PMID- 33548380
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 330
DP  - 2021 May 1
TI  - Post-prandial effects of high-polyphenolic extra virgin olive oil on endothelial 
      function in adults at risk for type 2 diabetes: A randomized controlled crossover 
      trial.
PG  - 171-176
LID - S0167-5273(21)00144-3 [pii]
LID - 10.1016/j.ijcard.2021.01.062 [doi]
AB  - BACKGROUND: Effects of olive oil on cardiovascular risk have been controversial. 
      We compared the effects of high-polyphenolic extra virgin olive oil (EVOO) and 
      refined olive oil without polyphenols on endothelial function (EF) in adults at 
      risk for Type 2 diabetes mellitus (T2DM). METHODS: Randomized, controlled, 
      double-blind, crossover trial of 20 adults (mean age 56.1 years; 10 women, 10 
      men) at risk for T2DM (i.e., as defined by either prediabetes or metabolic 
      syndrome) assigned to one of two possible sequence permutations of two different 
      single dose treatments (50 mL of high-polyphenolic EVOO or 50 mL of refined olive 
      oil without polyphenols), with 1-week washout. Participants received their olive 
      oils in a smoothie consisting of (1/2) cup frozen blueberries and 1 cup (8 oz) 
      low-fat vanilla yogurt blended together. Primary outcome measure was EF measured 
      as flow-mediated dilatation. Participants were evaluated before and 2 h after 
      ingestion of their assigned olive oil treatment. RESULTS: EVOO acutely improved 
      EF as compared to refined olive oil (1.2 +/- 6.5% versus -3.6 +/- 3.8%; p = 0.0086). 
      No significant effects on systolic or diastolic blood pressure were observed. 
      CONCLUSIONS: High-polyphenolic EVOO acutely enhanced EF in the study cohort, 
      whereas refined olive oil did not. Blood pressure effects were not observed. 
      Reports on the vascular effects of olive oil ingestion should specify the 
      characteristics of the oil. CLINICAL TRIAL REGISTRATION NUMBER: NCT04025281.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Njike, Valentine Y
AU  - Njike VY
AD  - Yale-Griffin Prevention Research Center, United States of America; Griffin 
      Hospital, Derby, CT (VN, RA, JT, KD, DK), United States of America. Electronic 
      address: valentine.njike@yalegriffinprc.org.
FAU - Ayettey, Rockiy
AU  - Ayettey R
AD  - Yale-Griffin Prevention Research Center, United States of America; Griffin 
      Hospital, Derby, CT (VN, RA, JT, KD, DK), United States of America. Electronic 
      address: rockiy.ayettey@yalegriffinprc.org.
FAU - Treu, Judith A
AU  - Treu JA
AD  - Yale-Griffin Prevention Research Center, United States of America; Griffin 
      Hospital, Derby, CT (VN, RA, JT, KD, DK), United States of America.
FAU - Doughty, Kimberly N
AU  - Doughty KN
AD  - Yale-Griffin Prevention Research Center, United States of America; Griffin 
      Hospital, Derby, CT (VN, RA, JT, KD, DK), United States of America.
FAU - Katz, David L
AU  - Katz DL
AD  - Yale-Griffin Prevention Research Center, United States of America.
LA  - eng
SI  - ClinicalTrials.gov/NCT04025281
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20210203
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Olive Oil)
SB  - IM
MH  - Adult
MH  - Cross-Over Studies
MH  - *Diabetes Mellitus, Type 2/diagnosis/drug therapy/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Metabolic Syndrome
MH  - Middle Aged
MH  - Olive Oil
MH  - Postprandial Period
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Endothelial function
OT  - Olive oil
COIS- Declaration of Competing Interest No competing conflict of interest to disclose.
EDAT- 2021/02/07 06:00
MHDA- 2021/05/29 06:00
CRDT- 2021/02/06 20:10
PHST- 2020/01/22 00:00 [received]
PHST- 2021/01/19 00:00 [revised]
PHST- 2021/01/25 00:00 [accepted]
PHST- 2021/02/07 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
PHST- 2021/02/06 20:10 [entrez]
AID - S0167-5273(21)00144-3 [pii]
AID - 10.1016/j.ijcard.2021.01.062 [doi]
PST - ppublish
SO  - Int J Cardiol. 2021 May 1;330:171-176. doi: 10.1016/j.ijcard.2021.01.062. Epub 
      2021 Feb 3.