PMID- 33543453
OWN - NLM
STAT- MEDLINE
DCOM- 20210215
LR  - 20210215
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1295
DP  - 2021
TI  - Conventional Nanosized Drug Delivery Systems for Cancer Applications.
PG  - 3-27
LID - 10.1007/978-3-030-58174-9_1 [doi]
AB  - Clinical responses and tolerability of conventional nanocarriers (NCs) are 
      sometimes different from those expected in anticancer therapy. Thus, new smart 
      drug delivery systems (DDSs) with stimuli-responsive properties and novel 
      materials have been developed. Several clinical trials demonstrated that these 
      DDSs have better clinical therapeutic efficacy in the treatment of many cancers 
      than free drugs. Composition of DDSs and their surface properties increase the 
      specific targeting of therapeutics versus cancer cells, without affecting healthy 
      tissues, and thus limiting their toxicity versus unspecific tissues. Herein, an 
      extensive revision of literature on NCs used as DDSs for cancer applications has 
      been performed using the available bibliographic databases.
FAU - Vergallo, Cristian
AU  - Vergallo C
AD  - Department of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti, 
      Italy.
FAU - Hafeez, Muhammad Nadeem
AU  - Hafeez MN
AD  - Department of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti, 
      Italy.
FAU - Iannotta, Dalila
AU  - Iannotta D
AD  - Department of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti, 
      Italy.
FAU - Santos, Helder A
AU  - Santos HA
AD  - Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
FAU - D'Avanzo, Nicola
AU  - D'Avanzo N
AD  - Department of Health Sciences, University of Catanzaro "Magna Graecia", 
      Catanzaro, Italy.
FAU - Dini, Luciana
AU  - Dini L
AD  - Department of Biology and Biotechnology "Charles Darwin", University of Rome 
      "Sapienza", Rome, Italy.
AD  - CNR Nanotec, Lecce, Italy.
FAU - Cilurzo, Felisa
AU  - Cilurzo F
AD  - Department of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti, 
      Italy.
FAU - Fresta, Massimo
AU  - Fresta M
AD  - Department of Health Sciences, University of Catanzaro "Magna Graecia", 
      Catanzaro, Italy.
FAU - Di Marzio, Luisa
AU  - Di Marzio L
AD  - Department of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti, 
      Italy.
FAU - Christian, Celia
AU  - Christian C
AD  - Department of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti, 
      Italy. c.celia@unich.it.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Drug Carriers)
SB  - IM
MH  - Drug Carriers/therapeutic use
MH  - Drug Delivery Systems
MH  - Humans
MH  - *Nanoparticles
MH  - *Neoplasms/drug therapy
OTO - NOTNLM
OT  - Active targeting
OT  - Anticancer therapy
OT  - Aptamers
OT  - Carbon nanostructure
OT  - Colloidal nanoparticles
OT  - Dendrimers
OT  - Drug delivery systems
OT  - Hyper-branched polymers
OT  - Lipid nanoparticles
OT  - Liposomes
OT  - Metallic nanoparticles
OT  - Nanocrystal
OT  - Passive targeting
OT  - Polymeric nanoparticles
OT  - Therapeutic proteins
EDAT- 2021/02/06 06:00
MHDA- 2021/02/16 06:00
CRDT- 2021/02/05 06:05
PHST- 2021/02/05 06:05 [entrez]
PHST- 2021/02/06 06:00 [pubmed]
PHST- 2021/02/16 06:00 [medline]
AID - 10.1007/978-3-030-58174-9_1 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2021;1295:3-27. doi: 10.1007/978-3-030-58174-9_1.