PMID- 33546628
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20210419
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Feb 5
TI  - Abnormal regional homogeneity and its relationship with symptom severity in 
      cervical dystonia: a rest state fMRI study.
PG  - 55
LID - 10.1186/s12883-021-02079-x [doi]
LID - 55
AB  - BACKGROUND: Although several brain networks play important roles in cervical 
      dystonia (CD) patients, regional homogeneity (ReHo) changes in CD patients have 
      not been clarified. We investigated to explore ReHo in CD patients at rest and 
      analyzed its correlations with symptom severity as measured by Tsui scale. 
      METHODS: A total of 19 CD patients and 21 gender-, age-, and education-matched 
      healthy controls underwent fMRI scans at rest state. Data were analyzed by ReHo 
      method. RESULTS: Patients showed increased ReHo in the right cerebellum crus I 
      and decreased ReHo in the right superior medial prefrontal cortex (MPFC). 
      Moreover, the right precentral gyrus, right insula, and bilateral middle 
      cingulate gyrus also showed increased ReHo values. A significantly positive 
      correlation was observed between ReHo value in the right cerebellum crus I and 
      symptom severity (p < 0.05). CONCLUSIONS: Our investigation suggested abnormal 
      ReHo existed in brain regions of the "pain matrix" and salience network (the 
      right insula and bilateral middle cingulate gyrus), the motor network (the right 
      precentral gyrus), the cerebellum and MPFC and further highlighted the 
      significance of these networks in the pathology of CD.
FAU - Wei, Shubao
AU  - Wei S
AD  - Department of Rehabilitation Medicine, Jiangbin Hospital of Guangxi Zhuang 
      Autonomous Region, Nanning, 530021, Guangxi, China.
FAU - Lu, Chunhui
AU  - Lu C
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, 530021, Guangxi, China.
FAU - Chen, Xiuqiong
AU  - Chen X
AD  - Department of Rehabilitation Medicine, Jiangbin Hospital of Guangxi Zhuang 
      Autonomous Region, Nanning, 530021, Guangxi, China.
FAU - Yang, Lu
AU  - Yang L
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, 530021, Guangxi, China.
FAU - Wei, Jing
AU  - Wei J
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, 530021, Guangxi, China.
FAU - Jiang, Wenyan
AU  - Jiang W
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, 530021, Guangxi, China.
FAU - Liu, Yang
AU  - Liu Y
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, 530021, Guangxi, China.
FAU - Li, Hui Hui
AU  - Li HH
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, 530021, Guangxi, China.
FAU - Qin, Yuhong
AU  - Qin Y
AD  - Department of Radiology, the First Affiliated Hospital, Guangxi Medical 
      University, Nanning, 530021, Guangxi, China.
FAU - Lei, Yiwu
AU  - Lei Y
AD  - Department of Radiology, the First Affiliated Hospital, Guangxi Medical 
      University, Nanning, 530021, Guangxi, China.
FAU - Qin, Chao
AU  - Qin C
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, 530021, Guangxi, China.
FAU - Hu, Caiyou
AU  - Hu C
AD  - Department of Rehabilitation Medicine, Jiangbin Hospital of Guangxi Zhuang 
      Autonomous Region, Nanning, 530021, Guangxi, China. cyhu.hua@163.com.
FAU - Luo, Shuguang
AU  - Luo S
AUID- ORCID: 0000-0002-4082-6136
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, 530021, Guangxi, China. luoshuguang@stu.gxmu.edu.cn.
LA  - eng
GR  - S201415-05/Guangxi Appropriate Technology for Medical and Health Research and 
      Development Project/
GR  - 81460203/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20210205
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
SB  - IM
MH  - Adult
MH  - Brain/*diagnostic imaging/*pathology
MH  - Brain Mapping/methods
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Torticollis/*diagnostic imaging/*pathology
PMC - PMC7863325
OTO - NOTNLM
OT  - Cervical dystonia
OT  - Default mode network
OT  - Regional homogeneity
OT  - Resting-state functional magnetic resonance
COIS- None.
EDAT- 2021/02/07 06:00
MHDA- 2021/04/20 06:00
PMCR- 2021/02/05
CRDT- 2021/02/06 05:27
PHST- 2020/07/02 00:00 [received]
PHST- 2021/01/26 00:00 [accepted]
PHST- 2021/02/06 05:27 [entrez]
PHST- 2021/02/07 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2021/02/05 00:00 [pmc-release]
AID - 10.1186/s12883-021-02079-x [pii]
AID - 2079 [pii]
AID - 10.1186/s12883-021-02079-x [doi]
PST - epublish
SO  - BMC Neurol. 2021 Feb 5;21(1):55. doi: 10.1186/s12883-021-02079-x.