PMID- 33546254
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210316
IS  - 2079-4991 (Print)
IS  - 2079-4991 (Electronic)
IS  - 2079-4991 (Linking)
VI  - 11
IP  - 2
DP  - 2021 Feb 3
TI  - Bioactive Icariin/beta-CD-IC/Bacterial Cellulose with Enhanced Biomedical Potential.
LID - 10.3390/nano11020387 [doi]
LID - 387
AB  - A "super" bioactive antibacterial hydrogel, Icariin-beta-CD-inclusion 
      complex/Bacterial cellulose and an equally capable counterpart Icariin-Bacterial 
      cellulose (ICBC) were successfully produced with excellent antioxidant 
      properties. The highly porous hydrogels demonstrated very high fluid/liquid 
      absorption capability and were functionally active as Fourier Transform Infrared 
      Spectrometer (FTIR) test confirmed the existence of abundant hydroxyls (-OH 
      stretching), carboxylic acids (-CH(2)/C-O stretching), Alkyne/nitrile (C identical withC/C identical withN 
      stretching with triple bonds) and phenol (C-H/N-O symmetric stretching) 
      functional groups. Scanning electron microscope (SEM) and X-ray diffraction (XRD) 
      tests confirmed a successful beta-CD-inclusion complexation with Icariin with a 
      great potential for sustained and controlled drug release. In vitro drug release 
      test results indicated a systemic and controlled release of the drug (Icariin) 
      from the internal cavities of the beta-CD inclusion complex incorporated inside the 
      BC matrix with high Icariin (drug) release rates. Impressive inactivation rates 
      against Gram-negative bacteria Escherichia coli ATCC 8099 and gram-positive 
      bacteria Staphylococcus aureus ATCC 6538; >99.19% and >98.89% respectively were 
      recorded, as the materials proved to be non-toxic on L929 cells in the in vitro 
      cytotoxicity test results. The materials with promising versatile multipurpose 
      administration of Icariin for wound dressing (as wound dressers), can also be 
      executed as implants for tissue regeneration, as well as face-mask for cosmetic 
      purposes.
FAU - Mensah, Alfred
AU  - Mensah A
AD  - Key Laboratory of Eco-Textiles, Ministry of Education, College of Textile and 
      Clothing, Jiangnan University, Wuxi 214122, China.
FAU - Chen, Yajun
AU  - Chen Y
AD  - Key Laboratory of Eco-Textiles, Ministry of Education, College of Textile and 
      Clothing, Jiangnan University, Wuxi 214122, China.
FAU - Asinyo, Benjamin K
AU  - Asinyo BK
AD  - Department of Industrial Art, Kwame Nkrumah University of Science and Technology, 
      Kumasi 00233, Ghana.
FAU - Howard, Ebenezer Kofi
AU  - Howard EK
AD  - Department of Industrial Art, Kwame Nkrumah University of Science and Technology, 
      Kumasi 00233, Ghana.
FAU - Narh, Christopher
AU  - Narh C
AD  - Key Laboratory of Eco-Textiles, Ministry of Education, College of Textile and 
      Clothing, Jiangnan University, Wuxi 214122, China.
FAU - Huang, Jieyu
AU  - Huang J
AD  - Key Laboratory of Eco-Textiles, Ministry of Education, College of Textile and 
      Clothing, Jiangnan University, Wuxi 214122, China.
FAU - Wei, Qufu
AU  - Wei Q
AD  - Key Laboratory of Eco-Textiles, Ministry of Education, College of Textile and 
      Clothing, Jiangnan University, Wuxi 214122, China.
LA  - eng
GR  - BK20180628/Natural Science Foundation of Jiangsu Province/
GR  - 51803078/National Science Foundation of China/
GR  - JUSRP11701/Fundamental Research Funds for the Central Universities/
GR  - n/a/Priority Academic Program Development of Jiangsu Higher Education 
      Institutions/
GR  - PPZY2015B147/Top-notch Academics Programs Project of Jiangsu Higher Education 
      Institutions/
PT  - Journal Article
DEP - 20210203
PL  - Switzerland
TA  - Nanomaterials (Basel)
JT  - Nanomaterials (Basel, Switzerland)
JID - 101610216
PMC - PMC7913306
OTO - NOTNLM
OT  - Icariin-beta-CD inclusion complex
OT  - antibacterial
OT  - antioxidants
OT  - bacterial cellulose
OT  - biomedical applications
OT  - controlled-drug release
COIS- The authors declare no conflict of interest.
EDAT- 2021/02/07 06:00
MHDA- 2021/02/07 06:01
PMCR- 2021/02/03
CRDT- 2021/02/06 01:02
PHST- 2020/12/28 00:00 [received]
PHST- 2021/01/27 00:00 [revised]
PHST- 2021/01/27 00:00 [accepted]
PHST- 2021/02/06 01:02 [entrez]
PHST- 2021/02/07 06:00 [pubmed]
PHST- 2021/02/07 06:01 [medline]
PHST- 2021/02/03 00:00 [pmc-release]
AID - nano11020387 [pii]
AID - nanomaterials-11-00387 [pii]
AID - 10.3390/nano11020387 [doi]
PST - epublish
SO  - Nanomaterials (Basel). 2021 Feb 3;11(2):387. doi: 10.3390/nano11020387.