PMID- 33555260 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210903 IS - 2561-1011 (Electronic) IS - 2561-1011 (Linking) VI - 5 IP - 1 DP - 2021 Feb 8 TI - Heart Rate Measurements in Patients with Obstructive Sleep Apnea and Atrial Fibrillation: Prospective Pilot Study Assessing Apple Watch's Agreement With Telemetry Data. PG - e18050 LID - 10.2196/18050 [doi] LID - e18050 AB - BACKGROUND: Patients with obstructive sleep apnea (OSA) are at a higher risk for atrial fibrillation (AF). Consumer wearable heart rate (HR) sensors may be a means for passive HR monitoring in patients with AF. OBJECTIVE: The aim of this study was to assess the Apple Watch's agreement with telemetry in measuring HR in patients with OSA in AF. METHODS: Patients with OSA in AF were prospectively recruited prior to cardioversion/ablation procedures. HR was sampled every 10 seconds for 60 seconds using telemetry and an Apple Watch concomitantly. Agreement of Apple Watch with telemetry, which is the current gold-standard device for measuring HR, was assessed using mixed effects limits agreement and Lin's concordance correlation coefficient. RESULTS: A total of 20 patients (mean 66 [SD 6.5] years, 85% [n=17] male) participated in this study, yielding 134 HR observations per device. Modified Bland-Altman plot revealed that the variability of the paired difference of the Apple Watch compared with telemetry increased as the magnitude of HR measurements increased. The Apple Watch produced regression-based 95% limits of agreement of 27.8 - 0.3 x average HR - 15.0 to 27.8 - 0.3 x average HR + 15.0 beats per minute (bpm) with a mean bias of 27.8 - 0.33 x average HR bpm. Lin's concordance correlation coefficient was 0.88 (95% CI 0.85-0.91), suggesting acceptable agreement between the Apple Watch and telemetry. CONCLUSIONS: In patients with OSA in AF, the Apple Watch provided acceptable agreement with HR measurements by telemetry. Further studies with larger sample populations and wider range of HR are needed to confirm these findings. CI - (c)Pauline Huynh, Rongzi Shan, Ngozi Osuji, Jie Ding, Nino Isakadze, Francoise A Marvel, Garima Sharma, Seth S Martin. Originally published in JMIR Cardio (http://cardio.jmir.org), 08.02.2021. FAU - Huynh, Pauline AU - Huynh P AUID- ORCID: 0000-0001-5878-1442 AD - School of Medicine, Johns Hopkins University, Baltimore, MD, United States. FAU - Shan, Rongzi AU - Shan R AUID- ORCID: 0000-0002-0445-5702 AD - Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States. AD - David Geffen School of Medicine, University of California, Los Angeles, CA, United States. FAU - Osuji, Ngozi AU - Osuji N AUID- ORCID: 0000-0002-4772-8213 AD - Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States. FAU - Ding, Jie AU - Ding J AUID- ORCID: 0000-0002-7071-7424 AD - Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States. FAU - Isakadze, Nino AU - Isakadze N AUID- ORCID: 0000-0002-5396-2110 AD - School of Medicine, Johns Hopkins University, Baltimore, MD, United States. AD - Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States. FAU - Marvel, Francoise A AU - Marvel FA AUID- ORCID: 0000-0002-6422-1772 AD - School of Medicine, Johns Hopkins University, Baltimore, MD, United States. AD - Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States. FAU - Sharma, Garima AU - Sharma G AUID- ORCID: 0000-0001-7254-2077 AD - School of Medicine, Johns Hopkins University, Baltimore, MD, United States. AD - Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States. FAU - Martin, Seth S AU - Martin SS AUID- ORCID: 0000-0002-7021-7622 AD - School of Medicine, Johns Hopkins University, Baltimore, MD, United States. AD - Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States. LA - eng PT - Journal Article DEP - 20210208 PL - Canada TA - JMIR Cardio JT - JMIR cardio JID - 101718325 PMC - PMC8411424 OTO - NOTNLM OT - atrial fibrillation OT - digital health OT - mHealth OT - obstructive sleep apnea OT - wearables COIS- Conflicts of Interest: FM and SM are founders of and hold equity in Corrie Health, which intends to further develop the digital platform. This arrangement has been reviewed and approved by the Johns Hopkins University in accordance with its conflict of interest policies. Outside of this work, they have received material support from Apple and iHealth and funding from the Maryland Innovation Initiative, Wallace H. Coulter Translational Research Partnership, Louis B. Thalheimer Fund, the Johns Hopkins Individualized Health Initiative, and American Heart Association. SM also reports additional research support from the Aetna Foundation, the American Heart Association, the David and June Trone Family Foundation, Google, the National Institutes of Health, Nokia, and the PJ Schafer Memorial Fund. SM reports personal fees for serving on scientific advisory boards for Akcea Therapeutics, Amgen, Esperion, Novo Nordisk, Quest Diagnostics, Regeneron, and Sanofi. SM is a coinventor on a pending patent filed by The Johns Hopkins University for a system of low-density lipoprotein cholesterol estimation. Other authors have nothing to declare. EDAT- 2021/02/09 06:00 MHDA- 2021/02/09 06:01 PMCR- 2021/02/08 CRDT- 2021/02/08 12:09 PHST- 2020/01/30 00:00 [received] PHST- 2020/12/15 00:00 [accepted] PHST- 2020/06/30 00:00 [revised] PHST- 2021/02/08 12:09 [entrez] PHST- 2021/02/09 06:00 [pubmed] PHST- 2021/02/09 06:01 [medline] PHST- 2021/02/08 00:00 [pmc-release] AID - v5i1e18050 [pii] AID - 10.2196/18050 [doi] PST - epublish SO - JMIR Cardio. 2021 Feb 8;5(1):e18050. doi: 10.2196/18050.