PMID- 33553356
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231110
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 9
IP  - 1
DP  - 2021 Jan
TI  - Temporal dynamic changes of intrinsic brain activity in Alzheimer's disease and 
      mild cognitive impairment patients: a resting-state functional magnetic resonance 
      imaging study.
PG  - 63
LID - 10.21037/atm-20-7214 [doi]
LID - 63
AB  - BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disease 
      characterized by memory impairment. Previous studies have largely focused on 
      alterations of static brain activity occurring in patients with AD. Few studies 
      to date have explored the characteristics of dynamic brain activity in cognitive 
      impairment, and their predictive ability in AD patients. METHODS: One hundred and 
      eleven AD patients, 29 MCI patients, and 73 healthy controls (HC) were recruited. 
      The dynamic amplitude of low-frequency fluctuation (dALFF) and the dynamic 
      fraction amplitude of low-frequency fluctuation (dfALFF) were used to assess the 
      temporal variability of local brain activity in patients with AD or mild 
      cognitive impairment (MCI). Pearson's correlation coefficients were calculated 
      between the metrics and subjects' behavioral scores. RESULTS: The results of 
      analysis of variance indicated that the AD, MCI, and HC groups showed significant 
      variability of dALFF in the cerebellar posterior and middle temporal lobes. In AD 
      patients, these brain regions had high dALFF variability. Significant dfALFF 
      variability was found between the three groups in the left calcarine cortex and 
      white matter. The AD group showed lower dfALFF than the MCI group in the left 
      calcarine cortex. CONCLUSIONS: Compared to HC, AD patients were found to have 
      increased dALFF variability in the cerebellar posterior and temporal lobes. This 
      abnormal pattern may diminish the capacity of the cerebellum and temporal lobes 
      to participate in the cerebrocerebellar circuits and default mode network (DMN), 
      which regulate cognition and emotion in AD. The findings above indicate that the 
      analysis of dALFF and dfALFF based on functional magnetic resonance imaging data 
      may give a new insight into the neurophysiological mechanisms of AD.
CI  - 2021 Annals of Translational Medicine. All rights reserved.
FAU - Li, Ting
AU  - Li T
AD  - Zhejiang Provincial People's Hospital, Qingdao University, Qingdao, China.
FAU - Liao, Zhengluan
AU  - Liao Z
AD  - Department of Psychiatry, Zhejiang Provincial People's Hospital, Hangzhou, China.
FAU - Mao, Yanping
AU  - Mao Y
AD  - Department of Psychological Medicine, Cancer Hospital of the University of 
      Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, China.
FAU - Hu, Jiaojiao
AU  - Hu J
AD  - Department of Psychological Medicine, Cancer Hospital of the University of 
      Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, China.
FAU - Le, Dansheng
AU  - Le D
AD  - The Second Clinical Medical College, Zhejiang Chinese Medical University, 
      Hangzhou, China.
FAU - Pei, Yangliu
AU  - Pei Y
AD  - Graduate faculty, Bengbu Medical College, Bengbu, China.
FAU - Sun, Wangdi
AU  - Sun W
AD  - The Second Clinical Medical College, Zhejiang Chinese Medical University, 
      Hangzhou, China.
FAU - Lin, Jixin
AU  - Lin J
AD  - Department of Internal Medicine, Shengsi County People's Hospital, Zhoushan, 
      China.
FAU - Qiu, Yaju
AU  - Qiu Y
AD  - Department of Psychiatry, Zhejiang Provincial People's Hospital, Hangzhou, China.
FAU - Zhu, Junpeng
AU  - Zhu J
AD  - Department of Psychiatry, Zhejiang Provincial People's Hospital, Hangzhou, China.
FAU - Chen, Yan
AU  - Chen Y
AD  - Department of Psychiatry, Zhejiang Provincial People's Hospital, Hangzhou, China.
FAU - Qi, Chang
AU  - Qi C
AD  - Department of Psychiatry, Zhejiang Provincial People's Hospital, Hangzhou, China.
FAU - Ye, Xiangming
AU  - Ye X
AD  - Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, 
      Hangzhou, China.
FAU - Su, Heng
AU  - Su H
AD  - Department of Psychiatry, Zhejiang Provincial People's Hospital, Hangzhou, China.
FAU - Yu, Enyan
AU  - Yu E
AD  - Department of Psychological Medicine, Cancer Hospital of the University of 
      Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
CIN - Ann Transl Med. 2021 Jun;9(12):1031. PMID: 34277831
PMC - PMC7859807
OTO - NOTNLM
OT  - Alzheimer's disease (AD)
OT  - dynamic fraction amplitude of low-frequency fluctuation (dfALFF)
OT  - mild cognitive impairment (MCI)
OT  - resting-state functional magnetic resonance imaging (rs-fMRI)
OT  - the dynamic amplitude of low-frequency fluctuation (dALFF)
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/atm-20-7214). The authors have no 
      conflicts of interest to declare.
EDAT- 2021/02/09 06:00
MHDA- 2021/02/09 06:01
PMCR- 2021/01/01
CRDT- 2021/02/08 05:48
PHST- 2021/02/08 05:48 [entrez]
PHST- 2021/02/09 06:00 [pubmed]
PHST- 2021/02/09 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - atm-09-01-63 [pii]
AID - 10.21037/atm-20-7214 [doi]
PST - ppublish
SO  - Ann Transl Med. 2021 Jan;9(1):63. doi: 10.21037/atm-20-7214.