PMID- 33542785
OWN - NLM
STAT- MEDLINE
DCOM- 20210902
LR  - 20220420
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2021
DP  - 2021
TI  - Effects of Occupational Exposure to Waste Anesthetic Gas on Oxidative Stress and 
      DNA Damage.
PG  - 8831535
LID - 10.1155/2021/8831535 [doi]
LID - 8831535
AB  - OBJECTIVE: The aim of the study was to investigate the potential effects of waste 
      anesthetic gas (WAG) on oxidative stress, DNA damage, and vital organs. METHODS: 
      A total of 150 members of the staff at a hospital were assigned to an exposure 
      group or control group. The 68 operating room (OR) staff in the exposure group 
      were exposed to WAG, and the 82 non-OR staff in the control group were not 
      exposed to WAG. Air samples were collected in the OR, and the sevoflurane 
      concentrations in the samples were determined. Superoxide dismutase (SOD), 
      glutathione peroxidase (GSH-px), and malondialdehyde (MDA) in plasma from the 
      participants were determined to assess oxidative stress. Western blot analysis 
      was used to detect gammaH(2)AX in peripheral blood to assess DNA damage. 
      Hematopoietic parameters, liver function, kidney function, and changes in 
      electrophysiology were assessed to identify the effects on the vital organs. 
      RESULTS: The mean (+/-standard deviation) sevoflurane concentration in 172 air 
      samples from 22 operating rooms was 1.11 +/- 0.65 ppm. The superoxide dismutase 
      activity and vital organ parameters (lymphocyte, hemoglobin, and total protein 
      concentrations and heart rate) were significantly lower (P < 0.05) in the exposed 
      group than the control group. The malondialdehyde, total bilirubin, and 
      creatinine concentrations and QT and QTc intervals were significantly higher (P < 
      0.05) in the exposed group than the control group. There were no significant 
      differences between the glutathione peroxidase activities and gammaH2AX 
      concentrations for the exposed and control groups. CONCLUSIONS: Long-term 
      occupational exposure to waste anesthetic gas may affect the antioxidant defense 
      system and probably affects vital organ functions to some extent. No correlation 
      between DNA damage and chronic exposure to WAG was observed.
CI  - Copyright (c) 2021 Hai-Xin Hua et al.
FAU - Hua, Hai-Xin
AU  - Hua HX
AUID- ORCID: 0000-0002-5136-0175
AD  - Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, 
      253 Gongye Ave., Guangzhou, China 510282.
FAU - Deng, Hai-Bo
AU  - Deng HB
AUID- ORCID: 0000-0001-9221-4062
AD  - Department of Anesthesiology, Huizhou Third People's Hospital, Guangzhou Medical 
      University, No. 1, Xuebei Street, Huicheng District, Huizhou City, Guangdong 
      Province, China.
FAU - Huang, Xiu-Ling
AU  - Huang XL
AUID- ORCID: 0000-0003-1038-256X
AD  - Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, 
      253 Gongye Ave., Guangzhou, China 510282.
FAU - Ma, Chang-Qing
AU  - Ma CQ
AUID- ORCID: 0000-0001-9864-7387
AD  - Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, 
      253 Gongye Ave., Guangzhou, China 510282.
FAU - Xu, Ping
AU  - Xu P
AUID- ORCID: 0000-0001-7767-4474
AD  - Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, 
      253 Gongye Ave., Guangzhou, China 510282.
FAU - Cai, Ye-Hua
AU  - Cai YH
AUID- ORCID: 0000-0001-8855-0346
AD  - Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, 
      253 Gongye Ave., Guangzhou, China 510282.
FAU - Wang, Hai-Tang
AU  - Wang HT
AUID- ORCID: 0000-0001-6555-1020
AD  - Department of Anesthesiology, Nanfang Hospital of Southern Medical University, 
      1838 Guangzhoudadaobei, Guangzhou, China 510515.
LA  - eng
PT  - Journal Article
DEP - 20210119
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Air Pollutants)
RN  - 0 (Anesthetics)
RN  - 0 (Gases)
RN  - 0 (Medical Waste)
RN  - 38LVP0K73A (Sevoflurane)
SB  - IM
MH  - Adult
MH  - Air Pollutants/adverse effects/analysis
MH  - Anesthetics/*adverse effects/analysis
MH  - Case-Control Studies
MH  - China
MH  - Cross-Sectional Studies
MH  - DNA Damage
MH  - Female
MH  - Gases
MH  - Humans
MH  - Inhalation Exposure/adverse effects/analysis
MH  - Male
MH  - Medical Waste/adverse effects
MH  - Middle Aged
MH  - Occupational Exposure/*adverse effects/analysis
MH  - Operating Rooms
MH  - Organs at Risk/physiology
MH  - Oxidative Stress/*drug effects/genetics
MH  - Sevoflurane/adverse effects
MH  - Young Adult
PMC - PMC7840251
COIS- The authors declare no competing financial interests.
EDAT- 2021/02/06 06:00
MHDA- 2021/09/03 06:00
PMCR- 2021/01/19
CRDT- 2021/02/05 05:59
PHST- 2020/08/06 00:00 [received]
PHST- 2020/10/27 00:00 [revised]
PHST- 2021/01/08 00:00 [accepted]
PHST- 2021/02/05 05:59 [entrez]
PHST- 2021/02/06 06:00 [pubmed]
PHST- 2021/09/03 06:00 [medline]
PHST- 2021/01/19 00:00 [pmc-release]
AID - 10.1155/2021/8831535 [doi]
PST - epublish
SO  - Oxid Med Cell Longev. 2021 Jan 19;2021:8831535. doi: 10.1155/2021/8831535. 
      eCollection 2021.