PMID- 33558526
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20230919
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Feb 8
TI  - Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and 
      transected anesthetized rats.
PG  - 3268
LID - 10.1038/s41598-021-81822-3 [doi]
LID - 3268
AB  - Spinal cord epidural stimulation (scES) mapping at L5-S1 was performed to 
      identify parameters for bladder and bowel inhibition and/or contraction. Using 
      spinally intact and chronic transected rats of both sexes in acute 
      urethane-anesthetized terminal preparations, scES was systematically applied 
      using a modified Specify 5-6-5 (Medtronic) electrode during bladder 
      filling/emptying cycles while recording bladder and colorectal pressures and 
      external urethral and anal sphincter electromyography activity. The results 
      indicate frequency-dependent effects on void volume, micturition, bowel 
      peristalsis, and sphincter activity just above visualized movement threshold 
      intensities that differed depending upon neurological intactness, with some 
      sex-dependent differences. Thereafter, a custom-designed miniature 15-electrode 
      array designed for greater selectivity was tested and exhibited the same 
      frequency-dependent urinary effects over a much smaller surface area without any 
      concurrent movements. Thus, select activation of autonomic nervous system 
      circuitries with scES is a promising neuromodulation approach for expedient 
      translation to individuals with SCI and potentially other neurologic disorders.
FAU - Hoey, Robert F
AU  - Hoey RF
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville 
      School of Medicine, MDR, 511 S. Floyd St., Room 111, Louisville, KY, 40202, USA.
FAU - Medina-Aguinaga, Daniel
AU  - Medina-Aguinaga D
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville 
      School of Medicine, MDR, 511 S. Floyd St., Room 111, Louisville, KY, 40202, USA.
FAU - Khalifa, Fahmi
AU  - Khalifa F
AD  - Bioengineering Department, University of Louisville J. B. Speed School of 
      Engineering, Louisville, KY, USA.
FAU - Ugiliweneza, Beatrice
AU  - Ugiliweneza B
AD  - Department of Neurological Surgery, University of Louisville School of Medicine, 
      Louisville, KY, USA.
FAU - Zdunowski, Sharon
AU  - Zdunowski S
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA.
FAU - Fell, Jason
AU  - Fell J
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville 
      School of Medicine, MDR, 511 S. Floyd St., Room 111, Louisville, KY, 40202, USA.
FAU - Naglah, Ahmed
AU  - Naglah A
AD  - Bioengineering Department, University of Louisville J. B. Speed School of 
      Engineering, Louisville, KY, USA.
FAU - El-Baz, Ayman S
AU  - El-Baz AS
AD  - Bioengineering Department, University of Louisville J. B. Speed School of 
      Engineering, Louisville, KY, USA.
FAU - Herrity, April N
AU  - Herrity AN
AD  - Department of Neurological Surgery, University of Louisville School of Medicine, 
      Louisville, KY, USA.
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA.
FAU - Harkema, Susan J
AU  - Harkema SJ
AD  - Department of Neurological Surgery, University of Louisville School of Medicine, 
      Louisville, KY, USA.
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA.
FAU - Hubscher, Charles H
AU  - Hubscher CH
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville 
      School of Medicine, MDR, 511 S. Floyd St., Room 111, Louisville, KY, 40202, USA. 
      chhubs01@louisville.edu.
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA. chhubs01@louisville.edu.
LA  - eng
GR  - OT2OD024898/NH/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20210208
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Anal Canal/*physiopathology
MH  - Animals
MH  - Colon/*physiopathology
MH  - Female
MH  - Male
MH  - *Muscle Contraction
MH  - *Peristalsis
MH  - Rats
MH  - Rats, Wistar
MH  - Spinal Cord Injuries/*physiopathology/therapy
MH  - *Spinal Cord Stimulation
MH  - Urethra/*physiopathology
MH  - Urinary Bladder/*physiopathology
PMC - PMC7870824
COIS- The authors declare no competing interests.
EDAT- 2021/02/10 06:00
MHDA- 2021/11/16 06:00
PMCR- 2021/02/08
CRDT- 2021/02/09 06:19
PHST- 2020/09/29 00:00 [received]
PHST- 2021/01/12 00:00 [accepted]
PHST- 2021/02/09 06:19 [entrez]
PHST- 2021/02/10 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/02/08 00:00 [pmc-release]
AID - 10.1038/s41598-021-81822-3 [pii]
AID - 81822 [pii]
AID - 10.1038/s41598-021-81822-3 [doi]
PST - epublish
SO  - Sci Rep. 2021 Feb 8;11(1):3268. doi: 10.1038/s41598-021-81822-3.