PMID- 33549458
OWN - NLM
STAT- MEDLINE
DCOM- 20210317
LR  - 20210317
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 31
IP  - 3
DP  - 2021 Mar 10
TI  - Protein intake is not associated with functional biomarkers of physical frailty: 
      A cross-sectional analysis of community-dwelling older adults with type 2 
      diabetes mellitus.
PG  - 827-833
LID - S0939-4753(20)30495-6 [pii]
LID - 10.1016/j.numecd.2020.11.018 [doi]
AB  - BACKGROUND AND AIM: Frailty has emerged as a third category of complication in 
      patients with type 2 diabetes mellitus (T2DM). It has been suggested that 
      adequate protein intake is an important dietary strategy for counteracting 
      frailty. Therefore, we explored the association between protein intake and 
      functional biomarkers of frailty in older adults with T2DM. METHODS AND RESULTS: 
      Frailty was operationalized as the presence of three of the following: 
      exhaustion, low muscle strength, low physical activity, slow gait speed, and 
      weight loss. Functional biomarkers included handgrip strength (HGS), chair 
      stands, the short physical performance battery and gait speed. Eighty-seven older 
      adults (71.2 +/- 8.2 years; 66.7% males) were included. A total of n = 6 (~7%) and 
      n = 32 (~37%) participants were identified as frail and pre-frail respectively. 
      No significant difference was observed for protein intake across staging of 
      frailty (pre-frail/frail: 1.3 +/- 0.4 g/kg BW; non-frail: 1.4 +/- 0.4 g/kg BW; 
      P = 0.320). A significant association was observed for total protein intake and 
      HGS (beta = 0.44; 95% CI: 0.23-1.8; P = 0.01). However, this was no longer 
      significant after adjusting for age, gender, physical activity, energy intake and 
      total appendicular lean muscle (beta = 0.03; 95% CI: -0.45-0.60; P = 0.78). Nil 
      other associations were observed between total protein intake and functional 
      biomarkers of frailty. CONCLUSION: Adequate protein intake was not associated 
      with functional biomarkers in older adults with T2DM. Future research should 
      focus on the efficacy of protein on attenuating functional decline in vulnerable 
      older adults with low protein intake.
CI  - Copyright (c) 2020 The Italian Diabetes Society, the Italian Society for the Study 
      of Atherosclerosis, the Italian Society of Human Nutrition and the Department of 
      Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. 
      All rights reserved.
FAU - Villani, Anthony
AU  - Villani A
AD  - School of Health and Behavioural Sciences, University of the Sunshine Coast, 
      Queensland Australia. Electronic address: avillani@usc.edu.au.
FAU - Barrett, Michelle
AU  - Barrett M
AD  - School of Health and Behavioural Sciences, University of the Sunshine Coast, 
      Queensland Australia.
FAU - McClure, Rebecca
AU  - McClure R
AD  - School of Health and Behavioural Sciences, University of the Sunshine Coast, 
      Queensland Australia.
FAU - Wright, Hattie
AU  - Wright H
AD  - School of Health and Behavioural Sciences, University of the Sunshine Coast, 
      Queensland Australia.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20201125
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Dietary Proteins)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology
MH  - Dietary Proteins/*administration & dosage
MH  - Exercise
MH  - Female
MH  - *Frail Elderly
MH  - Frailty/*diagnosis/epidemiology/physiopathology
MH  - Functional Status
MH  - Geriatric Assessment
MH  - Humans
MH  - *Independent Living
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength
MH  - Nutrition Assessment
MH  - Nutritional Status
MH  - Queensland/epidemiology
MH  - Recommended Dietary Allowances
MH  - Walking Speed
MH  - Weight Loss
OTO - NOTNLM
OT  - Frailty
OT  - Older adults
OT  - Physical performance
OT  - Protein
OT  - Type 2 diabetes
COIS- Declaration of competing interest The authors declare no conflict of interest.
EDAT- 2021/02/08 06:00
MHDA- 2021/03/18 06:00
CRDT- 2021/02/07 20:32
PHST- 2020/08/10 00:00 [received]
PHST- 2020/11/17 00:00 [revised]
PHST- 2020/11/18 00:00 [accepted]
PHST- 2021/02/08 06:00 [pubmed]
PHST- 2021/03/18 06:00 [medline]
PHST- 2021/02/07 20:32 [entrez]
AID - S0939-4753(20)30495-6 [pii]
AID - 10.1016/j.numecd.2020.11.018 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2021 Mar 10;31(3):827-833. doi: 
      10.1016/j.numecd.2020.11.018. Epub 2020 Nov 25.