PMID- 33555661
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 99
IP  - 7
DP  - 2021 Nov
TI  - Longitudinal changes in the ganglion cell-inner plexiform layer thickness of 
      age-related macular degeneration.
PG  - e1056-e1062
LID - 10.1111/aos.14784 [doi]
AB  - PURPOSE: To determine longitudinal changes of the ganglion cell-inner plexiform 
      layer (GC-IPL) thickness in patients with non-exudative age-related macular 
      degeneration (AMD) without other ophthalmic disease. METHODS: Thirty-three eyes 
      of 33 patients with early and intermediate non-exudative AMD (non-exudative AMD 
      group) and 33 normal control eyes were followed for 2 years, and GC-IPL thickness 
      was measured by spectral domain optical coherence tomography at 1-year intervals. 
      The mean rate of GC-IPL reduction was estimated using a linear mixed model and 
      compared between two groups. RESULTS: The mean age of patients in the 
      non-exudative AMD group and control groups were 68.82 +/- 6.81 years and 
      67.73 +/- 5.87 years, respectively (p = 0.488). The mean GC-IPL thickness at the 
      first visit was 76.61 +/- 16.33 mum in the non-exudative AMD and 81.76 +/- 3.69 mum in 
      control group (p = 0.387), and these values significantly decreased over time, 
      with an average reduction rate of average GC-IPL -0.86 mum/year in the 
      non-exudative AMD group and -0.32 mum/year in the control group. The difference 
      between two groups was statistically significant (p < 0.001), and there was also 
      a significant interaction between group and duration in linear mixed models in 
      mean GC-IPL thickness (p = 0.001). CONCLUSIONS: The reduction rate of the GC-IPL 
      thickness was greater in non-exudative AMD eyes, even at relatively early stages 
      of the disease. Physicians should maintain awareness of the presence of 
      non-exudative AMD in various cases of ophthalmic diseases where GC-IPL thickness 
      evaluation is necessary.
CI  - (c) 2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Kim, Ju Mi
AU  - Kim JM
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Korea.
FAU - Lee, Min-Woo
AU  - Lee MW
AD  - Department of Ophthalmology, Konyang University college of medicine, Daejeon, 
      Korea.
FAU - Lim, Hyung Bin
AU  - Lim HB
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Korea.
FAU - Won, Yeo Kyoung
AU  - Won YK
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Korea.
FAU - Shin, Yong-Il
AU  - Shin YI
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Korea.
FAU - Lee, Woo-Hyuck
AU  - Lee WH
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Korea.
FAU - Kim, Jung-Yeul
AU  - Kim JY
AUID- ORCID: 0000-0003-3679-1310
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Korea.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210208
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Aged
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Macular Degeneration/*diagnosis
MH  - Male
MH  - Nerve Fibers/pathology
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/*methods
OTO - NOTNLM
OT  - GC-IPL
OT  - non-exudative AMD
OT  - spectral domain optical coherence tomography
EDAT- 2021/02/09 06:00
MHDA- 2022/02/01 06:00
CRDT- 2021/02/08 12:15
PHST- 2020/11/22 00:00 [revised]
PHST- 2020/02/18 00:00 [received]
PHST- 2021/01/12 00:00 [accepted]
PHST- 2021/02/09 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/02/08 12:15 [entrez]
AID - 10.1111/aos.14784 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2021 Nov;99(7):e1056-e1062. doi: 10.1111/aos.14784. Epub 2021 
      Feb 8.