PMID- 33554428
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20211224
IS  - 1751-7176 (Electronic)
IS  - 1524-6175 (Print)
IS  - 1524-6175 (Linking)
VI  - 23
IP  - 6
DP  - 2021 Jun
TI  - Hypertension-mediated organ damage regression associates with blood pressure 
      variability improvement three years after successful treatment initiation in 
      essential hypertension.
PG  - 1150-1158
LID - 10.1111/jch.14209 [doi]
AB  - Blood pressure variability (BPV) has been associated with the development, 
      progression, and severity of cardiovascular (CV) organ damage and an increased 
      risk of CV morbidity and mortality. We aimed to explore any association between 
      short-term BPV reduction and hypertension-mediated organ damage (HMOD) regression 
      in hypertensive patients 3-year post-treatment initiation regarding BP control. 
      24-h ambulatory blood pressure monitoring (24 h ABPM) was performed at baseline 
      in 180 newly diagnosed and never-treated hypertensive patients. We measured 24 h 
      average systolic (24 h SBP) and diastolic BP (24 h DBP) as well as 24 h systolic 
      (sBPV) and diastolic BPV (dBPV). Patients were initially evaluated and 3 years 
      later regarding arterial stiffness (PWV), left ventricular hypertrophy (LVMI), 
      carotid intima-media thickness (cIMT), 24 h microalbumin levels (MAU), and 
      coronary flow reserve (CFR). Successful BP treatment was defined as 24 h 
      SBP/DBP < 130/80 mm Hg based on 2nd ABPM and subsequently, patients were 
      characterized as controlled (n = 119, age = 53 +/- 11 years) or non-controlled 
      (n = 61, age = 47 +/- 11 years) regarding their BP levels. In the whole population 
      and the controlled group, 24 h SBP/DBP, sBPV/dBPV, LVMI, and IMT were decreased. 
      Additionally, LVMI improvement was related with both sBPV (p < .001) and dBPV 
      reduction (r = .18, p = .02 and r = .20, p = .03, respectively). In 
      non-controlled hypertensives, PWV was increased. In multiple linear regression 
      analysis, sBPV and dBPV reduction predicted LVMI improvement in total population 
      and controlled group independently of initial office SBP, mean BP, and 24 h-SBP 
      levels. In middle-aged hypertensive patients, a 3-year antihypertensive treatment 
      within normal BP limits, confirmed by 24-h ABPM, leads to CV risk reduction 
      associated with sBPV and dBPV improvement.
CI  - (c) 2021 The Authors. The Journal of Clinical Hypertension published by Wiley 
      Periodicals LLC.
FAU - Triantafyllidi, Helen
AU  - Triantafyllidi H
AUID- ORCID: 0000-0001-6801-1214
AD  - 2nd Department of Cardiology Medical School, University of Athens, ATTIKON 
      Hospital, Athens, Greece.
FAU - Benas, Dimitrios
AU  - Benas D
AD  - 2nd Department of Cardiology Medical School, University of Athens, ATTIKON 
      Hospital, Athens, Greece.
FAU - Schoinas, Antonios
AU  - Schoinas A
AD  - 2nd Department of Cardiology Medical School, University of Athens, ATTIKON 
      Hospital, Athens, Greece.
FAU - Birmpa, Dionyssia
AU  - Birmpa D
AD  - 2nd Department of Cardiology Medical School, University of Athens, ATTIKON 
      Hospital, Athens, Greece.
FAU - Trivilou, Paraskevi
AU  - Trivilou P
AD  - 2nd Department of Cardiology Medical School, University of Athens, ATTIKON 
      Hospital, Athens, Greece.
FAU - Varytimiadi, Efthimia
AU  - Varytimiadi E
AD  - 2nd Department of Cardiology Medical School, University of Athens, ATTIKON 
      Hospital, Athens, Greece.
FAU - Voutsinos, Dimitrios
AU  - Voutsinos D
AD  - 2nd Department of Cardiology Medical School, University of Athens, ATTIKON 
      Hospital, Athens, Greece.
FAU - Ikonomidis, Ignatios
AU  - Ikonomidis I
AD  - 2nd Department of Cardiology Medical School, University of Athens, ATTIKON 
      Hospital, Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20210207
PL  - United States
TA  - J Clin Hypertens (Greenwich)
JT  - Journal of clinical hypertension (Greenwich, Conn.)
JID - 100888554
SB  - IM
MH  - Adult
MH  - Blood Pressure
MH  - *Blood Pressure Monitoring, Ambulatory
MH  - Carotid Intima-Media Thickness
MH  - Essential Hypertension
MH  - Humans
MH  - *Hypertension/diagnosis/drug therapy
MH  - Middle Aged
PMC - PMC8678708
OTO - NOTNLM
OT  - 24 h ambulatory blood pressure measurement
OT  - arterial hypertension
OT  - blood pressure variability
OT  - hypertension-mediated organ damage
EDAT- 2021/02/09 06:00
MHDA- 2021/06/29 06:00
PMCR- 2021/02/07
CRDT- 2021/02/08 06:02
PHST- 2020/12/13 00:00 [revised]
PHST- 2020/10/21 00:00 [received]
PHST- 2020/12/19 00:00 [accepted]
PHST- 2021/02/09 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/02/08 06:02 [entrez]
PHST- 2021/02/07 00:00 [pmc-release]
AID - JCH14209 [pii]
AID - 10.1111/jch.14209 [doi]
PST - ppublish
SO  - J Clin Hypertens (Greenwich). 2021 Jun;23(6):1150-1158. doi: 10.1111/jch.14209. 
      Epub 2021 Feb 7.