PMID- 33550042
OWN - NLM
STAT- MEDLINE
DCOM- 20210719
LR  - 20211108
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 137
DP  - 2021 May
TI  - The emerging roles of IDO2 in cancer and its potential as a therapeutic target.
PG  - 111295
LID - S0753-3322(21)00080-9 [pii]
LID - 10.1016/j.biopha.2021.111295 [doi]
AB  - During the past decades, tryptophan metabolism disorder was discovered to play a 
      vital and complex role in the development of cancer. Indoleamine 2,3-dioxygenase 
      2 (IDO2) is one of the initial and rate-limiting enzymes of the kynurenine 
      pathway of tryptophan catabolism. Increasing evidence indicates that IDO2 is 
      upregulated in some tumors and plays a role in the development of cancer. In 
      spite of the growing body of research, few reviews focused on the role of IDO2 in 
      cancer. Here, we review the emerging knowledge on the roles of IDO2 in cancer and 
      its potential as a therapeutic target. Firstly, the main biological features and 
      regulatory mechanisms are reviewed, after which we focus on the expression and 
      roles of IDO2 in cancer. Finally, we discuss the potential of IDO2 as a 
      therapeutic target for cancer treatment.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Li, Pengcheng
AU  - Li P
AD  - Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Xu, Weiqi
AU  - Xu W
AD  - Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Liu, Furong
AU  - Liu F
AD  - Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Zhu, He
AU  - Zhu H
AD  - Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Zhang, Lu
AU  - Zhang L
AD  - Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Ding, Zeyang
AU  - Ding Z
AD  - Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China. Electronic address: 
      zyding@tjh.tjmu.edu.cn.
FAU - Liang, Huifang
AU  - Liang H
AD  - Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China. Electronic address: 
      lianghuifang1997@126.com.
FAU - Song, Jia
AU  - Song J
AD  - Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China. Electronic address: 
      songjia19890813@163.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210204
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (IDO2 protein, human)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*therapeutic use
MH  - Enzyme Inhibitors/*therapeutic use
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/*antagonists & 
      inhibitors/genetics/metabolism
MH  - Molecular Targeted Therapy
MH  - Neoplasms/*drug therapy/enzymology/genetics/pathology
MH  - Signal Transduction
OTO - NOTNLM
OT  - 2,3-dioxygenase 2/IDO2
OT  - Cancer immunotherapy
OT  - Indoleamine
OT  - Kynurenine pathway
OT  - Therapeutic target
OT  - Tryptophan metabolism
EDAT- 2021/02/08 06:00
MHDA- 2021/07/20 06:00
CRDT- 2021/02/07 20:40
PHST- 2020/10/11 00:00 [received]
PHST- 2021/01/10 00:00 [revised]
PHST- 2021/01/18 00:00 [accepted]
PHST- 2021/02/08 06:00 [pubmed]
PHST- 2021/07/20 06:00 [medline]
PHST- 2021/02/07 20:40 [entrez]
AID - S0753-3322(21)00080-9 [pii]
AID - 10.1016/j.biopha.2021.111295 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2021 May;137:111295. doi: 10.1016/j.biopha.2021.111295. Epub 
      2021 Feb 4.