PMID- 33540829
OWN - NLM
STAT- MEDLINE
DCOM- 20211112
LR  - 20211204
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 10
IP  - 2
DP  - 2021 Feb 2
TI  - Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast.
LID - 10.3390/cells10020305 [doi]
LID - 305
AB  - Cells have developed response systems to constantly monitor environmental changes 
      and accordingly adjust growth, differentiation, and cellular stress programs. The 
      evolutionarily conserved, nutrient-responsive, mechanistic target of rapamycin 
      signaling (mTOR) pathway coordinates basic anabolic and catabolic cellular 
      processes such as gene transcription, protein translation, autophagy, and 
      metabolism, and is directly implicated in cellular and organismal aging as well 
      as age-related diseases. mTOR mediates these processes in response to a broad 
      range of inputs such as oxygen, amino acids, hormones, and energy levels, as well 
      as stresses, including DNA damage. Here, we briefly summarize data relating to 
      the interplays of the mTOR pathway with DNA damage response pathways in fission 
      yeast, a favorite model in cell biology, and how these interactions shape cell 
      decisions, growth, and cell-cycle progression. We, especially, comment on the 
      roles of caffeine-mediated DNA-damage override. Understanding the biology of 
      nutrient response, DNA damage and related pharmacological treatments can lead to 
      the design of interventions towards improved cellular and organismal fitness, 
      health, and survival.
FAU - Alao, John-Patrick
AU  - Alao JP
AUID- ORCID: 0000-0002-1728-8560
AD  - ZEAB Therapeutic, University of East London, Stratford Campus, Water Lane, 
      Stratford, London E15 4LZ, UK.
FAU - Legon, Luc
AU  - Legon L
AUID- ORCID: 0000-0001-7489-5781
AD  - School of Health, Sport and Bioscience, University of East London, Stratford 
      Campus, Water Lane, Stratford, London E15 4LZ, UK.
FAU - Rallis, Charalampos
AU  - Rallis C
AUID- ORCID: 0000-0002-4390-0266
AD  - School of Life Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, 
      UK.
LA  - eng
GR  - RGS\R1\201348/Royal Society/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210202
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Gene Expression Regulation, Fungal/*genetics
MH  - Schizosaccharomyces
MH  - Signal Transduction/*genetics
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC7913062
OTO - NOTNLM
OT  - Rad3
OT  - TORC1
OT  - TORC2
OT  - caffeine
OT  - nutrients
OT  - rapamycin
COIS- The authors declare no conflict of interest.
EDAT- 2021/02/06 06:00
MHDA- 2021/11/16 06:00
PMCR- 2021/02/02
CRDT- 2021/02/05 01:01
PHST- 2021/01/09 00:00 [received]
PHST- 2021/01/27 00:00 [revised]
PHST- 2021/01/28 00:00 [accepted]
PHST- 2021/02/05 01:01 [entrez]
PHST- 2021/02/06 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/02/02 00:00 [pmc-release]
AID - cells10020305 [pii]
AID - cells-10-00305 [pii]
AID - 10.3390/cells10020305 [doi]
PST - epublish
SO  - Cells. 2021 Feb 2;10(2):305. doi: 10.3390/cells10020305.