PMID- 33545836
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 120
DP  - 2021 Jan
TI  - Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing 
      of diabetic rats by promoting angiogenesis.
PG  - 111671
LID - S0928-4931(20)33589-X [pii]
LID - 10.1016/j.msec.2020.111671 [doi]
AB  - Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) were 
      helpful for injury repair, but whether HUCMSCs-derived exosomes could be 
      encapsulated in a novel nanohydrogel to regulate diabetic wound healing was 
      unclear. Here, HUCMSCs-derived exosomes encapsulated in a bioactive scaffold 
      composed of polyvinyl alcohol (PVA)/alginate (Alg) nanohydrogel (exo@H) was 
      applied to wound healing of diabetic rats. Results found that exo@H could 
      facilitate the proliferation, migration and angiogenesis of HUVECs and sped up 
      the process of diabetic wound healing. We confirmed that exo@H contributed to the 
      expression of the molecules related to wound healing, including SMA, SR-B1 and 
      CD31. Besides, we also found that exo@H up-regulated VEGF level via regulating 
      ERK1/2 pathway. These data demonstrated that exo@H significantly accelerated 
      healing of diabetic wounds in rats by promoting angiogenesis.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Zhang, Yiyao
AU  - Zhang Y
AD  - Jinzhou Medical University, Jinzhou 121001, People's Republic of China.
FAU - Zhang, Peng
AU  - Zhang P
AD  - Jinzhou Medical University, Jinzhou 121001, People's Republic of China.
FAU - Gao, Xiuqiu
AU  - Gao X
AD  - Jinzhou Medical University, Jinzhou 121001, People's Republic of China. 
      Electronic address: jzgaoxiuqiu1988@163.com.
FAU - Chang, Linna
AU  - Chang L
AD  - Jinzhou Medical University, Jinzhou 121001, People's Republic of China.
FAU - Chen, Zhenhua
AU  - Chen Z
AD  - Jinzhou Medical University, Jinzhou 121001, People's Republic of China. 
      Electronic address: zhchen561@yahoo.com.
FAU - Mei, Xifan
AU  - Mei X
AD  - Jinzhou Medical University, Jinzhou 121001, People's Republic of China. 
      Electronic address: meixifan1971@163.com.
LA  - eng
PT  - Journal Article
DEP - 20201022
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Animals
MH  - *Diabetes Mellitus, Experimental/therapy
MH  - *Exosomes
MH  - *Mesenchymal Stem Cells
MH  - Rats
MH  - Vascular Endothelial Growth Factor A
MH  - Wound Healing
OTO - NOTNLM
OT  - Alginate
OT  - Angiogenesis
OT  - Diabetic wound healing
OT  - Exosomes
OT  - Nanohydrogel
OT  - PVA
EDAT- 2021/02/07 06:00
MHDA- 2021/05/15 06:00
CRDT- 2021/02/06 01:00
PHST- 2020/06/20 00:00 [received]
PHST- 2020/10/09 00:00 [revised]
PHST- 2020/10/20 00:00 [accepted]
PHST- 2021/02/06 01:00 [entrez]
PHST- 2021/02/07 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
AID - S0928-4931(20)33589-X [pii]
AID - 10.1016/j.msec.2020.111671 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2021 Jan;120:111671. doi: 
      10.1016/j.msec.2020.111671. Epub 2020 Oct 22.