PMID- 33559083
OWN - NLM
STAT- MEDLINE
DCOM- 20220301
LR  - 20220301
IS  - 2520-8721 (Electronic)
IS  - 1109-3099 (Linking)
VI  - 20
IP  - 3
DP  - 2021 Sep
TI  - The relationship of mesencephalic astrocyte-derived neurotrophic factor with 
      hyperlipidemia in patients with or without type 2 diabetes mellitus.
PG  - 537-543
LID - 10.1007/s42000-021-00272-8 [doi]
AB  - PURPOSE: This study was conducted to determine the relationship between 
      mesencephalic astrocyte-derived neurotrophic factor (MANF) and lipid metabolism 
      with or without type 2 diabetes mellitus (T2DM). METHODS: Human serum samples 
      were collected from 58 normal controls (NC), 40 subjects with hyperlipidemia 
      (HLD) without T2DM, and 42 subjects with HLD and T2DM. Their MANF levels were 
      detected using an enzyme-linked immunosorbent assay (ELISA). Subgroup analysis 
      was performed in the group with HLD and T2DM based on fasting blood glucose 
      (FBG) > 8.22 vs. FBG </= 8.22. Furthermore, the relationship between MANF levels 
      and lipid indices was analyzed. RESULTS: Serum MANF levels were found to be 
      significantly higher in the HLD group, both with and without T2DM (5.62 
      (3.59-7.11) and 4.21 (2.87-6.11)), both P < 0.001, than in the NC 
      (2.81(1.81-4.01). MANF levels were higher in those with FBG > 8.22 than that in 
      those with FBG </= 8.22. In addition, in the HLD without T2DM group, MANF levels 
      were negatively correlated with total cholesterol (TC), low-density lipoprotein 
      cholesterol (LDL-C), and age, while LDL-C and age were independently related to 
      MANF levels. The area under the curve (AUC) in the ROC analysis of MANF for the 
      diagnosis of HLD without T2DM and HLD with T2DM was 0.709 and 0.841, respectively 
      (P < 0.001). CONCLUSION: Serum MANF levels increased in the HLD with or without 
      T2DM groups and was associated with lipid and glucose metabolism. MANF may be a 
      useful marker for predicting the development of dyslipidemia in T2DM.
CI  - (c) 2021. Hellenic Endocrine Society.
FAU - Fu, Jili
AU  - Fu J
AD  - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of 
      Chongqing Medical University, 76, Linjiang Road, Yuzhong District, 400010, 
      Chongqing, China.
AD  - Daping Hospital, Army Medical University (Third Military Medical University), 
      Chongqing, China.
FAU - Malale, Kija
AU  - Malale K
AD  - Department of Gastroenterology, The Second Affiliated Hospital of Chongqing 
      Medical University, 76, Linjiang Road, Yuzhong District, 400010, Chongqing, 
      China.
AD  - Archbishop Anthony Mayala School of Nursing, Catholic University of Health and 
      Allied Sciences, Mwanza, Tanzania.
FAU - Luo, Xie
AU  - Luo X
AD  - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of 
      Chongqing Medical University, 76, Linjiang Road, Yuzhong District, 400010, 
      Chongqing, China.
FAU - Chen, Min
AU  - Chen M
AD  - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of 
      Chongqing Medical University, 76, Linjiang Road, Yuzhong District, 400010, 
      Chongqing, China.
FAU - Liu, Qicong
AU  - Liu Q
AD  - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of 
      Chongqing Medical University, 76, Linjiang Road, Yuzhong District, 400010, 
      Chongqing, China.
FAU - Cheng, Wei
AU  - Cheng W
AD  - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of 
      Chongqing Medical University, 76, Linjiang Road, Yuzhong District, 400010, 
      Chongqing, China. 83269230@qq.com.
FAU - Liu, Dongfang
AU  - Liu D
AUID- ORCID: 0000-0002-8801-2190
AD  - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of 
      Chongqing Medical University, 76, Linjiang Road, Yuzhong District, 400010, 
      Chongqing, China.
LA  - eng
GR  - 81370467/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20210208
PL  - Switzerland
TA  - Hormones (Athens)
JT  - Hormones (Athens, Greece)
JID - 101142469
RN  - 0 (Cholesterol, LDL)
RN  - 0 (MANF protein, human)
RN  - 0 (Nerve Growth Factors)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Age Factors
MH  - Cholesterol, LDL
MH  - *Diabetes Mellitus, Type 2
MH  - Glucose/metabolism
MH  - Humans
MH  - *Hyperlipidemias
MH  - *Lipid Metabolism
MH  - Nerve Growth Factors/*blood
OTO - NOTNLM
OT  - Hyperlipidemia
OT  - Mesencephalic astrocyte-derived neurotrophic factor
OT  - Type 2 diabetes mellitus
EDAT- 2021/02/10 06:00
MHDA- 2022/03/03 06:00
CRDT- 2021/02/09 06:37
PHST- 2020/07/30 00:00 [received]
PHST- 2021/01/17 00:00 [accepted]
PHST- 2021/02/10 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/02/09 06:37 [entrez]
AID - 10.1007/s42000-021-00272-8 [pii]
AID - 10.1007/s42000-021-00272-8 [doi]
PST - ppublish
SO  - Hormones (Athens). 2021 Sep;20(3):537-543. doi: 10.1007/s42000-021-00272-8. Epub 
      2021 Feb 8.