PMID- 33553412
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210210
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 9
IP  - 3
DP  - 2021 Jan 26
TI  - Systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated 
      vasculitis overlap syndrome in a 77-year-old man: A case report.
PG  - 707-713
LID - 10.12998/wjcc.v9.i3.707 [doi]
AB  - BACKGROUND: Systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV) are classically thought to cause renal 
      impairment and small vessel vasculitis with different pathophysiologies. Their 
      overlap constitutes a rare rheumatologic disease. To date, only dozens of such 
      cases with biopsy-proven glomerulonephritis have been reported worldwide 
      typically in women of childbearing age. Here, we present a unique clinical case 
      due to its rarity and individualized treatment of a Chinese man in his eighth 
      decade of life. CASE SUMMARY: A 77-year-old man was admitted to several hospitals 
      for shortness of breath and received nonspecific treatments over the past 3 
      years. As his symptoms were not completely relieved, he visited our hospital for 
      further treatment. Laboratory examinations revealed kidney dysfunction, severe 
      anaemia, hypocom-plementemia, glomerular proteinuria, and microscopic haematuria. 
      Antinuclear antibodies, as well as anti-dsDNA antibodies, were positive. Computed 
      tomography of the chest showed right pleural effusion. Renal biopsy was 
      performed, and histology suggested crescentic glomerulonephritis, pauci-immune 
      type. After treatment with plasmapheresis, glucocorticoid, and cyclo-phosphamide, 
      the disease was in remission, and the patient remained in a stable condition for 
      over 3 years post-hospital discharge. CONCLUSION: Due to its complexity and 
      rarity, SLE and AAV overlap syndrome is easily misdiagnosed. An accurate 
      diagnosis and treatment at the earliest stage may significantly improve the 
      condition and reduce irreversible organ injury.
CI  - (c)The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Xu, Zi-Gan
AU  - Xu ZG
AD  - Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen 
      518110, Guangdong Province, China.
FAU - Li, Wei-Long
AU  - Li WL
AD  - Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen 
      518110, Guangdong Province, China.
FAU - Wang, Xi
AU  - Wang X
AD  - Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen 
      518110, Guangdong Province, China.
FAU - Zhang, Shu-Yuan
AU  - Zhang SY
AD  - Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen 
      518110, Guangdong Province, China.
FAU - Zhang, Ying-Wei
AU  - Zhang YW
AD  - Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen 
      518110, Guangdong Province, China.
FAU - Wei, Xing
AU  - Wei X
AD  - Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen 
      518110, Guangdong Province, China.
FAU - Li, Chun-Di
AU  - Li CD
AD  - Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen 
      518110, Guangdong Province, China.
FAU - Zeng, Ping
AU  - Zeng P
AD  - Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen 
      518110, Guangdong Province, China.
FAU - Luan, Shao-Dong
AU  - Luan SD
AD  - Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen 
      518110, Guangdong Province, China. szkidney3@163.com.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC7829731
OTO - NOTNLM
OT  - Antineutrophil cytoplasmic antibody-associated vasculitis
OT  - Case report
OT  - Elderly male
OT  - Overlap syndrome
OT  - Renal insufficiency
OT  - Systemic lupus erythematosus
COIS- Conflict-of-interest statement: The authors declare that they have no conflict of 
      interest to disclose.
EDAT- 2021/02/09 06:00
MHDA- 2021/02/09 06:01
PMCR- 2021/01/26
CRDT- 2021/02/08 05:48
PHST- 2020/09/15 00:00 [received]
PHST- 2020/11/23 00:00 [revised]
PHST- 2020/11/29 00:00 [accepted]
PHST- 2021/02/08 05:48 [entrez]
PHST- 2021/02/09 06:00 [pubmed]
PHST- 2021/02/09 06:01 [medline]
PHST- 2021/01/26 00:00 [pmc-release]
AID - 10.12998/wjcc.v9.i3.707 [doi]
PST - ppublish
SO  - World J Clin Cases. 2021 Jan 26;9(3):707-713. doi: 10.12998/wjcc.v9.i3.707.