PMID- 33543544
OWN - NLM
STAT- MEDLINE
DCOM- 20210903
LR  - 20210904
IS  - 1442-200X (Electronic)
IS  - 1328-8067 (Linking)
VI  - 63
IP  - 9
DP  - 2021 Sep
TI  - Association between preterm birth and maternal allergy considering IgE level.
PG  - 1026-1032
LID - 10.1111/ped.14635 [doi]
AB  - BACKGROUND: The aim of this study was to explore the association between maternal 
      allergies and preterm birth by different total immunoglobulin E (IgE) levels. 
      METHODS: Data of 81 791 pregnant women from the Japan Environment and Children's 
      Study, a prospective birth cohort, were used. Maternal allergic diseases, 
      including a history of bronchial asthma (BA), atopic dermatitis (AD), and 
      allergic rhinitis (AR), were obtained by self-administered questionnaires. Total 
      serum IgE levels were measured at the first trimester and obstetrical outcomes 
      from medical records transcripts were analyzed. The association between maternal 
      allergic disease and obstetric outcome, including threatened abortion, preterm 
      labor, early preterm birth (22-33 weeks), and late preterm birth (34-36 weeks), 
      were examined by logistic regression. Subgroup analyses were performed by IgE 
      level. RESULTS: Maternal BA and AR were associated with an increased risk of 
      threatened abortion and preterm labor, but high total IgE level was associated 
      with a decreased risk of preterm labor. There was little difference in 
      associations between allergic disease and threatened abortion and preterm labor 
      by total IgE levels. Although there was no significant association between 
      allergic disease and preterm birth, if total IgE was high, AR was significantly 
      associated with a decreased risk of early preterm birth (adjusted odds ratio, 
      0.60; 95% confidence interval 0.43-0.86). There was significant evidence for 
      differences associated with total IgE levels (P-values for the interaction of the 
      effects of AD and AR on early preterm birth were 0.039 and 0.015, respectively). 
      CONCLUSIONS: The effect of allergy on preterm birth might differ depending on the 
      total IgE level.
CI  - (c) 2021 Japan Pediatric Society.
FAU - Kojima, Reiji
AU  - Kojima R
AUID- ORCID: 0000-0002-9712-889X
AD  - Department of Health Sciences, School of Medicine, University of Yamanashi, 
      Yamanashi, Japan.
FAU - Yokomichi, Hiroshi
AU  - Yokomichi H
AUID- ORCID: 0000-0001-7369-155X
AD  - Department of Health Sciences, School of Medicine, University of Yamanashi, 
      Yamanashi, Japan.
FAU - Akiyama, Yuka
AU  - Akiyama Y
AD  - Department of Health Sciences, School of Medicine, University of Yamanashi, 
      Yamanashi, Japan.
FAU - Ooka, Tadao
AU  - Ooka T
AD  - Department of Health Sciences, School of Medicine, University of Yamanashi, 
      Yamanashi, Japan.
FAU - Miyake, Kunio
AU  - Miyake K
AD  - Department of Health Sciences, School of Medicine, University of Yamanashi, 
      Yamanashi, Japan.
FAU - Horiuchi, Sayaka
AU  - Horiuchi S
AD  - Center for Birth Cohort Studies, University of Yamanashi, Yamanashi, Japan.
FAU - Shinohara, Ryoji
AU  - Shinohara R
AD  - Center for Birth Cohort Studies, University of Yamanashi, Yamanashi, Japan.
FAU - Yamagata, Zentaro
AU  - Yamagata Z
AD  - Department of Health Sciences, School of Medicine, University of Yamanashi, 
      Yamanashi, Japan.
AD  - Center for Birth Cohort Studies, University of Yamanashi, Yamanashi, Japan.
CN  - Japan Environment and Children's Study Group
LA  - eng
GR  - Ministry of the Environment, Japan./
GR  - Ministry of the Environment, Japan/
PT  - Journal Article
DEP - 20210714
PL  - Australia
TA  - Pediatr Int
JT  - Pediatrics international : official journal of the Japan Pediatric Society
JID - 100886002
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
DRIN- Pediatr Int. 2021 Sep;63(9):1005. PMID: 34472647
MH  - Child
MH  - *Dermatitis, Atopic/epidemiology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E
MH  - Infant, Newborn
MH  - Pregnancy
MH  - *Premature Birth/epidemiology
MH  - Prospective Studies
MH  - *Rhinitis, Allergic
OTO - NOTNLM
OT  - allergic diseases
OT  - immunoglobulin E
OT  - preterm birth
OT  - preterm labor
OT  - threatened abortion
FIR - Kamijima, Michihiro
IR  - Kamijima M
FIR - Yamazaki, Shin
IR  - Yamazaki S
FIR - Ohya, Yukihiro
IR  - Ohya Y
FIR - Kishi, Reiko
IR  - Kishi R
FIR - Yaegashi, Nobuo
IR  - Yaegashi N
FIR - Hashimoto, Koichi
IR  - Hashimoto K
FIR - Mori, Chisato
IR  - Mori C
FIR - Ito, Shuichi
IR  - Ito S
FIR - Yamagata, Zentaro
IR  - Yamagata Z
FIR - Inadera, Hidekuni
IR  - Inadera H
FIR - Nakayama, Takeo
IR  - Nakayama T
FIR - Iso, Hiroyasu
IR  - Iso H
FIR - Shima, Masayuki
IR  - Shima M
FIR - Kurozawa, Youichi
IR  - Kurozawa Y
FIR - Suganuma, Narufumi
IR  - Suganuma N
FIR - Kusuhara, Koichi
IR  - Kusuhara K
FIR - Katoh, Takahiko
IR  - Katoh T
EDAT- 2021/02/06 06:00
MHDA- 2021/09/04 06:00
CRDT- 2021/02/05 06:07
PHST- 2020/12/29 00:00 [revised]
PHST- 2020/07/27 00:00 [received]
PHST- 2021/02/01 00:00 [accepted]
PHST- 2021/02/06 06:00 [pubmed]
PHST- 2021/09/04 06:00 [medline]
PHST- 2021/02/05 06:07 [entrez]
AID - 10.1111/ped.14635 [doi]
PST - ppublish
SO  - Pediatr Int. 2021 Sep;63(9):1026-1032. doi: 10.1111/ped.14635. Epub 2021 Jul 14.