PMID- 33540848
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210316
IS  - 2304-8158 (Print)
IS  - 2304-8158 (Electronic)
IS  - 2304-8158 (Linking)
VI  - 10
IP  - 2
DP  - 2021 Feb 2
TI  - Development and Validation of an Ultra-Performance Liquid Chromatography-Tandem 
      Mass Spectrometry Method to Determine Maduramicin in Crayfish (Procambarus 
      clarkii) and Evaluate Food Safety.
LID - 10.3390/foods10020301 [doi]
LID - 301
AB  - Maduramicin (MAD) is widely introduced into aquatic environments and results in 
      the contamination of fish products. Worryingly, the consumption of 
      MAD-contaminated crayfish (Procambarus clarkii) may induce symptoms of Haff 
      disease. In this study, to monitor this potential contamination and to understand 
      the residue and elimination characteristics of MAD in edible tissues of crayfish, 
      a sensitive and efficient ultra-performance liquid chromatography-tandem mass 
      spectrometry method was developed, validated, and applied. After extraction with 
      acetonitrile and purification by solid-phase extraction column, multiple-reaction 
      monitoring mass spectrometry with positive ionization mode was used to determine 
      MAD's residues. The limits of detection and of quantification were 6 mug.kg(-1) 
      and 20 mug.kg(-1), respectively. The fortified recoveries ranged from 74.2% to 
      110.4%, with relative standard deviation of 1.2% to 10.1%. Furthermore, MAD was 
      completely eliminated after 3 and 5 days from abdominal muscle and hepatopancreas 
      tissues of crayfish, respectively. The maximum residue limits (MRLs) of MAD 
      respectively was 200 mug.kg(-1) in muscle and 600 mug.kg(-1) in the hepatopancreas, 
      and its withdrawal time in both edible tissues was 25.8  degrees C.d. Collectively, the 
      results of this study indicate the proposed method is an efficient tool to 
      evaluate the public health risk associated with crayfish consumption.
FAU - Gao, Xiuge
AU  - Gao X
AD  - Joint International Research Laboratory of Animal Health and Food Safety, College 
      of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 
      210095, China.
AD  - Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, China.
FAU - Teng, Pei
AU  - Teng P
AD  - Joint International Research Laboratory of Animal Health and Food Safety, College 
      of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 
      210095, China.
AD  - Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, China.
FAU - Peng, Lin
AU  - Peng L
AD  - Joint International Research Laboratory of Animal Health and Food Safety, College 
      of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 
      210095, China.
AD  - Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, China.
FAU - Ji, Hui
AU  - Ji H
AD  - Joint International Research Laboratory of Animal Health and Food Safety, College 
      of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 
      210095, China.
AD  - Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, China.
FAU - Qiu, Yawei
AU  - Qiu Y
AD  - Joint International Research Laboratory of Animal Health and Food Safety, College 
      of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 
      210095, China.
AD  - Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, China.
FAU - Liu, Xiaoxiao
AU  - Liu X
AD  - Joint International Research Laboratory of Animal Health and Food Safety, College 
      of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 
      210095, China.
AD  - Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, China.
FAU - Guo, Dawei
AU  - Guo D
AD  - Joint International Research Laboratory of Animal Health and Food Safety, College 
      of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 
      210095, China.
AD  - Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, China.
FAU - Jiang, Shanxiang
AU  - Jiang S
AD  - Joint International Research Laboratory of Animal Health and Food Safety, College 
      of Veterinary Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 
      210095, China.
AD  - Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, China.
LA  - eng
GR  - 31672612/National Natural Science Foundation of China/
GR  - no grant number/project funded by the Priority Academic Program Development of 
      Jiangsu Higher Education Institutions (PAPD)/
PT  - Journal Article
DEP - 20210202
PL  - Switzerland
TA  - Foods
JT  - Foods (Basel, Switzerland)
JID - 101670569
PMC - PMC7913001
OTO - NOTNLM
OT  - Haff disease
OT  - UPLC-MS/MS
OT  - crayfish
OT  - ionophore antibiotic
OT  - maduramicin
OT  - veterinary drug residue
COIS- The authors declare no conflict of interest.
EDAT- 2021/02/06 06:00
MHDA- 2021/02/06 06:01
PMCR- 2021/02/02
CRDT- 2021/02/05 01:01
PHST- 2020/12/21 00:00 [received]
PHST- 2021/01/26 00:00 [revised]
PHST- 2021/01/27 00:00 [accepted]
PHST- 2021/02/05 01:01 [entrez]
PHST- 2021/02/06 06:00 [pubmed]
PHST- 2021/02/06 06:01 [medline]
PHST- 2021/02/02 00:00 [pmc-release]
AID - foods10020301 [pii]
AID - foods-10-00301 [pii]
AID - 10.3390/foods10020301 [doi]
PST - epublish
SO  - Foods. 2021 Feb 2;10(2):301. doi: 10.3390/foods10020301.