PMID- 33549618
OWN - NLM
STAT- MEDLINE
DCOM- 20210421
LR  - 20240331
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 195
DP  - 2021 Apr
TI  - Associations between PM(2.5) metal components and QT interval length in the 
      Normative Aging Study.
PG  - 110827
LID - S0013-9351(21)00121-3 [pii]
LID - 10.1016/j.envres.2021.110827 [doi]
AB  - BACKGROUND: Several studies have found associations between increases in QT 
      interval length, a marker of cardiac electrical instability, and short-term fine 
      particulate matter (PM(2.5)) exposures. To our knowledge, this is the first study 
      to examine the association between specific PM(2.5) metal components and QT 
      interval length. METHODS: We measured heart-rate corrected QT interval (QTc) 
      duration among 630 participants in the Normative Aging Study (NAS) based in 
      Eastern Massachusetts between 2000 and 2011. We utilized time-varying linear 
      mixed-effects regressions with a random intercept for each participant to analyze 
      associations between QTc interval and moving averages (0-7 day moving averages) 
      of 24-h mean concentrations of PM(2.5) metal components (vanadium, nickel, 
      copper, zinc and lead) measured at the Harvard Supersite monitoring station. 
      Models were adjusted for daily PM(2.5) mass estimated at a 1 km x 1 km grid cell 
      from a previously validated prediction model and other covariates. Bayesian 
      kernel machine regression (BKMR) was utilized to assess the overall joint effect 
      of the PM(2.5) metal components. RESULTS: We found consistent results with higher 
      lead (Pb) associated with significant higher QTc intervals for both the 
      multi-pollutant and the two pollutant (PM(2.5) mass and a PM(2.5) component) 
      models across the moving averages. The greatest effect of lead on QTc interval 
      was detected for the 4-day moving average lead exposure. In the multi-pollutant 
      model, each 2.72 ng/m(3) increase in daily lead levels for a 4-day moving average 
      was associated with a 7.91 ms (95% CI: 3.63, 12.18) increase in QTc interval. In 
      the two-pollutant models with PM(2.5) mass and lead, each 2.72 ng/m(3) increase 
      in daily lead levels for a 4-day moving average was associated with an 8.50 ms 
      (95% CI: 4.59, 12.41) increase in QTc interval. We found that 4-day moving 
      average of copper has a negative association with QTc interval when compared to 
      the other PM(2.5) metal components. In the multi-pollutant model, each 
      1.81 ng/m(3) increase in daily copper levels for a 4-day moving average was 
      associated with an -3.89 ms (95% CI: -6.98, -0.79) increase in QTc interval. 
      Copper's essential function inside the human body could mediate its 
      cardiotoxicity on cardiac conductivity and explain why we found that copper in 
      comparison to the other metals was less harmful for QTc interval. CONCLUSIONS: 
      Exposure to metals contained in PM(2.5) are associated with acute changes in 
      ventricular repolarization as indicated by QT interval characteristics.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Peralta, Adjani A
AU  - Peralta AA
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States. Electronic address: aperalta@hsph.harvard.edu.
FAU - Schwartz, Joel
AU  - Schwartz J
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States; Department of Epidemiology, Harvard T.H. Chan School 
      of Public Health, Boston, MA, United States; Channing Division of Network 
      Medicine Department of Medicine, Brigham and Women's Hospital and Harvard Medical 
      School, Boston, MA, United States.
FAU - Gold, Diane R
AU  - Gold DR
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States; Channing Division of Network Medicine Department of 
      Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 
      United States.
FAU - Coull, Brent
AU  - Coull B
AD  - Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, 
      MA, United States.
FAU - Koutrakis, Petros
AU  - Koutrakis P
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA, United States.
LA  - eng
GR  - R835872/EPA/EPA/United States
GR  - T32 ES007069/ES/NIEHS NIH HHS/United States
GR  - T32 HL098048/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20210204
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
RN  - 2P299V784P (Lead)
SB  - IM
MH  - Aging
MH  - *Air Pollutants/analysis/toxicity
MH  - *Air Pollution/analysis
MH  - Bayes Theorem
MH  - Environmental Exposure/analysis
MH  - Humans
MH  - Lead
MH  - Massachusetts
MH  - Particulate Matter/analysis/toxicity
PMC - PMC7987821
MID - NIHMS1674360
OTO - NOTNLM
OT  - Air pollution
OT  - Fine particulate matter
OT  - Metals
OT  - QT interval
OT  - Ventricular repolarization
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/02/08 06:00
MHDA- 2021/04/22 06:00
PMCR- 2021/04/01
CRDT- 2021/02/07 20:33
PHST- 2020/09/21 00:00 [received]
PHST- 2021/01/15 00:00 [revised]
PHST- 2021/01/28 00:00 [accepted]
PHST- 2021/02/08 06:00 [pubmed]
PHST- 2021/04/22 06:00 [medline]
PHST- 2021/02/07 20:33 [entrez]
PHST- 2021/04/01 00:00 [pmc-release]
AID - S0013-9351(21)00121-3 [pii]
AID - 10.1016/j.envres.2021.110827 [doi]
PST - ppublish
SO  - Environ Res. 2021 Apr;195:110827. doi: 10.1016/j.envres.2021.110827. Epub 2021 
      Feb 4.