PMID- 33550533
OWN - NLM
STAT- MEDLINE
DCOM- 20210303
LR  - 20210303
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 113
IP  - 3
DP  - 2021 Mar
TI  - Diagnosis and treatment of disseminated intravascular coagulation in COVID-19 
      patients: a scoping review.
PG  - 320-329
LID - 10.1007/s12185-021-03084-z [doi]
AB  - BACKGROUND: Disseminated intravascular coagulation (DIC) is noted in severe cases 
      of coronavirus disease 2019 (COVID-19). Recently, a number of studies evaluating 
      the diagnosis and treatment of DIC in COVID-19 patients have been reported. 
      OBJECTIVE: The aim of this study is to identify existing gaps where further 
      research is needed on the diagnosis and treatment of DIC complicated by COVID-19. 
      METHODS: We used the PRISMA Extension for Scoping Reviews. MEDLINE, CENTRAL, 
      WHO-ICTRP, ClinicalTrial.gov and PROSPERO were searched from their inception to 6 
      October 2020. RESULTS: Seven studies were selected; five were already published 
      and two are ongoing. DIC was diagnosed using the International Society on 
      Thrombosis and Hemostasis (ISTH) DIC score (n = 4) and the sepsis-induced 
      coagulopathy (SIC) DIC score (n = 5). Seven studies examined the effectiveness of 
      low molecular weight heparin (LMWH); of these, four studies used a prophylactic 
      dose and five used a therapeutic dose of LMWH. A prophylactic dose of 
      unfractionated heparin (UFH) was investigated in two studies. CONCLUSION: Studies 
      on DIC diagnostic criteria and anticoagulants were limited to the ISTH or SIC 
      scores and heparinoids, particularly LMWH. Further studies are needed to compare 
      these with other available DIC scoring systems and anticoagulants.
FAU - Mori, Hirotaka
AU  - Mori H
AD  - Department of Hematology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 
      960-1295, Japan.
FAU - Ohkawara, Hiroshi
AU  - Ohkawara H
AD  - Department of Hematology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 
      960-1295, Japan.
FAU - Togawa, Ryuichi
AU  - Togawa R
AD  - Department of Respiratory Medicine, Fukushima Medical University, Fukushima, 
      960-1295, Japan.
FAU - Rikimaru, Mami
AU  - Rikimaru M
AD  - Department of Respiratory Medicine, Fukushima Medical University, Fukushima, 
      960-1295, Japan.
FAU - Shibata, Yoko
AU  - Shibata Y
AD  - Department of Respiratory Medicine, Fukushima Medical University, Fukushima, 
      960-1295, Japan.
FAU - Ikezoe, Takayuki
AU  - Ikezoe T
AUID- ORCID: 0000-0002-7858-278X
AD  - Department of Hematology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 
      960-1295, Japan. ikezoet@fmu.ac.jp.
LA  - eng
GR  - KAKENHI (18H02844)/KAKENHI/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20210207
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Anticoagulants/administration & dosage/adverse effects/therapeutic use
MH  - Blood Coagulation
MH  - Blood Coagulation Tests
MH  - COVID-19/*complications/*virology
MH  - Disease Management
MH  - Disease Susceptibility
MH  - Disseminated Intravascular Coagulation/blood/*diagnosis/*etiology/*therapy
MH  - Humans
MH  - Prognosis
MH  - *SARS-CoV-2
MH  - Treatment Outcome
PMC - PMC7868079
OTO - NOTNLM
OT  - Anticoagulants
OT  - COVID-19
OT  - Coagulopathy
OT  - Disseminated intravascular coagulation
OT  - Scoping review
COIS- All of the authors declare that they have no conflicts of interests.
EDAT- 2021/02/08 06:00
MHDA- 2021/03/04 06:00
PMCR- 2021/02/07
CRDT- 2021/02/07 20:53
PHST- 2020/09/04 00:00 [received]
PHST- 2021/01/13 00:00 [accepted]
PHST- 2021/01/12 00:00 [revised]
PHST- 2021/02/08 06:00 [pubmed]
PHST- 2021/03/04 06:00 [medline]
PHST- 2021/02/07 20:53 [entrez]
PHST- 2021/02/07 00:00 [pmc-release]
AID - 10.1007/s12185-021-03084-z [pii]
AID - 3084 [pii]
AID - 10.1007/s12185-021-03084-z [doi]
PST - ppublish
SO  - Int J Hematol. 2021 Mar;113(3):320-329. doi: 10.1007/s12185-021-03084-z. Epub 
      2021 Feb 7.