unit of Respiratory Diseases, University Hospital Virgen Del Rocio, Seville, Spain. FIR - Elias, Teresa IR - Elias T IRAD- Medical-Surgical Unit of Respiratory Diseases, University Hospital Virgen Del Rocio, Seville, Spain. FIR - Jara, Luis IR - Jara L IRAD- Medical-Surgical Unit of Respiratory Diseases, University Hospital Virgen Del Rocio, Seville, Spain. FIR - Asencio, Isabel IR - Asencio I IRAD- Medical-Surgical Unit of Respiratory Diseases, University Hospital Virgen Del Rocio, Seville, Spain. FIR - Arjona, Josefa Jimenez IR - Arjona JJ IRAD- Department of Internal Medicine, Hospital De Jerez, Jerez De La Frontera, Spain. FIR - Almagro, Raul Menor IR - Almagro RM IRAD- Department of Internal Medicine, Hospital De Jerez, Jerez De La Frontera, Spain. FIR - Cardenas, Salvador Lopez IR - Cardenas SL IRAD- Department of Internal Medicine, Hospital De Jerez, Jerez De La Frontera, Spain. FIR - Garcia, Salvador Alcaraz IR - Garcia SA IRAD- Department of Internal Medicine, Hospital De Jerez, Jerez De La Frontera, Spain. FIR - Rodriguez, Patricia Villanueva IR - Rodriguez PV IRAD- Department of Internal Medicine, Hospital De Jerez, Jerez De La Frontera, Spain. FIR - Lopez, Raquel IR - Lopez R IRAD- Pneumology Department, Hospital La Fe, Valencia, Spain. FIR - Garcia, Alberto IR - Garcia A IRAD- Pneumology Department, Hospital La Fe, Valencia, Spain. FIR - Aviles, Francisco Fernandez IR - Aviles FF IRAD- Department of Cardiology, Hospital Gregorio Maranon, Madrid, Spain. FIR - De La Pava, Sebastian IR - De La Pava S IRAD- Department of Cardiology, Hospital Gregorio Maranon, Madrid, Spain. FIR - Yotti, Raquel IR - Yotti R IRAD- Department of Cardiology, Hospital Gregorio Maranon, Madrid, Spain. FIR - Penate, Gregorio Perez IR - Penate GP IRAD- Pneumology Service, Hospital Dr Negrin, Las Palmas, Spain. FIR - Marrero, Fernando Leon IR - Marrero FL IRAD- Pneumology Service, Hospital Dr Negrin, Las Palmas, Spain. FIR - Cifrian Martinez, Jose Manuel IR - Cifrian Martinez JM IRAD- Servicio de Anestesiologia y Reanimacion, Hospital Marques de Valdecilla, Santander, Spain. FIR - Martinez-Menaca, Amaya IR - Martinez-Menaca A IRAD- Servicio de Anestesiologia y Reanimacion, Hospital Marques de Valdecilla, Santander, Spain. FIR - Alonso, Lecue Pilar IR - Alonso LP IRAD- Servicio de Anestesiologia y Reanimacion, Hospital Marques de Valdecilla, Santander, Spain. FIR - Rozas, Sonia Fernandez IR - Rozas SF IRAD- Servicio de Anestesiologia y Reanimacion, Hospital Marques de Valdecilla, Santander, Spain. FIR - Fernandez, David Iturbe IR - Fernandez DI IRAD- Servicio de Anestesiologia y Reanimacion, Hospital Marques de Valdecilla, Santander, Spain. FIR - Cuesta, Victor Mora IR - Cuesta VM IRAD- Servicio de Anestesiologia y Reanimacion, Hospital Marques de Valdecilla, Santander, Spain. FIR - Soderberg, Stefan IR - Soderberg S IRAD- Heart Center, Norrland University Hospital, Umea, Sweden. FIR - Bartfay, Sven-Erik IR - Bartfay SE IRAD- Department of Cardiology, Sahlgrenska University Hospital, Goteborg, Sweden. FIR - Rundqvist, Bengt IR - Rundqvist B IRAD- Department of Cardiology, Sahlgrenska University Hospital, Goteborg, Sweden. FIR - Alfetlawi, Monthir IR - Alfetlawi M IRAD- Department of Cardiology, Linkoping University Hospital, Linkoping, Sweden. FIR - Wodlin, Peter IR - Wodlin P IRAD- Department of Cardiology, Linkoping University Hospital, Linkoping, Sweden. FIR - Schwarz, Esther Irene IR - Schwarz EI IRAD- Clinic of Pulmonology, University Hospital Zurich, Zurich, Switzerland. FIR - Speich, Rudolf IR - Speich R IRAD- Clinic of Pulmonology, University Hospital Zurich, Zurich, Switzerland. FIR - Lador, Frederic IR - Lador F IRAD- Pulmonary Division, Geneva University Hospitals, Geneva, Switzerland. FIR - Rochat, Thierry IR - Rochat T IRAD- Pulmonary Division, Geneva University Hospitals, Geneva, Switzerland. FIR - Gasche-Soccal, Paola IR - Gasche-Soccal P IRAD- Pulmonary Division, Geneva University Hospitals, Geneva, Switzerland. FIR - Hsu, Chih-Hsin IR - Hsu CH IRAD- Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City, Taiwan. FIR - Lin, Tsung-Hsien IR - Lin TH IRAD- Department of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. FIR - Su, Ho-Ming IR - Su HM IRAD- Department of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. FIR - Lai, Wen-Ter IR - Lai WT IRAD- Department of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. FIR - Chu, Chun Yuan IR - Chu CY IRAD- Department of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. FIR - Hsu, Po-Chao IR - Hsu PC IRAD- Department of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. FIR - Voon, Wen-Chol IR - Voon WC IRAD- Department of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. FIR - Yen, Hsueh-Wei IR - Yen HW IRAD- Department of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. FIR - Yih-Jer Wu, Jacob IR - Yih-Jer Wu J IRAD- Cardiovascular Center, Mackay Memorial Hospital, Taipei City, Taiwan. FIR - Wu, Shu-Hao IR - Wu SH IRAD- Cardiovascular Center, Mackay Memorial Hospital, Taipei City, Taiwan. FIR - Huang, Wen-Pin IR - Huang WP IRAD- Division of Cardiology, Heart Center, Cheng Hsin General Hospital, Taipei City, Taiwan. FIR - Fong, Man-Cai IR - Fong MC IRAD- Division of Cardiology, Heart Center, Cheng Hsin General Hospital, Taipei City, Taiwan. FIR - Huang, Chien-Lung IR - Huang CL IRAD- Division of Cardiology, Heart Center, Cheng Hsin General Hospital, Taipei City, Taiwan. FIR - Kuo, Ping-Hung IR - Kuo PH IRAD- Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan. FIR - Lin, Yen-Hung IR - Lin YH IRAD- Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan. FIR - Lin, Jiunn-Lee IR - Lin JL IRAD- Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan. FIR - Hung, Chi-Sheng IR - Hung CS IRAD- Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan. FIR - Wu, Cho-Kai IR - Wu CK IRAD- Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan. FIR - Sung, Shih-Hsien IR - Sung SH IRAD- Department of Medicine, Taipei Veterans General Hospital, Taipei City, Taiwan. FIR - Huang, Wei-Chun IR - Huang WC IRAD- Department of Cardiology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan. FIR - Cheng, Chin-Chang IR - Cheng CC IRAD- Department of Cardiology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan. FIR - Kuo, Shu-Hung IR - Kuo SH IRAD- Department of Cardiology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan. FIR - Wang, Wen-Hwa IR - Wang WH IRAD- Department of Cardiology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan. FIR - Ho, Wan-Jing IR - Ho WJ IRAD- Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan County, Taiwan. FIR - Hsu, Tsu-Shiu IR - Hsu TS IRAD- Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan County, Taiwan. FIR - Mutlu, Bulent IR - Mutlu B IRAD- Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey. FIR - Atas, Halil IR - Atas H IRAD- Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey. FIR - Ongen, Gul IR - Ongen G IRAD- Department of Chest Diseases, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey. FIR - Un, Zeynep IR - Un Z IRAD- Department of Chest Diseases, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey. FIR - Okumus, Gulfer IR - Okumus G IRAD- Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FIR - Un, Zeynep IR - Un Z IRAD- Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FIR - Hanta, Ismail IR - Hanta I IRAD- Department of Respiratory Medicine, Cukurova University, Adana, Turkey. FIR - Corris, Paul IR - Corris P IRAD- Department of Respiratory Medicine, Freeman Hospital, Newcastle, United Kingdom. FIR - Peacock, Andrew IR - Peacock A IRAD- Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Clydebank, West Dunbartonshire, United Kingdom. FIR - Church, Colin IR - Church C IRAD- Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Clydebank, West Dunbartonshire, United Kingdom. FIR - Toshner, Mark IR - Toshner M IRAD- Pulmonary Vascular Disease Unit, Royal Papworth Hospital, Cambridge, United Kingdom. FIR - Newnham, Michael IR - Newnham M IRAD- Pulmonary Vascular Disease Unit, Royal Papworth Hospital, Cambridge, United Kingdom. EDAT- 2021/02/05 06:00 MHDA- 2021/10/09 06:00 CRDT- 2021/02/04 20:19 PHST- 2020/05/17 00:00 [received] PHST- 2020/11/05 00:00 [revised] PHST- 2020/11/06 00:00 [accepted] PHST- 2021/02/05 06:00 [pubmed] PHST- 2021/10/09 06:00 [medline] PHST- 2021/02/04 20:19 [entrez] AID - S0954-6111(20)30360-7 [pii] AID - 10.1016/j.rmed.2020.106220 [doi] PST - ppublish SO - Respir Med. 2021 Mar;178:106220. doi: 10.1016/j.rmed.2020.106220. Epub 2020 Nov 12.