PMID- 33543580
OWN - NLM
STAT- MEDLINE
DCOM- 20210630
LR  - 20210630
IS  - 2162-3279 (Electronic)
VI  - 11
IP  - 4
DP  - 2021 Apr
TI  - Seizures as onset symptoms and rapid course in preschool children with subacute 
      sclerosing panencephalitis.
PG  - e02051
LID - 10.1002/brb3.2051 [doi]
LID - e02051
AB  - BACKGROUND: The clinical features and outcomes of subacute sclerosing 
      panencephalitis (SSPE) in younger children are different from those of adults, 
      leading easily to misdiagnosis during the early stage. So far, there are limited 
      data related to SSPE in preschool children. METHODS: In order to summarize the 
      clinical data and evolution of SSPE in preschool children and to expand the 
      phenotypes of SSPE, the medical charts of preschool patients diagnosed with SSPE 
      were retrospectively reviewed and analyzed; the clinical outcomes of the enrolled 
      cases were evaluated and followed up. RESULTS: Overall, we included three cases 
      in the study. Their onset age was 5 years and 2 months, 4 years and 3 months, and 
      4 years and 2 months, respectively. All patients presented drop attacks or jerks 
      as the onset symptom, and one patient had concurrent gait disturbance. Atypical 
      periodic complexes on electroencephalography (EEG) were recorded in all patients. 
      The brain magnetic resonance imaging (MRI) findings of two cases showed 
      demyelinating lesions predominantly on the white matter. The neurological 
      conditions of all cases deteriorated rapidly. Two children died at 21 months and 
      6 months after onset, respectively. The other case progressively developed 
      vegetative status and akinetic mutism within 4 months. CONCLUSIONS: In younger 
      children, the characteristic features of SSPE may be seizures and gait 
      instability as onset manifestations, atypical periodic complexes on EEG, and 
      rapid worsening of neurological conditions.
CI  - (c) 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
FAU - Liao, Shuang
AU  - Liao S
AD  - Department of Neurology, Children's Hospital of Chongqing Medical University, 
      Ministry of Education Key Laboratory of Child Development and Disorders, National 
      Clinical Research Center for Child Health and Disorders (Chongqing), 
      International Science and Technology Cooperation Base of Child Development and 
      Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
FAU - Zhong, Min
AU  - Zhong M
AD  - Department of Neurology, Children's Hospital of Chongqing Medical University, 
      Ministry of Education Key Laboratory of Child Development and Disorders, National 
      Clinical Research Center for Child Health and Disorders (Chongqing), 
      International Science and Technology Cooperation Base of Child Development and 
      Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
FAU - Zou, Nan
AU  - Zou N
AD  - Department of Neurology, Children's Hospital of Chongqing Medical University, 
      Ministry of Education Key Laboratory of Child Development and Disorders, National 
      Clinical Research Center for Child Health and Disorders (Chongqing), 
      International Science and Technology Cooperation Base of Child Development and 
      Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
FAU - Li, Tingsong
AU  - Li T
AUID- ORCID: 0000-0003-4536-3211
AD  - Department of Neurology, Children's Hospital of Chongqing Medical University, 
      Ministry of Education Key Laboratory of Child Development and Disorders, National 
      Clinical Research Center for Child Health and Disorders (Chongqing), 
      International Science and Technology Cooperation Base of Child Development and 
      Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
FAU - Jiang, Li
AU  - Jiang L
AD  - Department of Neurology, Children's Hospital of Chongqing Medical University, 
      Ministry of Education Key Laboratory of Child Development and Disorders, National 
      Clinical Research Center for Child Health and Disorders (Chongqing), 
      International Science and Technology Cooperation Base of Child Development and 
      Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20210205
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
SB  - IM
MH  - Child, Preschool
MH  - Electroencephalography
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Retrospective Studies
MH  - Seizures
MH  - *Subacute Sclerosing Panencephalitis/diagnosis/diagnostic imaging
PMC - PMC8035432
OTO - NOTNLM
OT  - children
OT  - clinical manifestation
OT  - prognosis
OT  - subacute sclerosing panencephalitis
COIS- The authors declare that they have no competing interests.
EDAT- 2021/02/06 06:00
MHDA- 2021/07/01 06:00
PMCR- 2021/02/05
CRDT- 2021/02/05 06:07
PHST- 2021/01/14 00:00 [revised]
PHST- 2020/09/03 00:00 [received]
PHST- 2021/01/18 00:00 [accepted]
PHST- 2021/02/06 06:00 [pubmed]
PHST- 2021/07/01 06:00 [medline]
PHST- 2021/02/05 06:07 [entrez]
PHST- 2021/02/05 00:00 [pmc-release]
AID - BRB32051 [pii]
AID - 10.1002/brb3.2051 [doi]
PST - ppublish
SO  - Brain Behav. 2021 Apr;11(4):e02051. doi: 10.1002/brb3.2051. Epub 2021 Feb 5.