PMID- 33543662
OWN - NLM
STAT- MEDLINE
DCOM- 20211213
LR  - 20211214
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 29
IP  - 5
DP  - 2021 Aug
TI  - Cytokeratin 7, GATA3, and SOX-10 is a Comprehensive Panel in Diagnosing Triple 
      Negative Breast Cancer Brain Metastases.
PG  - 470-474
LID - 10.1177/1066896921990717 [doi]
AB  - Following lung cancer, breast cancer is the second most common metastatic tumor 
      to the brain, of which triple-negative breast cancer (TNBC) and human epidermal 
      growth factor receptor 2+ (HER2+) breast cancer are the most common subtypes. 
      TNBC does not have standard immunoprofiles and can be difficult to distinguish 
      from other metastases. A tissue microarray was created from 47 patients with 
      breast cancer metastases to the brain and 12 paired breast primaries. Of 47 
      breast cancer metastases, 24 were HER2+, 14 were TNBC, and 9 were luminal. 
      Forty-five were cytokeratin 7 (CK7) positive, 36 were GATA-binding protein 3 
      (GATA3) positive, 7 were Sry-related HMg-Box gene 10 (SOX-10) positive, 20 were 
      mammaglobin positive, and 19 were gross cystic disease fluid protein 15 positive. 
      At least one of the CK7, GATA3, or SOX-10 was positive in all TNBC metastases. A 
      panel of CK7, GATA3, and SOX-10 is complementary in the diagnosis of breast 
      cancer brain metastasis. SOX-10 appears to be a specific but not particularly 
      sensitive marker in this context.
FAU - Statz, Eric
AU  - Statz E
AD  - 5506Medical College of Wisconsin, Milwaukee, WI, USA.
FAU - Jorns, Julie M
AU  - Jorns JM
AUID- ORCID: 0000-0002-7777-6670
AD  - 5506Medical College of Wisconsin, Milwaukee, WI, USA.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210205
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
RN  - 0 (KRT7 protein, human)
RN  - 0 (Keratin-7)
RN  - 0 (SOX10 protein, human)
RN  - 0 (SOXE Transcription Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*analysis/metabolism
MH  - Brain Neoplasms/*diagnosis/secondary
MH  - Case-Control Studies
MH  - Feasibility Studies
MH  - Female
MH  - GATA3 Transcription Factor/analysis/metabolism
MH  - Humans
MH  - Keratin-7/analysis/metabolism
MH  - Middle Aged
MH  - SOXE Transcription Factors/*analysis/metabolism
MH  - Sensitivity and Specificity
MH  - Tissue Array Analysis
MH  - Triple Negative Breast Neoplasms/*pathology
MH  - Young Adult
OTO - NOTNLM
OT  - GATA3
OT  - SOX-10
OT  - brain metastasis
OT  - breast cancer
OT  - immunohistochemistry
EDAT- 2021/02/06 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/02/05 08:37
PHST- 2021/02/06 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/02/05 08:37 [entrez]
AID - 10.1177/1066896921990717 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2021 Aug;29(5):470-474. doi: 10.1177/1066896921990717. Epub 
      2021 Feb 5.