PMID- 33550747
OWN - NLM
STAT- MEDLINE
DCOM- 20210209
LR  - 20210209
IS  - 1561-9125 (Print)
IS  - 1561-9125 (Linking)
VI  - 33
IP  - 5
DP  - 2020
TI  - [The dynamics of the structural organization of the corpus callosum from young to 
      old age.].
PG  - 916-920
AB  - The work is based on the results of histological and immunohistochemical studies 
      performed on the sectional material of 104 human corpses (59 men and 45 women) of 
      young and old age. A comparative analysis of the morphological characteristics of 
      the corpus callosum tissues using hematoxylin and eosin staining, the Nissl 
      method (by Snesarev), by Van Gieson, by Spielmeyer, by Foot. An 
      immunohistochemical study of the samples used a panel of antibodies to glial 
      fibrillar acid protein (GFAP), the S-100 protein. It was found that by senile 
      age, the tissue of the corpus callosum is characterized by the accumulation of 
      glial macrophages. With age, there is a proliferation of GFAP-immunopositive 
      astroglia. There is no dynamics of S-100 protein expression with age. Thus, the 
      revealed regularity of age-related variability of the cytoarchitectonics of the 
      corpus callosum is of interest in diagnostic and therapeutic work, and its 
      morphological picture in old age can serve as an equivalent of the anatomical 
      norm.
FAU - Balandin, A A
AU  - Balandin AA
AD  - E.A.Vagner Perm State Medical University, 26 Petropavlovskaya str., Perm 414099, 
      Russian Federation, e mail: balandina_ia@mail.ru.
FAU - Zheleznov, L M
AU  - Zheleznov LM
AD  - Kirov State Medical University, 112 Karla Marksa str., Kirov 610027, Russian 
      Federation.
FAU - Balandina, I A
AU  - Balandina IA
AD  - E.A.Vagner Perm State Medical University, 26 Petropavlovskaya str., Perm 414099, 
      Russian Federation, e mail: balandina_ia@mail.ru.
FAU - Balandin, V A
AU  - Balandin VA
AD  - E.A.Vagner Perm State Medical University, 26 Petropavlovskaya str., Perm 414099, 
      Russian Federation, e mail: balandina_ia@mail.ru.
FAU - Borodulin, D V
AU  - Borodulin DV
AD  - E.A.Vagner Perm State Medical University, 26 Petropavlovskaya str., Perm 414099, 
      Russian Federation, e mail: balandina_ia@mail.ru.
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Adv Gerontol
JT  - Advances in gerontology = Uspekhi gerontologii
JID - 100971443
RN  - 0 (Glial Fibrillary Acidic Protein)
SB  - IM
MH  - *Aging
MH  - Astrocytes/metabolism
MH  - *Corpus Callosum/metabolism
MH  - Female
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Humans
MH  - Male
MH  - Neuroglia/metabolism
OTO - NOTNLM
OT  - astroglia
OT  - corpus callosum
OT  - immunohistochemistry
OT  - men
OT  - microglia
OT  - senile age
OT  - women
OT  - young age
EDAT- 2021/02/08 06:00
MHDA- 2021/02/10 06:00
CRDT- 2021/02/07 20:55
PHST- 2021/02/07 20:55 [entrez]
PHST- 2021/02/08 06:00 [pubmed]
PHST- 2021/02/10 06:00 [medline]
PST - ppublish
SO  - Adv Gerontol. 2020;33(5):916-920.