PMID- 33540749
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240331
IS  - 2309-608X (Electronic)
IS  - 2309-608X (Linking)
VI  - 7
IP  - 2
DP  - 2021 Feb 2
TI  - One Century of Study: What We Learned about Paracoccidioides and How This 
      Pathogen Contributed to Advances in Antifungal Therapy.
LID - 10.3390/jof7020106 [doi]
LID - 106
AB  - Paracoccidioidomycosis (PCM) is a notable fungal infection restricted to Latin 
      America. Since the first description of the disease by Lutz up to the present 
      day, Brazilian researchers have contributed to the understanding of the life 
      cycle of this pathogen and provided the possibility of new targets for antifungal 
      therapy based on the structural and functional genomics of Paracoccidioides. In 
      this context, in silico approaches have selected molecules that act on specific 
      targets, such as the thioredoxin system, with promising antifungal activity 
      against Paracoccidioides. Some of these are already in advanced development 
      stages. In addition, the application of nanostructured systems has addressed 
      issues related to the high toxicity of conventional PCM therapy. Thus, the 
      contribution of molecular biology and biotechnology to the advances achieved is 
      unquestionable. However, it is still necessary to transcend the boundaries of 
      synthetic chemistry, pharmaco-technics, and pharmacodynamics, aiming to turn 
      promising molecules into newly available drugs for the treatment of fungal 
      diseases.
FAU - Seki Kioshima, Erika
AU  - Seki Kioshima E
AD  - Program in Biosciences and Pathophysiology, Department of Clinical Analysis and 
      Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, 
      Brazil.
FAU - de Souza Bonfim de Mendonca, Patricia
AU  - de Souza Bonfim de Mendonca P
AD  - Program in Biosciences and Pathophysiology, Department of Clinical Analysis and 
      Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, 
      Brazil.
FAU - de Melo Teixeira, Marcus
AU  - de Melo Teixeira M
AUID- ORCID: 0000-0003-1763-3464
AD  - Faculty of Medicine, University of Brasilia (UnB), Brasilia, Distrito Federal 
      70910-900, Brazil.
FAU - Grenier Capoci, Isis Regina
AU  - Grenier Capoci IR
AD  - Program in Biosciences and Pathophysiology, Department of Clinical Analysis and 
      Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, 
      Brazil.
FAU - Amaral, Andre
AU  - Amaral A
AUID- ORCID: 0000-0001-9516-8970
AD  - Institute of Tropical Pathology and Public Health, Federal University of Goias, 
      Goiania 74690-900, Brazil.
FAU - Vilugron Rodrigues-Vendramini, Franciele Abigail
AU  - Vilugron Rodrigues-Vendramini FA
AD  - Program in Biosciences and Pathophysiology, Department of Clinical Analysis and 
      Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, 
      Brazil.
FAU - Lauton Simoes, Bruna
AU  - Lauton Simoes B
AD  - Program in Biosciences and Pathophysiology, Department of Clinical Analysis and 
      Biomedicine, State University of Maringa (UEM), Maringa, Parana 87020-900, 
      Brazil.
FAU - Rodrigues Abadio, Ana Karina
AU  - Rodrigues Abadio AK
AD  - Faculty of Agricultural Social Sciences, Mato Grosso State University, Nova 
      Mutum, Mato Grosso 78450-000, Brazil.
FAU - Fernandes Matos, Larissa
AU  - Fernandes Matos L
AD  - Faculty of Ceilandia, University of Brasilia (UnB), Brasilia, Distrito Federal 
      72220-275, Brazil.
AD  - Program in Microbial Biology, Institute of Biological Sciences, University of 
      Brasilia, Brasilia 70910-900, Brazil.
FAU - Soares Felipe, Maria Sueli
AU  - Soares Felipe MS
AD  - Program of Genomic Sciences and Biotechnology, Catholic University of Brasilia, 
      Brasilia 70790-160, Brazil.
LA  - eng
GR  - 193.001.533/2016 - PRONEX/CNPq/Fundacao de Apoio a Pesquisa do Distrito Federal/
PT  - Journal Article
PT  - Review
DEP - 20210202
PL  - Switzerland
TA  - J Fungi (Basel)
JT  - Journal of fungi (Basel, Switzerland)
JID - 101671827
PMC - PMC7913102
OTO - NOTNLM
OT  - antifungal
OT  - genomic
OT  - new species discovery
OT  - new targets
COIS- The authors declare no conflict of interest.
EDAT- 2021/02/06 06:00
MHDA- 2021/02/06 06:01
PMCR- 2021/02/02
CRDT- 2021/02/05 01:01
PHST- 2020/12/10 00:00 [received]
PHST- 2021/01/19 00:00 [revised]
PHST- 2021/01/26 00:00 [accepted]
PHST- 2021/02/05 01:01 [entrez]
PHST- 2021/02/06 06:00 [pubmed]
PHST- 2021/02/06 06:01 [medline]
PHST- 2021/02/02 00:00 [pmc-release]
AID - jof7020106 [pii]
AID - jof-07-00106 [pii]
AID - 10.3390/jof7020106 [doi]
PST - epublish
SO  - J Fungi (Basel). 2021 Feb 2;7(2):106. doi: 10.3390/jof7020106.